在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ZCCHC11 Antibody

ZCCHC11 Antibody

  • 中文名稱：
    ZCCHC11兔多克隆抗體
  • 貨號：
    CSB-PA026374GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    ZCCHC11
  • 別名：
    DKFZp779C1943 antibody; EC 2.7.7.52 antibody; FLJ42878 antibody; KIAA0191 antibody; PAP associated domain containing 3 antibody; PAPD3 antibody; Terminal uridylyltransferase 4 antibody; TUT4 antibody; TUT4_HUMAN antibody; TUTase 4 antibody; ZCCHC 11 antibody; Zcchc11 antibody; Zinc finger CCHC domain containing 11 antibody; Zinc finger CCHC domain containing protein 11 antibody; Zinc finger CCHC domain-containing protein 11 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Human ZCCHC11
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay. Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth. Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also functions as an integral regulator of microRNA biogenesis using 3 different uridylation mechanisms. Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency. Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression. In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing. Adds oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species. May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation. Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult. TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules.
  • 基因功能參考文獻：
    1. The authors found that TUT4(7) utilize two multidomain functional modules during the switch from either promoting expression of let-7 microRNA (monoU) or marking it for degradation (oligoU). PMID: 28671666
    2. For overall breast cancer risk, three single-nucleotide polymorphisms (SNPs) in miRNA biogenesis genes DROSHA rs78393591 (OR = 0.69, 95 % CI: 0.55-0.88, P = 0.003), ESR1 rs523736 (OR = 0.88, 95 % CI: 0.82-0.95, P = 3.99 x 10(-4)), and ZCCHC11 rs114101502 (OR = 1.33, 95 % CI: 1.11-1.59, P = 0.002), and one SNP in primary miRNA sequence (rs116159732 in miR-6826, OR = 0.74, 95 % CI: 0.63-0.89, P = 0.001) were found to have s PMID: 27380242
    3. Data indicate that some of the small molecules were validated as specific inhibitors of 3' terminal uridylyl transferase (TUTase) Zcchc11 (TUT4) activity. PMID: 26114892
    4. Study identified TUT4 and TUT7 as uridylyl transferases for poly(A)+ mRNAs in humans and delineated in detail the action mechanism and molecular function of uridylation in the mRNA decay pathway. PMID: 25480299
    5. miR-26a directly targets Lin28B and Zcchc11-two critical repressors of let-7 maturation. PMID: 24056962
    6. Study identified TUT7, TUT4, and TUT2 as novel components of the miRNA biogenesis pathway. PMID: 23063654
    7. Lin28 uses two different TUTases to control let-7 expression . PMID: 22898984
    8. Terminal uridyltransferase enzyme Zcchc11 promotes cell proliferation independent of its uridyltransferase activity PMID: 22006926
    9. This study uncovers the role of TUT4 and Lin28 as specific suppressors of microRNA biogenesis, which has implications for stem cell research and cancer biology. PMID: 19703396
    10. We propose that ZCCHC11 is a unique TLR signal regulator, which interacts with TIFA after LPS treatment and suppresses the TRAF6-dependent activation of NF-kappaB. PMID: 16643855
    11. Zcchc11 fine tunes IL-6 production by uridylating miR-26a. PMID: 19701194
    12. TUT4 adds an oligouridine tail to the pre-let-7, which blocks Dicer processing. Knockdown of TUT4 and Lin28 reduces the level of stem cell markers PMID: 19703396

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm. Cytoplasm, Cytoplasmic ribonucleoprotein granule.
  • 蛋白家族：
    DNA polymerase type-B-like family
  • 數據庫鏈接：

    HGNC: 28981

    OMIM: 613692

    KEGG: hsa:23318

    STRING: 9606.ENSP00000257177

    UniGene: Hs.655407



主站蜘蛛池模板： 亚洲精品无码中文久久字幕| 性欧美牲交在线视频| 国产无限次数成版人视频在线 | 女女同性av片在线观看免费| 亚洲性色成人av| 日本中文一区二区三区亚洲| 亚洲综合一区二区三区无码| 国产成人a人亚洲精品无码| 亚洲欧美自拍制服另类图区| 久久精品超碰av无码| 日本边添边摸边做边爱的网站| 成人性做爰aaa片免费看| 亚洲成av人片天堂网久久| 国产人成午夜免电影费观看| 中国女人做爰视频| 99久久久无码国产精品古装| 亚洲成av人无码中文字幕| 久久国产加勒比精品无码| 乱熟女高潮一区二区在线| 亚洲欧洲av无码专区| 免费视频好湿好紧好大好爽| 日本精品人妻无码免费大全| 国产欧美另类久久精品蜜芽| 综合自拍亚洲综合图区欧美 | 性欧美老人牲交xxxxx视频| 2018亚洲а∨天堂| 成人三级视频在线观看一区二区| 隔壁人妻偷人bd中字| 国产日韩精品欧美一区喷水| 末成年毛片在线播放| 国产精品日本一区二区不卡视频| 精品无码中文视频在线观看| 欧美成妇人吹潮在线播放| 亚洲一区二区三区国产精品无码| 大乳丰满人妻中文字幕日本| 成人区精品一区二区不卡| 欧洲专线一区二区三区| 人妻巨大乳一二三区| 人人爽人人爽人人片av| 国语对白刺激精品视频| 风流少妇又紧又爽又丰满|