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Recombinant Human Transmembrane protein 98 (TMEM98)

  • 中文名稱:
    人TMEM98重組蛋白
  • 貨號:
    CSB-EP023901HU
  • 規(guī)格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    TMEM98
  • Uniprot No.:
  • 別名:
    TMEM98; UNQ536/PRO1079; Transmembrane protein 98; Protein TADA1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    E.coli
  • 分子量:
    26.2kDa
  • 表達區(qū)域:
    25-226aa
  • 氨基酸序列
    LVCRQRYCRPRDLLQRYDSKPIVDLIGAMETQSEPSELELDDVVITNPHIEAILENEDWIEDASGLMSHCIAILKICHTLTEKLVAMTMGSGAKMKTSASVSDIIVVAKRISPRVDDVVKSMYPPLDPKLLDARTTALLLSVSHLVLVTRNACHLTGGLDWIDQSLSAAEEHLEVLREAALASEPDKGLPGPEGFLQEQSAI
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1).
  • 基因功能參考文獻:
    1. siRNA-TMEM98 inhibited the invasion and migration of non-small cell lung cancer cells. PMID: 26884835
    2. Two novel TMEM98 mutations have been found in two pedigrees with autosomal dominant nanophthalmos. PMID: 26392740
    3. we identified a panel of novel common chemoresistance-associated genes and demonstrated that TMEM98 is a chemoresistance-conferring gene in hepatocellular carcinoma. PMID: 24608572
    4. A novel gene associated with nanophthalmos, TMEM98 most likely represents the cause of the disease. PMID: 24852644
  • 相關(guān)疾病:
    Nanophthalmos 4 (NNO4)
  • 亞細胞定位:
    Cell membrane; Single-pass type II membrane protein. Secreted. Secreted, extracellular exosome. Endoplasmic reticulum membrane; Single-pass type II membrane protein.
  • 蛋白家族:
    TMEM98 family
  • 組織特異性:
    Widely expressed with high expression in the ovary, pancreas and prostate. Expressed in the eye, particularly in corneal endothelium, iris, ciliary body, sclera, optic nerve, optic nerve head, and retina. Expressed by activated peripheral blood mononuclea
  • 數(shù)據(jù)庫鏈接:

    HGNC: 24529

    OMIM: 615949

    KEGG: hsa:26022

    STRING: 9606.ENSP00000378138

    UniGene: Hs.3447



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