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Recombinant Human Tetratricopeptide repeat protein 21B (TTC21B), partial

  • 中文名稱:
    人TTC21B重組蛋白
  • 貨號:
    CSB-YP767200HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人TTC21B重組蛋白
  • 貨號:
    CSB-EP767200HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人TTC21B重組蛋白
  • 貨號:
    CSB-EP767200HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人TTC21B重組蛋白
  • 貨號:
    CSB-BP767200HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人TTC21B重組蛋白
  • 貨號:
    CSB-MP767200HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    TTC21B
  • Uniprot No.:
  • 別名:
    TTC21B; IFT139; KIAA1992; Nbla10696; Tetratricopeptide repeat protein 21B; TPR repeat protein 21B; Intraflagellar transport 139 homolog
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs). Essential for retrograde trafficking of IFT-1, IFT-B and GPCRs. Negatively modulates the SHH signal transduction.
  • 基因功能參考文獻:
    1. Case Reports: 3 novel TTC21B mutations in two Chinese pediatric nephronophthisis-related ciliopathies cases that both presented with end-stage renal disease. PMID: 28124483
    2. TTC21B mutation is associated with glomerular and cystic kidney diseases. PMID: 26940125
    3. Exome sequencing and further CRB2 analysis revealed that both siblings are compound heterozygotes for CRB2 mutations p.N800K and p.Gly1036Alafs*43, and heterozygous for a deleterious splice variant in the ciliopathy gene TTCB21 PMID: 26925547
    4. We demonstrated that the TTC21B gene product IFT139, an intraflagellar transport-A component, mainly localizes at the base of the primary cilium in developing podocytes from human fetal tissue and in undifferentiated cultured podocytes. PMID: 24876116
    5. TTC21B contributes pathogenic alleles to approximately 5% of ciliopathy cases. Our data illustrate how genetic lesions can be both causally associated with diverse ciliopathies and interact in trans with other disease-causing genes PMID: 21258341

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  • 相關疾病:
    Nephronophthisis 12 (NPHP12); Short-rib thoracic dysplasia 4 with or without polydactyly (SRTD4); Joubert syndrome 11 (JBTS11)
  • 亞細胞定位:
    Cytoplasm, cytoskeleton, cilium axoneme.
  • 蛋白家族:
    TTC21 family
  • 數據庫鏈接:

    HGNC: 25660

    OMIM: 612014

    KEGG: hsa:79809

    STRING: 9606.ENSP00000243344

    UniGene: Hs.310672



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