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  4. Recombinant Human Translin-associated protein X (TSNAX)

Recombinant Human Translin-associated protein X (TSNAX)

  • 中文名稱：
    人TSNAX重組蛋白
  • 貨號：
    CSB-YP858718HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人TSNAX重組蛋白
  • 貨號：
    CSB-EP858718HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人TSNAX重組蛋白
  • 貨號：
    CSB-EP858718HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人TSNAX重組蛋白
  • 貨號：
    CSB-BP858718HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人TSNAX重組蛋白
  • 貨號：
    CSB-MP858718HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    TSNAX
  • Uniprot No.：
  • 別名：
    Translin associated factor X; Translin like protein; Translin-associated factor X; Translin-associated protein X; TSNAX; TSNAX_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-290
  • 氨基酸序列
    MSNKEGSGGF RKRKHDNFPH NQRREGKDVN SSSPVMLAFK SFQQELDARH DKYERLVKLS RDITVESKRT IFLLHRITSA PDMEDILTES EIKLDGVRQK IFQVAQELSG EDMHQFHRAI TTGLQEYVEA VSFQHFIKTR SLISMDEINK QLIFTTEDNG KENKTPSSDA QDKQFGTWRL RVTPVDYLLG VADLTGELMR MCINSVGNGD IDTPFEVSQF LRQVYDGFSF IGNTGPYEVS KKLYTLKQSL AKVENACYAL KVRGSEIPKH MLADVFSVKT EMIDQEEGIS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis.
  • 基因功能參考文獻：
    1. TSNAX protein is known to form a brain enriched complex with translin, that can bind single-stranded DNA and RNA through which it is involved in protein regulation. PMID: 25043320
    2. High chimeric TSNAX-DISC1 resulting from intergenic splicing is associated with endometrial carcinoma. PMID: 25239642
    3. LIS1 and TSNAX genes are not associated with susceptibility to bipolar I disorder in Chinese Han population. PMID: 24928020
    4. Data show a novel role of phospholipase Cbeta1 (PLCbeta1) in gene regulation through translin-associated factor X (TRAX) association. PMID: 22889834
    5. Our results provide further evidence for sex-dependent effects of the TSNAX/DISC1 locus in the aetiology of schizophrenia and bipolar affective disorder PMID: 22673686
    6. TRAX binds to ssDNA and two regions in TRAX, designated TRAXB2 and TRAXB3, mediate nucleic acid binding activity of the trax-translin heteromeric complex. PMID: 22427937
    7. The results of this suggested an association between the TSNAX-DISC1 region and both forms of affective disorders. PMID: 19255581
    8. Results suggest that rs766288 in translin-associated factor X gene may play a role in the pathophysiology of female major depressive disorder in the Japanese population. PMID: 19760522
    9. TRAX is post-transcriptionally stabilized by TB-RBP and both proteins are needed for normal cell proliferation PMID: 14711818
    10. One region in TRAX showed weaker evidence for sex-specific associations of individual haplotypes with bipolar disorder in men. PMID: 15838535

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  • 亞細胞定位：
    Cytoplasm, perinuclear region. Golgi apparatus. Nucleus.
  • 蛋白家族：
    Translin family
  • 數據庫鏈接：

    HGNC: 12380

    OMIM: 602964

    KEGG: hsa:7257

    STRING: 9606.ENSP00000355599

    UniGene: Hs.13318



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