在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Transcription factor SOX-10 (SOX10)

  • 中文名稱:
    人SOX10重組蛋白
  • 貨號:
    CSB-YP022418HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人SOX10重組蛋白
  • 貨號:
    CSB-EP022418HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人SOX10重組蛋白
  • 貨號:
    CSB-EP022418HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人SOX10重組蛋白
  • 貨號:
    CSB-BP022418HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人SOX10重組蛋白
  • 貨號:
    CSB-MP022418HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    SOX10
  • Uniprot No.:
  • 別名:
    DOM; DOM; Dominant megacolon mouse human homolog of; MGC15649; PCWH; SOX 10; SOX10; SOX10_HUMAN; SRY (sex determining region Y) box 10; SRY (sex determining region Y) box 10; SRY box 10; SRY box containing gene 10; SRY related HMG box gene 10; SRY related HMG box gene 10; Transcription factor SOX 10; Transcription factor SOX-10; WS2E; WS4; WS4C
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full length protein
  • 表達區域:
    1-466
  • 氨基酸序列
    MAEEQDLSEV ELSPVGSEEP RCLSPGSAPS LGPDGGGGGS GLRASPGPGE LGKVKKEQQD GEADDDKFPV CIREAVSQVL SGYDWTLVPM PVRVNGASKS KPHVKRPMNA FMVWAQAARR KLADQYPHLH NAELSKTLGK LWRLLNESDK RPFIEEAERL RMQHKKDHPD YKYQPRRRKN GKAAQGEAEC PGGEAEQGGT AAIQAHYKSA HLDHRHPGEG SPMSDGNPEH PSGQSHGPPT PPTTPKTELQ SGKADPKRDG RSMGEGGKPH IDFGNVDIGE ISHEVMSNME TFDVAELDQY LPPNGHPGHV SSYSAAGYGL GSALAVASGH SAWISKPPGV ALPTVSPPGV DAKAQVKTET AGPQGPPHYT DQPSTSQIAY TSLSLPHYGS AFPSISRPQF DYSDHQPSGP YYGHSGQASG LYSAFSYMGP SQRPLYTAIS DPSPSGPQSH SPTHWEQPVY TTLSRP
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3. Transcriptional activator of MBP, via binding to the gene promoter.
  • 基因功能參考文獻:
    1. there have been a number of related reports that mutation of SOX10 will lead to Kallmann syndrome with deafness. PMID: 29726667
    2. phylogenetic analysis and three-dimensional modelling of the SOX10 protein confirmed that the c.1333delT heterozygous mutation was pathogenic, indicating that this mutation might constitute a candidate disease-causing mutation. PMID: 28128317
    3. Use of reliable positive and negative tissue controls is an important issue that must be addressed in any immunohistochemical staining reaction.4 SOX10 is a challenging marker in this sense, as no easy accessible tissues with consistent low-level expression have been identified at this time PMID: 28549040
    4. High SOX10 expression is associated with Basal Breast Cancers. PMID: 28216417
    5. Data show that depletion of SRY (sex determining region Y)-box 10 protein (SOX10) sensitizes mutant proto-oncogene proteins B-raf (BRAF) melanoma cells to RAF inhibitors in vitro and in vivo. PMID: 29295999
    6. SOX10 immunohistochemistry may be of utility in distinguishing some of the varying adnexal tumors from each other, and from basal cell carcinoma (BCC), but given the staining of both apocrine and eccrine tumors, does not seem to provide information as to their origins as either eccrine or apocrine tumors. PMID: 28343365
    7. Adenocarcinomas or adenomas derived from pigmented ciliary epithelium is distinguished from uveal melanoma by the absence of SOX10 expression and presence of the BRAF V600E mutation. PMID: 29059311
    8. Therefore, the mutant cannot transactivate the MITF promoter effectively, inhibiting melanin synthesis and leading to WS2. Our study confirmed haploinsufficiency as the underlying pathogenesis for WS2. PMID: 28893539
    9. Sox10 labeling is seen in a subset of metastatic triple-negative breast carcinomas, supporting its use as a marker of breast origin in this setting. PMID: 28843711
    10. SOX10 is useful in the differential diagnosis of salivary gland neoplasms. PMID: 27327192
    11. An extended immunohistochemical panel that includes beta-catenin and SOX10 helps to support the diagnosis of biphenotypic sinonasal sarcoma without the need for gene rearrangement studies. PMID: 27137987
    12. found that all SOX10-NL-positive cells expressed an early neural crest marker NGFR, however SOX10-NL-positive cells purified from differentiated hiPS cells progressively attenuate their NL-expression under proliferation PMID: 28107504
    13. The expression of the endogenous transcript is induced in a heterologous cell line by ectopically expressing SOX10, and is nearly ablated in Schwann cells by impairing SOX10 function. Intriguingly, overexpressing the two MTMR2 protein isoforms in HeLa cells revealed that both localize to nuclear puncta and the shorter isoform displays higher nuclear localization compared to the longer isoform PMID: 27466180
    14. This study assesses MYB, CD117 and SOX-10 expression in cutaneous adnexal tumors. PMID: 28098399
    15. Our zebrafish CHARGE model thus reveals important regulatory roles for Chd7 at multiple points of neural crest development viz., migration, fate choice and differentiation and we suggest that sox10 deregulation is an important driver of the neural crest-derived aspects of Chd7 dependent CHARGE syndrome. PMID: 27418670
    16. Data indicate that transcription factors Sox10 and Olig2 play key roles in oligodendrocytes (OLs) specification. PMID: 27785726
    17. SRY (sex determining region Y)-box 10 protein (SOX10) enhances nestin protein (NES) expression via directly binding to the promoter of NES. PMID: 28189679
    18. mutation is associated with distinctive phenotypic profile (association of anosmia and chronic constipation with SOX10 mutations) PMID: 28390600
