在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Terminal uridylyltransferase 4 (ZCCHC11), partial

  • 中文名稱:
    人ZCCHC11重組蛋白
  • 貨號:
    CSB-YP719419HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人ZCCHC11重組蛋白
  • 貨號:
    CSB-EP719419HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人ZCCHC11重組蛋白
  • 貨號:
    CSB-EP719419HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人ZCCHC11重組蛋白
  • 貨號:
    CSB-BP719419HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人ZCCHC11重組蛋白
  • 貨號:
    CSB-MP719419HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    ZCCHC11
  • Uniprot No.:
  • 別名:
    DKFZp779C1943; EC 2.7.7.52; FLJ42878; KIAA0191; PAP associated domain containing 3; PAPD3; Terminal uridylyltransferase 4; TUT4; TUT4_HUMAN; TUTase 4; ZCCHC 11; Zcchc11; Zinc finger CCHC domain containing 11; Zinc finger CCHC domain containing protein 11; Zinc finger CCHC domain-containing protein 11
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay. Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth. Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also functions as an integral regulator of microRNA biogenesis using 3 different uridylation mechanisms. Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency. Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression. In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing. Adds oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species. May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation. Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult. TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules.
  • 基因功能參考文獻:
    1. The authors found that TUT4(7) utilize two multidomain functional modules during the switch from either promoting expression of let-7 microRNA (monoU) or marking it for degradation (oligoU). PMID: 28671666
    2. For overall breast cancer risk, three single-nucleotide polymorphisms (SNPs) in miRNA biogenesis genes DROSHA rs78393591 (OR = 0.69, 95 % CI: 0.55-0.88, P = 0.003), ESR1 rs523736 (OR = 0.88, 95 % CI: 0.82-0.95, P = 3.99 x 10(-4)), and ZCCHC11 rs114101502 (OR = 1.33, 95 % CI: 1.11-1.59, P = 0.002), and one SNP in primary miRNA sequence (rs116159732 in miR-6826, OR = 0.74, 95 % CI: 0.63-0.89, P = 0.001) were found to have s PMID: 27380242
    3. Data indicate that some of the small molecules were validated as specific inhibitors of 3' terminal uridylyl transferase (TUTase) Zcchc11 (TUT4) activity. PMID: 26114892
    4. Study identified TUT4 and TUT7 as uridylyl transferases for poly(A)+ mRNAs in humans and delineated in detail the action mechanism and molecular function of uridylation in the mRNA decay pathway. PMID: 25480299
    5. miR-26a directly targets Lin28B and Zcchc11-two critical repressors of let-7 maturation. PMID: 24056962
    6. Study identified TUT7, TUT4, and TUT2 as novel components of the miRNA biogenesis pathway. PMID: 23063654
    7. Lin28 uses two different TUTases to control let-7 expression . PMID: 22898984
    8. Terminal uridyltransferase enzyme Zcchc11 promotes cell proliferation independent of its uridyltransferase activity PMID: 22006926
    9. This study uncovers the role of TUT4 and Lin28 as specific suppressors of microRNA biogenesis, which has implications for stem cell research and cancer biology. PMID: 19703396
    10. We propose that ZCCHC11 is a unique TLR signal regulator, which interacts with TIFA after LPS treatment and suppresses the TRAF6-dependent activation of NF-kappaB. PMID: 16643855
    11. Zcchc11 fine tunes IL-6 production by uridylating miR-26a. PMID: 19701194
    12. TUT4 adds an oligouridine tail to the pre-let-7, which blocks Dicer processing. Knockdown of TUT4 and Lin28 reduces the level of stem cell markers PMID: 19703396

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm. Cytoplasm, Cytoplasmic ribonucleoprotein granule.
  • 蛋白家族:
    DNA polymerase type-B-like family
  • 數據庫鏈接:

    HGNC: 28981

    OMIM: 613692

    KEGG: hsa:23318

    STRING: 9606.ENSP00000257177

    UniGene: Hs.655407



主站蜘蛛池模板: 99在线 | 亚洲| 天天综合色天天综合色hd| 人人爽人人添人人超| 在线观看片免费视频无码| 成人性做爰aaa片免费| 国产精品99久久精品爆乳| 欧美性猛交xxxx免费看| 99久久国产精品免费高潮| 色欲天天天综合网| 久久草莓香蕉频线观| 婷婷综合久久中文字幕| 国产成人精品日本亚洲第一区| 99久久国产宗和精品1上映| 国产精品点击进入在线影院高清 | 2021国产精品自在自线| 人人妻人人做人人爽| 亚洲精品久久久久久成人| 国产亚洲aⅴ在线电影| 污污污污污污污网站污| 中文字幕乱码人妻无码久久| 免费看男女做爰爽爽视频| 亚洲韩国日本高清一区| 高清乱码一区二区三区| 日韩av片无码一区二区不卡电影| 特级做a爰片毛片免费看无码| 青春草在线视频免费观看| 国产在线无码一区二区三区| yy111111少妇影院无码| 国产av无码国产av毛片| 国产精品国产三级国产a| 性色高清xxxxx厕所偷窥| 亚洲日韩成人无码不卡网站 | 中文字幕 乱码 中文乱码视频| 国产精品无码aⅴ嫩草| 精品久久久久久中文字幕| 国内大量揄拍人妻在线视频| 欧美xxxxx在线观看| 成人一区二区免费视频| 国产成人综合久久亚洲精品| 中文字幕av久久激情亚洲精品 | 毛片完整版的免费观看|