在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Telethonin (TCAP)

Recombinant Human Telethonin (TCAP)

  • 中文名稱：
    人TCAP重組蛋白
  • 貨號：
    CSB-YP023264HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人TCAP重組蛋白
  • 貨號：
    CSB-EP023264HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人TCAP重組蛋白
  • 貨號：
    CSB-BP023264HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人TCAP重組蛋白
  • 貨號：
    CSB-MP023264HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    19 kDa sarcomeric protein; CMD1N; CMH25; LGMD2G; Limb girdle muscular dystrophy 2G (autosomal recessive); T-cap; Tcap; TELE; Telethonin; TELT_HUMAN; Titin cap protein; Titin-cap
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-167
  • 氨基酸序列
    MATSELSCEV SEENCERREA FWAEWKDLTL STRPEEGCSL HEEDTQRHET YHQQGQCQVL VQRSPWLMMR MGILGRGLQE YQLPYQRVLP LPIFTPAKMG ATKEEREDTP IQLQELLALE TALGGQCVDR QEVAEITKQL PPVVPVSKPG ALRRSLSRSM SQEAQRG
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk.
  • 基因功能參考文獻：
    1. based on the crystal structure in which Z1Z2 and telethonin1-90 assemble into a 2:1 complex, a single chain fusion protein was designed, comprising two Z1Z2 modules that are connected by flexible linkers N- and C-terminally of the telethonin1-90. Expression of this fusion protein, named ZTZ, affords high yields of soluble expressed and purified protein PMID: 28811266
    2. Data indicate LGMD2G protein TCAP association with limb girdle muscular dystrophy 2G (LGMD2G). PMID: 25055047
    3. Report TCAP mutations in dilated cardiomyopathy. PMID: 24037902
    4. cardiac telethonin is constitutively bis-phosphorylated and suggest that such phosphorylation is critical for normal telethonin function, which may include maintenance of transverse tubule organization and intracellular Ca(2+) transients. PMID: 24280220
    5. This study identified no pathogenic mutations in BAG3, MATR3, PTRF or TCAP in Australian muscular dystrophy. PMID: 21683594
    6. reduced expression of dystrophin and titin is associated with the pathophysiology of dilated cardiomyopathy, and TNF-alpha may modulate the expression of these proteins via NF-kappaB pathway. PMID: 20373002
    7. Genetic studies of tcap in zebrafish suggested that pathogenesis in LGMD2G is due to a disruption of sarcomere-T-tubular interaction, but not of sarcomere assembly per se. PMID: 19679566
    8. review of telethonin and other new proteins of the Z-disc of skeletal muscle PMID: 11699871
    9. telethonin protein levels seems to be at least in part regulated by neuronal activity and is thus linked to the dynamic control of myofibrillogenesis and muscle turnover in human skeletal muscle. PMID: 11763198
    10. telethonin may play a role in linking titin filaments at the Z-disk periphery PMID: 12446666
    11. TCAP mutations identified which are associated with hypertrophic cardiomyopathy. PMID: 15582318
    12. The titin Z1Z2-telethonin complex resist considerable mechanical force through beta strand crosslinking, suggesting that telethonin is an important component of the N-terminal titin anchor. PMID: 16531234
    13. A dimer of two titin/telethonin complexes is formed within the crystal environment, potentially indicating the formation of higher oligomers. PMID: 16713295
    14. Hypertension induced expression of prohypertrophic BMP10, and the hypertrophic effect of BMP10 was modulated, at least in part, by its binding to Tcap at the Z disc. PMID: 17921333
    15. telethonin is a sodium channel-interacting protein, and its mutations can alter Na(v)1.5 kinetics and may play a role in intestinal pseudo-obstruction PMID: 18408010
    16. Telethonin might be involved in CVB3-mediated cell damage and in the resulting cardiac dysfunction due to the interaction with Siva. PMID: 18849585
    17. Oncogenomic recombination hotspot around the PPP1R1B-STARD3-TCAP-PNMT-PERLD1-ERBB2-C17orf37-GRB7 amplicon at human chromosome 17q12 is closely linked to evolutionary recombination hotspot around the GSDML-GSDM locus. PMID: 15010812

    顯示更多

    收起更多

  • 相關疾病：
    Cardiomyopathy, familial hypertrophic 25 (CMH25); Limb-girdle muscular dystrophy 2G (LGMD2G)
  • 亞細胞定位：
    Cytoplasm, myofibril, sarcomere.
  • 組織特異性：
    Heart and skeletal muscle.
  • 數據庫鏈接：

    HGNC: 11610

    OMIM: 601954

    KEGG: hsa:8557

    STRING: 9606.ENSP00000312624

    UniGene: Hs.77628



主站蜘蛛池模板： 国产男女免费完整视频网页| 荫蒂添的好舒服视频囗交| 乱子轮熟睡1区| 国产亚洲精品久久久美女18黄| 麻豆自媒体 一区 二区| 第一亚洲中文久久精品无码| 狠狠躁天天躁无码中文字幕| 青草草在线视频永久免费| 大地资源中文第3页| 精品系列无码一区二区三区 | 啪一啪射一射插一插| 国产成人精品视频ⅴa片软件竹菊 免费精品99久久国产综合精品 | 亚洲国产av无码精品| 国产成a人亚洲精品无码樱花| 日韩精品一卡2卡三卡4卡| 国产成人精品视觉盛宴| 国产亚洲精品久久久久久老妇小说| 国产熟妇另类久久久久| 黑人巨茎大战欧美白妇| 乱人伦视频中文字幕| 射精区-区区三区| 国产精品一线二线三线| 色婷婷av一区二区三区之红樱桃 | 日99久9在线 | 免费| 中文字幕乱码在线人视频| 中日av乱码一区二区三区乱码| 中文字幕av伊人av无码av| 一区二三区国产好的精华液o9| 国产精品久久久久久久久绿色| 无码 制服 丝袜 国产 另类| 精品无人区卡一卡二卡三乱码| 欧美性猛交xxx嘿人猛交| 他掀开裙子把舌头伸进去添视频| 国产小呦泬泬99精品| 精品国际久久久久999| 久久久亚洲欧洲日产国码二区| 久久99精品国产99久久6不卡| 亚洲一区精品二人人爽久久| 国产免费一卡二卡三卡四卡| 欧美精品亚洲精品日韩专区| 国产精品夜色一区二区三区|