    19. A low-level expression of Sox10 was significantly associated with high-level venous invasion by immunohistochemical evaluation, while it was significantly associated with high-level lymphatic permeation when analyzed by real-time PCR assay. PMID: 27943102
    20. SOX10 expression is elevated in serum of melanoma and vitiligo patients as compared to controls. PMID: 27110718
    21. Study provides evidence that the tumor suppressor Fbxw7alpha is the E3 ubiquitin ligase responsible for the degradation of SOX10, and suggests that reduced Fbxw7alpha might contribute to the upregulation of SOX10 in melanoma cells. PMID: 26461473
    22. Sox10 is expressed in many ovarian carcinomas PMID: 26951260
    23. we demonstrated that SOX10 is one of the most consistent markers of CD133+ stem-like ACC cells. Expression of SOX10 is also seen in other cancers, suggesting that they may contain similar stem-like cells. PMID: 27084744
    24. Despite the fact that the E248fs has a dominant-negative effect on SOX10, its reduced stability may down-regulate the transcription of MITF and decrease the synthesis of melanin PMID: 27454999
    25. SOX10-positivity rules out the diagnosis of ependymoma among other glial tumors with high confidence PMID: 26287936
    26. SOX-10 expression is exclusively specific for all cases of metastatic melanoma. PMID: 25611246
    27. This study demonstated that Shows no differences in expression level in ependymomas from Infants versus older children or amongiMolecular Subgroups. PMID: 26945037
    28. SOX10 mutations can mimic non-syndromic hearing impairment. PMID: 25256313
    29. our data imply that the same SOX10 mutations can underlie both typical Waardenburg syndrome and Kallmann Syndrome with deafness without skin/hair hypopigmentation, Hirschsprung disease, or neurological defects PMID: 26228106
    30. Subnuclear re-localization of SOX10 and p54NRB correlates with a unique neurological phenotype associated with SOX10 missense mutations. PMID: 26060192
    31. Our result confirm the thesis that heterozygous deletions at SOX10 is an important pathogenicity for Waardenburg syndrome type II. PMID: 26296878
    32. The use of SOX10 may increase the diagnostic accuracy of salivary gland oncocytic lesions on fine needle aspiration. PMID: 26619208
    33. Study shows that by uncoupling the effects of gain-of-function and haploinsufficiency in vivo, the effect of PCWH-causing SOX10 mutation is solely pathogenic in each SOX10-expressing cellular lineage in a dosage-dependent manner. PMID: 25959061
    34. Melanoma reprogramming involves thousands of genomic regulatory regions underlying the proliferative and invasive states, identifying SOX10/MITF and AP-1/TEAD as regulators, respectively. PMID: 25865119
    35. Identification of a rare dominant heterozygous SOX10 mutation c.621C>A in this family provided an efficient way to understand the causes of Waardenburg syndrome type II and improved genetic counseling. PMID: 25817900
    36. Sox10 is superior to S100 in the differential diagnosis of schwannoma and meningioma. PMID: 25265429
    37. reliable marker for detecting metastatic melanoma in sentinel lymph nodes PMID: 25356946
    38. Loss of SOX10 is associated with digestive cancers. PMID: 25301735
    39. we examined Sox10 expression in 5134 human neoplasms spanning a wide spectrum of neuroectodermal, mesenchymal, lymphoid, and epithelial tumors. PMID: 25724000
    40. Results show that SRY could be expressed in tissues of Hirschsprung patients. It binds to the promoter of RET gene by competing with SOX10 for its interaction with PAX3 and NKX2-1 repressing their transcriptional expression and RET's as well. PMID: 25267720
    41. Data indicate that SOX transcription factor SOX10 was expressed in 238 of 257 melanomas, including 50 of 51 of both spindle cell and desmoplastic melanomas. PMID: 25436903
    42. SH3TC2 is regulated by the transcription factors CREB and SOX10, define a regulatory SNP at this disease-associated locus and reveal SH3TC2 as a candidate modifier locus of CMT disease phenotypes. PMID: 24833716
    43. High SOX10 expression is associated with gangliocytic paraganglioma. PMID: 25562414
    44. This study reports on three independent families with SOX10 mutations predicted to result in the same missense mutation at the protein level. PMID: 24845202
    45. Sox10 (and Sox2) activate transcriptional elongation in Schwann cells by recruiting the positive transcription elongation factor b. PMID: 25524031
    46. Decreases in Sox10 expression levels and a loss of Sox10(+) cells in both mouse and human aged ears suggests an important role of Sox10 in the maintenance of structural and functional integrity of the lateral wall. PMID: 24887110
    47. haploinsufficiency of SOX10 may "unmask" subtler effects on expression or epistasis associated with variants in SOX10 targets (e.g., DHH), in its partners (e.g., PAX3, EGR2), and in genes with functional overlap (e.g., SOX8, SOX9). PMID: 24715709
    48. The novel heterozygous c.259-260delCT mutation in the SOX10 gene was considered to be the cause of Waardenburg syndrome PMID: 24735604
    49. SOX10 facilitates TCF4 to bind to beta-catenin and form a stable SOX10/TCF4/beta-catenin complex and trans-activate its downstream target gene in human hepatocellular carcinoma PMID: 25001176
    50. SOX-10 is a relatively reliable marker for staining cutaneous myoepitheliomas. PMID: 24329979

