在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Syntaxin-binding protein 2 (STXBP2)

Recombinant Human Syntaxin-binding protein 2 (STXBP2)

  • 中文名稱：
    人STXBP2重組蛋白
  • 貨號(hào)：
    CSB-YP618999HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人STXBP2重組蛋白
  • 貨號(hào)：
    CSB-EP618999HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人STXBP2重組蛋白
  • 貨號(hào)：
    CSB-EP618999HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人STXBP2重組蛋白
  • 貨號(hào)：
    CSB-BP618999HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人STXBP2重組蛋白
  • 貨號(hào)：
    CSB-MP618999HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    STXBP2
  • Uniprot No.：
  • 別名：
    FHL5; Hunc18b; MUNC18 2; pp10122; Protein unc-18 homolog 2; Protein unc-18 homolog B; STXB2_HUMAN; Stxbp2; syntaxin binding protein 2; Syntaxin-binding protein 2; Unc-18B; UNC18 2; Unc18-2; UNC18B
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達(dá)區(qū)域：
    1-593
  • 氨基酸序列
    MAPSGLKAVV GEKILSGVIR SVKKDGEWKV LIMDHPSMRI LSSCCKMSDI LAEGITIVED INKRREPIPS LEAIYLLSPT EKSVQALIKD FQGTPTFTYK AAHIFFTDTC PEPLFSELGR SRLAKVVKTL KEIHLAFLPY EAQVFSLDAP HSTYNLYCPF RAEERTRQLE VLAQQIATLC ATLQEYPAIR YRKGPEDTAQ LAHAVLAKLN AFKADTPSLG EGPEKTRSQL LIMDRAADPV SPLLHELTFQ AMAYDLLDIE QDTYRYETTG LSEAREKAVL LDEDDDLWVE LRHMHIADVS KKVTELLRTF CESKRLTTDK ANIKDLSQIL KKMPQYQKEL NKYSTHLHLA DDCMKHFKGS VEKLCSVEQD LAMGSDAEGE KIKDSMKLIV PVLLDAAVPA YDKIRVLLLY ILLRNGVSEE NLAKLIQHAN VQAHSSLIRN LEQLGGTVTN PGGSGTSSRL EPRERMEPTY QLSRWTPVIK DVMEDAVEDR LDRNLWPFVS DPAPTASSQA AVSARFGHWH KNKAGIEARA GPRLIVYVMG GVAMSEMRAA YEVTRATEGK WEVLIGSSHI LTPTRFLDDL KALDKKLEDI ALP
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells.
  • 基因功能參考文獻(xiàn)：
    1. Neonatal platelets exhibit low levels of the Stx11-Munc18b complex (essential component of the SNARE machinery) and of beta1-tubulin. These developmental deficiencies are associated with defects in platelet adhesion, spreading and secretion. PMID: 29044293
    2. Among these nine polymorphisms, rs188212047 [G/T (L212F)] of STXBP2 was significantly (dominant model; P = 4.84 x 10-8; odds ratio, 2.94) associated with myocardial infarction. STXBP2 may thus be a novel susceptibility locus for myocardial infarction in Japanese. PMID: 28380445
    3. STXBP2 Gene Polymorphism is associated with Hemophagocytic Lymphohistocytosis. PMID: 27513731
    4. Mutation in STXBP2 gene is associated with hemophagocytic lymphohistiocytosis. PMID: 27781387
    5. Data show that Munc18b overexpression increased fusion of not only newcomer secretory granule (SG), but also predocked SGs in type-2 diabetes (T2D) human and Goto-Kakizaki Rat Islets. PMID: 28163042
    6. two novel mutations of STXBP2: c.184A>G and c.577A>C. c.184A>G (p.Asn62Asp) was located within a highly conserved region of the STXBP2 protein and predicted to be deleterious. PMID: 26451869
    7. mutations result in severe chronic active Epstein-Barr virus disease PMID: 25947952
    8. red blood cells express Munc18-2 and that erythroid cells from patients with FHL-5 exhibit intrinsic defects caused by STXBP2/Munc18-2 mutations. PMID: 26320718
    9. Munc18-2(R65Q) and Munc18-2(R65W) retain the ability to interact with and stabilize STX11. However, presence of Munc18-2(R65Q/W) in patient-derived lymphocytes and forced expression in control CTLs and NK cells diminishes degranulation and cytotoxicity. PMID: 25564401
    10. Data show that all but one patient with atypical familial hemophagocytic lymphohistiocytosis carried at least one splice-site mutation in UNC13D or STXBP2. PMID: 20823128
    11. Munc18-2 binds the N-terminal peptide of Stx11 with a ~20-fold higher affinity than Stx3, suggesting a potential role in selective binding. PMID: 24194549
    12. We report that FHL-5 neutrophils have a profound defect in granule mobilization, resulting in inadequate bacterial killing, in particular, of gram-negative Escherichia coli, but not of Staphylococcus aureus. PMID: 23687090
    13. Mutations in STXBP2 do not only affect cytotoxic T lymphocytes but also cause changes in the intestinal and renal epithelium resulting in severe, osmotic diarrhea and renal proximal tubular dysfunction PMID: 23382066
    14. Novel mutation in STXBP2 prevents IL-2-induced natural killer cell cytotoxicity in familial hemophagocytic lymphohistiocytosis. PMID: 22336081
    15. We report the largest cohort of patients with FHL5 so far, describe an extended disease spectrum, and demonstrate for the first time a clear genotype-phenotype correlation. PMID: 22451424
    16. Missense and splice-site sequence variants in PRF1, MUNC13-4, and STXBP2 were found in 25 (14%) of the adult patients. The A91V-PRF1 genotype was found in 12 of these patients (48%). PMID: 21881043
    17. Data show that 3 novel mutations of STXBP2 gene were confirmed. PMID: 21152410
    18. Biallelic STXBP2 mutations were identified in families with familial haemophagocytic lymphohistiocytosis. PMID: 20798128
    19. mutation analysis, clinical presentation, and functional analysis of NK cells in patients with mutations in STXBP2 encoding Munc18-2, recently associated with familial hemophagocytic lymphohistiocytosis type 5 PMID: 20558610
    20. STXBP2 is required at a late step of the secretory pathway for the release of cytotoxic granules by binding syntaxin 11, another component of the intracellular membrane fusion machinery. PMID: 19884660
    21. binds to syntaxins 1A, 2, and 3 and regulates vesicle transport to the apical plasma membrane PMID: 12198139
    22. Munc18-2 acts as a regulator of primary granule exocytosis, while Munc18-3 may preferentially regulate the fusion of secondary granules PMID: 18588921
    23. Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is caused by mutations in Munc18-2 and impaired binding to syntaxin 11 PMID: 19804848

