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  4. Recombinant Human Transcription elongation regulator 1 (TCERG1), partial

Recombinant Human Transcription elongation regulator 1 (TCERG1), partial

  • 中文名稱：
    人TCERG1重組蛋白
  • 貨號：
    CSB-YP023291HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人TCERG1重組蛋白
  • 貨號：
    CSB-EP023291HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人TCERG1重組蛋白
  • 貨號：
    CSB-EP023291HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人TCERG1重組蛋白
  • 貨號：
    CSB-BP023291HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人TCERG1重組蛋白
  • 貨號：
    CSB-MP023291HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    TCERG1
  • Uniprot No.：
  • 別名：
    CA 150; Co activator of 150 kDa; Coactivator of 150 kDa; MGC133200; TAF 2S; TAF2S; TATA box binding protein (TBP) associated factor RNA polymerase II S 150kD; TATA box binding protein associated factor 2S; TATA box binding protein associated factor RNA polymerase II S 150kD; TATA box-binding protein-associated factor 2S; TBP-associated factor, RNA polymerase II, 150-kD; TCERG 1; TCERG1; TCRG1_HUMAN; Transcription elongation regulator 1; Transcription factor CA 150; Transcription factor CA150; Urn1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter.
  • 基因功能參考文獻：
    1. TCERG1 affects expression of multiple mRNAs involved in neuron projection development. PMID: 27844289
    2. The QA repeat domain of TCERG1 is required for relocalization of CEBPalpha. PMID: 26264132
    3. TCERG1 binds independently to elongation and splicing complexes, thus performing their coupling by transient interactions rather than by stable association with one or the other complexes. PMID: 26873599
    4. TCERG1 sensitizes a cell to apoptotic agents, thus promoting apoptosis by regulating the alternative splicing of both the Bcl-x and Fas/CD95 genes. PMID: 26462236
    5. This study reveals that TCERG1 regulates HIV-1 transcriptional elongation by increasing the elongation rate of RNAPII and phosphorylation of Ser 2 within the carboxyl-terminal domain. PMID: 24165037
    6. Specific interaction of the transcription elongation regulator TCERG1 with RNA polymerase II requires simultaneous phosphorylation at Ser2, Ser5, and Ser7 within the carboxyl-terminal domain repeat. PMID: 23436654
    7. The FF4 and FF5 domains of transcription elongation regulator 1 (TCERG1) target proteins to the periphery of speckles. PMID: 22453921
    8. We propose that TCERG1 modulates the elongation rate of RNAPII to relieve pausing, thereby activating the proapoptotic Bcl-x(S) 5' splice site. PMID: 22158966
    9. TCERG1 can inhibit C/EBPalpha activity regardless of the latter's location in the nucleus PMID: 21503969
    10. mutation of the SUMO acceptor lysine residues enhanced TCERG1 transcriptional activity, indicating that SUMO modification negatively regulates TCERG1 transcriptional activity PMID: 20215116
    11. Specific alleles in GluR6 and CA150 locus were only observed in HD patients. PMID: 12821179
    12. Results suggest an essential role of WW/FF domain-containing factors such as FBP11 and CA150 in pre-mRNA splicing that likely occurs in concert with transcription in vivo. PMID: 15456888
    13. CA150 is a co-repressor of C/EBP proteins and provides a possible mechanism for how C/EBPalpha can repress transcription of specific genes PMID: 16644732
    14. Sequences located at both the amino and carboxyl regions of CA150 are required to assemble transcription/splicing complexes, which may be involved in the coupling of those processes. PMID: 16782886
    15. GRIN2A and TCERG1 may show true association with residual age of onset for Huntington's disease in genetic association tests in 443 affected people from a large set of kindreds from Venezuela. PMID: 17018562
    16. The interferon consensus sequence-binding protein (ICSBP/IRF8) represses PTPN13 gene transcription in differentiating myeloid cells PMID: 18187414
    17. Data provide the first crystal structure of an FF domain and insights into the tandem nature of the FF domains and suggest that, in addition to protein binding, FF domains might be involved in DNA binding. PMID: 19660470
    18. Data gave a model for FF domain organization within tandem arrays suggests a general mechanism by which individual FF domains can manoeuvre to achieve optimal recognition of flexible binding partners, such as the intrinsically-disordered phosphoCTD PMID: 19715701

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  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Detected in brain neurons.
  • 數據庫鏈接：

    HGNC: 15630

    OMIM: 605409

    KEGG: hsa:10915

    STRING: 9606.ENSP00000296702

    UniGene: Hs.443465



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