    顯示更多

    收起更多

  • 相關疾病:
    Waardenburg syndrome 2E (WS2E); Waardenburg syndrome 4C (WS4C); Peripheral demyelinating neuropathy, central dysmyelinating leukodystrophy, Waardenburg syndrome and Hirschsprung disease (PCWH)
  • 亞細胞定位:
    Cytoplasm. Nucleus. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side.
  • 組織特異性:
    Expressed in fetal brain and in adult brain, heart, small intestine and colon.
  • 數據庫鏈接:

    HGNC: 11190

    OMIM: 602229

    KEGG: hsa:6663

    STRING: 9606.ENSP00000354130

    UniGene: Hs.376984



主站蜘蛛池模板: 国产成人精品日本亚洲| 国内乱码一线二线三线| 在线观看的av免费网站| 老熟妇hd小伙子另类| 欧美黑吊大战白妞| 99精品久久精品一区二区| 国产成人无码免费看片软件| 国产内射999视频一区| 国产在线观看黄av免费| 最新精品露脸国产在线| 最美女人体内射精一区二区| 国精产品一区一区三区| 99久热在线精品视频观看| 97影院理论片手机在线观看| 亚洲成a人片77777国产| 野外被强j到高潮免费观看| 亚洲人色婷婷成人网站在线观看| 日本视频高清一道一区| 午夜时刻免费入口| 免费无码又爽又刺激高潮软件| 久久婷婷五月综合色俺也想去| 国内极度色诱视频网站| 久久久久国产精品嫩草影院| 国产精品96久久久久久| 久久久久日韩精品免费观看| 92午夜福利少妇系列| 国产成人精品免高潮在线观看| 亚洲精品乱码久久久久久蜜桃图片| 精品一卡二卡三卡| 亚拍精品一区二区三区探花 | 国产又色又爽又刺激视频| 玩弄少妇的肉体k8经典| 亚洲精品无码永久中文字幕| 天天狠天天透天干天天怕∴| 国产精品沙发午睡系列990531| 日产无码中文字幕av| 国产精品亚洲综合色区| 成 人 网 站 免费观看| 成人性生交片无码免费看| 18禁黄网站禁片免费观看不卡| 最新无码a∨在线观看|