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  4. Recombinant Human Telomere-associated protein RIF1 (RIF1), partial

Recombinant Human Telomere-associated protein RIF1 (RIF1), partial

  • 中文名稱：
    人RIF1重組蛋白
  • 貨號：
    CSB-YP716414HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人RIF1重組蛋白
  • 貨號：
    CSB-EP716414HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人RIF1重組蛋白
  • 貨號：
    CSB-EP716414HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人RIF1重組蛋白
  • 貨號：
    CSB-BP716414HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人RIF1重組蛋白
  • 貨號：
    CSB-MP716414HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    DKFZp781N1478; FLJ10599; FLJ11269 ; FLJ12870; Rap1 interacting factor 1; Rap1 interacting factor 1 homolog; RAP1 interacting factor homolog ; RAP1 interacting factor homolog (yeast); Rap1-interacting factor 1 homolog; Receptor interacting factor 1; RIF 1; RIF1; RIF1 isoform 4 ; RIF1_HUMAN; Telomere associated protein RIF 1; Telomere associated protein RIF1; Telomere-associated protein RIF1; Telomeric protein RIF 1; Telomeric protein RIF1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs. In response to DNA damage, interacts with ATM-phosphorylated TP53BP1. Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs. Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs. In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase. Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs. Promotes NHEJ of dysfunctional telomeres.
  • 基因功能參考文獻：
    1. Upregulation of RIF1 correlates with poor prognosis in Epithelial Ovarian Cancer. PMID: 29719287
    2. Data suggest that SCAI inhibits RIF1 function to allow BRCA1-mediated repair, which possibly includes alt-NHEJ and resection-dependent NHEJ in G1, as well as HDR in S/G2. PMID: 28700933
    3. 53BP1/RIF1 has a role in limiting BRCA1/CtIP-mediated end resection to control double strand break repair pathway choice PMID: 27494840
    4. Rif1 can mediate MCM dephosphorylation at replication forks and that the stability of dephosphorylated replisomes strongly depends on Chk1 activity. PMID: 28273463
    5. DDX1, a RNA helicase also implicated in DSB repair, interacts with RIF1. Recruitment of DDX1 to DSBs is dependent on RIF1. DDX1 and RIF1 have different nucleic acid requirements for accumulation at DSBs, with RNA-DNA hybrids required for DDX1 accrual at DSBs, and single-strand RNA required for accumulation of RIF1 at these sites. PMID: 28544931
    6. In pancreatic cancer cells, RIF1 gene expression in the stem cell-positive cell line was 256 times that seen in the stem cell-negative cell line. RIF1 may be one of the genes that plays an important role in the diagnoses and therapeutic treatment of pancreatic cancer PMID: 27917791
    7. These data reveal a thus far unrecognized function for Rif1 in the resolution of ultrafine DNA bridges during anaphase to protect genomic integrity. PMID: 26256213
    8. RIF1 is an important component in DNA damage response signaling. [Review] PMID: 24462468
    9. RIF1 not only acts downstream of 53BP1 and counteracts BRCA1-mediated end resection but also has a secondary role in promoting BLM function in DNA repair. PMID: 23486525
    10. RIF1 as the critical effector of 53BP1 during DSB repair PMID: 23333306
    11. Rif1 plays crucial roles in determining the replication timing domain structures in human cells through regulating higher-order chromatin architecture PMID: 22850674
    12. Rif1 functions in the intra-S-phase checkpoint that serves to slow down DNA synthesis when DNA damage has occurred. PMID: 15342490
    13. In telophase, hRif1 localized to chromosomes, and in interphase, it was intranuclear. These results define a novel subcellular localization behavior for hRif1 during the cell cycle. PMID: 15583028
    14. High RIF1 expression is associated with breast tumors. PMID: 19483192

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  • 亞細胞定位：
    Nucleus. Chromosome. Chromosome, telomere. Cytoplasm, cytoskeleton, spindle.
  • 蛋白家族：
    RIF1 family
  • 組織特異性：
    Highly expressed in testis.
  • 數據庫鏈接：

    HGNC: 23207

    OMIM: 608952

    KEGG: hsa:55183

    STRING: 9606.ENSP00000243326

    UniGene: Hs.536537



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