在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Transcription factor AP-4 (TFAP4 BHLHC41)

Recombinant Human Transcription factor AP-4 (TFAP4 BHLHC41)

  • 中文名稱：
  • 貨號：
    CSB-YP023419HU1
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-EP023419HU1
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-EP023419HU1-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-BP023419HU1
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-MP023419HU1
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    TFAP4
  • Uniprot No.：
  • 別名：
    Transcription factor AP-4; Activating enhancer-binding protein 4; Class C basic helix-loop-helix protein 41; bHLHc41; TFAP4 BHLHC41
  • 種屬：
    Homo sapiens (Human)
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

相關(guān)產(chǎn)品

靶點詳情

  • 功能：
    Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.
  • 基因功能參考文獻：
    1. these findings support a plausible mechanism by which the AP4/L-plastin axis is regulated by the PI3K/AKT pathway in human prostate cancer (PCa)and may represent a novel therapeutic target in PCa treatment. PMID: 28981098
    2. Results show that AP4 is overexpressed in primary carcinoma compared with the non-cancerous mucosa and is up-regulated in EMT in colorectal cancer (CRC) cells. Its overexpression is correlated with liver metastasis in CRC and poor outcome. Also, The study show that USP22 binds to the promoter region of AP4 to activate its transcription. PMID: 28427243
    3. Data show that transcription factor activating enhancer binding protein-4 (TFAP4) is a direct transcriptional target of MYCN in neuroblastoma and that high levels of this transcription factor are associated with poor clinical outcome in this disease. PMID: 27448979
    4. Depletion of either Arl5b or AP4 results in the accumulation of APP. PMID: 28000370
    5. results indicate that AP4 is a central mediator and coordinator of cell cycle progression PMID: 25261373
    6. the 16 SNP variants studied in the genes encoding the four units of AP-4 do not have a major role in overall CP, but SNP rs1217401 of AP4B1 is significantly associated with the risk of CP as a sequela of neonatal HIE in the Chinese population. PMID: 24065543
    7. betaTrCP-dependent degradation of TFAP4 is required for the fidelity of mitotic division PMID: 24500709
    8. Senescence caused by AP4-deficiency was prevented by depletion of p16 and/or p21, demonstrating that these factors mediate senescence caused by AP4 loss. PMID: 23949224
    9. Elevated AP4 expression in primary colorectal cancer (CRC) significantly correlated with liver metastasis and poor patient survival. Findings imply AP4 as a new regulator of epithelial-mesenchymal transition that contributes to metastatic processes in CRC PMID: 23752226
    10. findings provide evidence that a high expression level of AP-4 serves as a biomarker for poor prognosis for hepatocellular carcinoma PMID: 23055200
    11. The expression of AP-4 was silenced by the siRNAs transfection. PMID: 22615908
    12. Overexpression of AP-4 is associated with gastric carcinoma. PMID: 21336989
    13. in serum- or IGF-1-stimulated breast cancer MCF-7 cells, JNK induces SHP1 expression through the binding of AP-4 and RFX-1 transcription factors to the epithelial tissue-specific SHP1 promoter. PMID: 21719561
    14. Activator protein-4 expression was associated with the expression of matrix metalloproteinase-9 and vascular endothelial growth factor in the advanced colorectal cancer. PMID: 18480385
    15. Docking studies showed that the ATF4 DpSGIXXpSXE motif fits the binding pocket of beta-TrCP through an S-turning conformation. PMID: 18052253
    16. c-MYC directly regulates the expression of AP4 via CACGTG motifs in the first intron of the AP4 gene. PMID: 18818310
    17. AP-4 participates in a transcriptional-regulating complex at the HDM2-P2 promoter in response to DNA damage. PMID: 19505873

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11745

    OMIM: 600743

    KEGG: hsa:7023

    STRING: 9606.ENSP00000204517

    UniGene: Hs.513305



主站蜘蛛池模板： 精品一区二区不卡无码av| 破了亲妺妺的处免费视频国产| 天堂www中文在线资源| 国产一区二区在线视频| 中文字幕v亚洲日本在线| 国产成人午夜在线视频a站| 精产一二三产区m553| 久久精品中文字幕一区二区三区| 亚洲国产欧美一区点击进入| 久久视热这里只有精品| 丰满少妇人妻无码专区| 精品无码一区二区三区爱欲九九 | www亚洲精品久久久乳| 国产亚洲精品久久久ai换脸| 午夜丰满少妇性开放视频| 欧洲亚洲色一区二区色99| 综合激情丁香久久狠狠| 成年站免费网站看v片在线| 国产95在线 | 亚洲| 日本大片免a费观看视频| 国产情侣疯狂作爱系列| 天堂中文在线8最新版地址| 亚洲中文字幕无码中文字在线| 香港日本三级亚洲三级| 久久精品国产国产精品四凭 | 忘忧草日本在线www| 国产成人无码a区在线观看视频app | 免费裸体无遮挡黄网站免费看| av午夜久久蜜桃传媒软件| 久久中文字幕乱码久久午夜| 久久天天躁狠狠躁夜夜2019| 欧美丰满熟妇bbbbbb百度| 久久人人爽人人爽人人片dvd| 婷婷五月综合国产激情| 久久天天躁狠狠躁夜夜2020一| 自拍日韩亚洲一区在线| 少妇spa推油被扣高潮| 精品国产一区二区三区四区| 亚洲国产精品一区二区久久hs| 无码中文字幕av免费放| 性欧美丰满熟妇xxxx性|