Recombinant Human Storkhead-box protein 1 (STOX1), partial

中文名稱：

人STOX1重組蛋白
貨號：

CSB-YP765089HU
規(guī)格：
來源：

Yeast
其他：

中文名稱：

人STOX1重組蛋白
貨號：

CSB-EP765089HU
規(guī)格：
來源：

E.coli
其他：

中文名稱：

人STOX1重組蛋白
貨號：

CSB-EP765089HU-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人STOX1重組蛋白
貨號：

CSB-BP765089HU
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人STOX1重組蛋白
貨號：

CSB-MP765089HU
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

STOX1
Uniprot No.：

Q6ZVD7
別名：

STOX1; C10orf24; Storkhead-box protein 1; Winged-helix domain-containing protein
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta. Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway.; Involved in cell cycle regulation by binding to the CCNB1 promoter, up-regulating its expression and promoting mitotic entry. Induces phosphorylation of MAPT/tau.
基因功能參考文獻：
1. The STOX1 mice could help to better understand the endothelial dysfunction in the context of preeclampsia, and guide the search for efficient therapies able to protect the maternal endothelium during the disease and its aftermath. PMID: 26758611
2. Transcription factor STOX1A and its target gene, CNTNAP2, are potentially involved in the etiology of Alzheimer's disease. PMID: 22728895
3. STOX1 is one of the genes that give susceptibility for preeclampsia. PMID: 21490791
4. A STOX1A-dependent effect on tau phosphorylation found in neurodegenerative diseases such as Alzheimer's disease. PMID: 22995177
5. Mitotic entry is enhanced through the direct upregulation of cyclin B1 expression effectuated by STOX1A. PMID: 22253775
6. Upregulation of total tau expression (SFRS7-independent) and tau exon 10 splicing (SFRS7-dependent), as shown in this study to be both affected by STOX1A, is known to have implications in neurodegeneration. PMID: 21755018
7. STOX1 does not show differential expression in deciduas from pregnancies complicated by both pre-eclampsia and FGR as compared with controls. PMID: 20643876
8. methylation is independent of parental origin, but regulates STOX1 expression with the Y153H genotype directing the level of methylation. PMID: 20716964
9. The risk allele (Y153H) of the preeclampsia susceptibility gene STOX1 negatively regulates trophoblast invasion by upregulation of the cell-cell adhesion protein a-T-catenin (CTNNA3). PMID: 20400461
10. role in placental development and preeclampsia (Review) PMID: 19577309
11. The data of this study indicated that STOX1 controls a conserved pathway shared between placenta and brain with overexpression in late-onset Alzheimer's disease. PMID: 20110611
12. In conclusion, we are unable to validate STOX1 as a common preeclampsia susceptibility gene. PMID: 17290274
13. Anomalies in STOX1 expression are associated with the onset of preeclampsia. PMID: 19079545
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相關(guān)疾病：

Pre-eclampsia/eclampsia 4 (PEE4)
亞細胞定位：

[Isoform A]: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.; [Isoform B]: Nucleus.; [Isoform C]: Nucleus, nucleolus.
組織特異性：

Expressed in placenta, including the invasive extravillus trophoblast cells.
數(shù)據(jù)庫鏈接：

HGNC: 23508

OMIM: 609397

KEGG: hsa:219736

STRING: 9606.ENSP00000298596

UniGene: Hs.37636