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    Familial hemophagocytic lymphohistiocytosis 5 (FHL5)
  • 蛋白家族：
    STXBP/unc-18/SEC1 family
  • 組織特異性：
    Placenta, lung, liver, kidney and pancreas, as well as in peripheral blood lymphocytes.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11445

    OMIM: 601717

    KEGG: hsa:6813

    STRING: 9606.ENSP00000221283

    UniGene: Hs.515104



主站蜘蛛池模板： 亚洲性色成人av| 呦男呦女视频精品八区| 国产成人mv视频在线观看| 国语少妇高潮对白在线| 青青草视频在线观看| 蜜桃视频网站| 久久综合九色综合欧美婷婷| 亚洲精品国产自在现线最新| 国产欧美亚洲精品a| 亚洲va欧美va天堂v国产综合| 国产成人 综合 亚洲欧洲| 无码三级中文字幕在线观看| 国产伦久视频免费观看视频| 欧美成人午夜免费全部完| 欧美性色黄大片www喷水| 日日碰狠狠躁久久躁9| 国产成人精品一区二三区| 怡红院免费的全部视频| 2021最新精品国自产拍视频| 欧美另类精品xxxx人妖| 久久人人爽av亚洲精品天堂| 人妻丝袜av中文系列先锋影音| 久久露脸国产精品| 午夜一区一品日本| 中文在线√天堂| 欧洲亚洲1卡二卡三卡2021| 无码大潮喷水在线观看| 亚洲人成影院在线观看| 亚洲无线观看国产精品| 久久www成人片免费看| 曰本av中文字幕一区二区| 女人的精水喷出来视频| 全部露出来毛走秀福利视频| 亚洲乱妇亚洲乱妇xinglu| 久久精品国产亚洲精品| 久久精品熟女亚州av麻豆| 国产福利在线永久视频| 99久热在线精品996热是什么| 亚洲综合激情另类小说区 | 日本三级吃奶头添泬| 男女裸交无遮挡啪啪激情试看|