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  4. STOX1 Antibody, Biotin conjugated

STOX1 Antibody, Biotin conjugated

  • 中文名稱：
    STOX1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA765089LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) STOX1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    STOX1
  • 別名：
    STOX1 antibody; C10orf24 antibody; Storkhead-box protein 1 antibody; Winged-helix domain-containing protein antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Storkhead-box protein 1 protein (559-858AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta. Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway.; Involved in cell cycle regulation by binding to the CCNB1 promoter, up-regulating its expression and promoting mitotic entry. Induces phosphorylation of MAPT/tau.
  • 基因功能參考文獻(xiàn)：
    1. The STOX1 mice could help to better understand the endothelial dysfunction in the context of preeclampsia, and guide the search for efficient therapies able to protect the maternal endothelium during the disease and its aftermath. PMID: 26758611
    2. Transcription factor STOX1A and its target gene, CNTNAP2, are potentially involved in the etiology of Alzheimer's disease. PMID: 22728895
    3. STOX1 is one of the genes that give susceptibility for preeclampsia. PMID: 21490791
    4. A STOX1A-dependent effect on tau phosphorylation found in neurodegenerative diseases such as Alzheimer's disease. PMID: 22995177
    5. Mitotic entry is enhanced through the direct upregulation of cyclin B1 expression effectuated by STOX1A. PMID: 22253775
    6. Upregulation of total tau expression (SFRS7-independent) and tau exon 10 splicing (SFRS7-dependent), as shown in this study to be both affected by STOX1A, is known to have implications in neurodegeneration. PMID: 21755018
    7. STOX1 does not show differential expression in deciduas from pregnancies complicated by both pre-eclampsia and FGR as compared with controls. PMID: 20643876
    8. methylation is independent of parental origin, but regulates STOX1 expression with the Y153H genotype directing the level of methylation. PMID: 20716964
    9. The risk allele (Y153H) of the preeclampsia susceptibility gene STOX1 negatively regulates trophoblast invasion by upregulation of the cell-cell adhesion protein a-T-catenin (CTNNA3). PMID: 20400461
    10. role in placental development and preeclampsia (Review) PMID: 19577309
    11. The data of this study indicated that STOX1 controls a conserved pathway shared between placenta and brain with overexpression in late-onset Alzheimer's disease. PMID: 20110611
    12. In conclusion, we are unable to validate STOX1 as a common preeclampsia susceptibility gene. PMID: 17290274
    13. Anomalies in STOX1 expression are associated with the onset of preeclampsia. PMID: 19079545

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  • 相關(guān)疾病：
    Pre-eclampsia/eclampsia 4 (PEE4)
  • 亞細(xì)胞定位：
    [Isoform A]: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.; [Isoform B]: Nucleus.; [Isoform C]: Nucleus, nucleolus.
  • 組織特異性：
    Expressed in placenta, including the invasive extravillus trophoblast cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 23508

    OMIM: 609397

    KEGG: hsa:219736

    STRING: 9606.ENSP00000298596

    UniGene: Hs.37636



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