在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Sterol regulatory element-binding protein 2 (SREBF2), partial

Recombinant Human Sterol regulatory element-binding protein 2 (SREBF2), partial

  • 中文名稱：
    人SREBF2重組蛋白
  • 貨號：
    CSB-YP621515HU1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SREBF2重組蛋白
  • 貨號：
    CSB-EP621515HU1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SREBF2重組蛋白
  • 貨號：
    CSB-EP621515HU1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SREBF2重組蛋白
  • 貨號：
    CSB-BP621515HU1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SREBF2重組蛋白
  • 貨號：
    CSB-MP621515HU1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    SREBF2; BHLHD2; SREBP2; Sterol regulatory element-binding protein 2; SREBP-2; Class D basic helix-loop-helix protein 2; bHLHd2; Sterol regulatory element-binding transcription factor 2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane. Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis.; Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Regulates transcription of genes related to cholesterol synthesis pathway.
  • 基因功能參考文獻：
    1. SREBF2 polymorphism rs2269657 showed significant dual associations with LOAD pathological biomarkers and gene expression levels. Furthermore, SREBF2 expression levels measured in LOAD frontal cortices inversely correlated with age at death; suggesting a possible influence on survival rate. PMID: 29503034
    2. SREBP-2 regulates autophagy-related gene expression in human liver cells. PMID: 29336468
    3. High SREBP-2 expression is associated with hypercholesterolemia. PMID: 29678744
    4. By altering the membrane trafficking through the lysosomes, cholesterol redistributes and regulates SREBP-2. PMID: 28696297
    5. The gene polymorphism of SREBP2 not only significantly associated with the clinical phenotypes of osteonecrosis of the femoral head but also closely related to lipid metabolism disorder. PMID: 28901487
    6. The current investigation indicated that the rs2267439C/T polymorphism in the SREBF-2 gene increased the T2D susceptibility in an Iranian population. PMID: 29601949
    7. Hexacosanol activates AMPK and hepatic autophagy and inhibits SREBP2, resulting in hypocholesterolemic activities and improvement of hepatic steatosis. PMID: 28676202
    8. CpG sites located in SREBF2 gene showed differential methylation in association with total cholesterol. The expression of the SREBF2 was inversely associated with methylation of its corresponding CpGs. PMID: 28173150
    9. Acidic pH-responsive SREBP2 target genes were associated with reduced overall survival of cancer patients. PMID: 28249167
    10. these clinical and experimental results reveal a novel role of SREBP-2 in the induction of a stem cell-like phenotype and prostate cancer metastasis PMID: 26883200
    11. These results seem to suggest an involvement of SREBF-2 in the integrity of white matter tracts in bipolar disorder and therefore a possible role of SREBP pathway in CNS myelination processes. PMID: 27771555
    12. High expression of SREBF2 is associated with high carotid intima-media thickness. PMID: 27841945
    13. mechanistic investigation provides clinical insights into protective roles of the epithelial cholesterol deficiency against excessive inflammatory responses via the SREBP2-HuR circuit, although the deficiency triggers transient pro-inflammatory signals. PMID: 27703009
    14. Dietary flavones counteract phorbol 12-myristate 13-acetate-induced SREBP-2 processing in hepatic cells. PMID: 27778136
    15. Identify a novel signaling pathway in hepatocytes triggered by ligand-activated p75NTR that via p38 MAPK and caspase-3 mediate the activation of SREBP2. This pathway may regulate LDLRs and lipid uptake particularly after injury or during tissue inflammation accompanied by an increased production of growth factors, including NGF and pro-NGF. PMID: 26984409
    16. The connections of EGFR and ERBB4 signaling with SREBP-2-regulated cholesterol metabolism are likely to be important in ERBB-regulated developmental processes and may contribute to metabolic remodeling in ERBB-driven cancers. PMID: 26535009
    17. knockdown of endogenous SREBP2 in HepG2 cells lowered ACSL1 mRNA and protein levels. PMID: 26728456
    18. Data suggest lysophosphatidylcholine (LPC) up-regulates SREBP-2 and cholesterol efflux in vascular endothelium; 25-hydroxycholesterol (25-HC) inhibits these effects of LPC; both LPC and 25-HC up-regulate release of interleukin-6 and interleukin-8. PMID: 25998247
    19. the results of the present study showed that luteolin modulates HMGCR transcription by decreasing the expression and nuclear translocation of SREBP-2. PMID: 26302339
    20. HCV core protein disturbs the cholesterol homeostasis in HepG2 cells via the SREBP2 pathway; miR-185-5p is involved in the regulation of SREBP2 by the core protein. PMID: 25914460
    21. the 5-aminoimidazole-4-carboxyamide ribonucleoside (AICAR)-induced activation of AMPK directly inhibited the expression of SREBP-2 and HMGCR and HMGCS, and suppressed the TSH-stimulated up-regulation of SREBP-2 in HepG2 cells. PMID: 25933205
    22. Suggest important role for SREBP-2 in regulation of lipid and glucose metabolism in hypertensive rats. PMID: 24908080
    23. Our results show that though leptin stimulates LDLR expression very weakly through JAK-STAT signaling pathway, it mainly imposes inhibition on LDLR expression by inhibiting transcription factor SREBP2 PMID: 25488447
    24. The results of this study suggested that the genetic polymorphisms of SREBF2 gene may be associated with metabolic syndrome in patients treated with clozapine. PMID: 25201120
    25. SREBP-2 rs2228314 G to C change and variant C genotype as well as LXRalpha rs11039155 G to A change and variant A may contribute to PCOS in Chinese Han population PMID: 25005769
    26. The SREBP-induced NOD-like receptor family pyrin domain-containing protein inflammasome and its instigation of innate immunity is an important contributor to atherosclerosis. PMID: 25188917
    27. The results of this study provide evidence that the GG genotype and G carrier (CG+GG) of rs2228314 G>C polymorphism in the SREBP-2 gene may increase the risk of NAFLD. PMID: 24992162
    28. findings suggest that SREBP2-miR-92a-inflammasome exacerbates endothelial dysfunction during oxidative stress PMID: 25550450
    29. SREBP-2 rs2228314 G to C change and variant C genotype may contribute to knee osteoarthritis risk in a Chinese Han population. PMID: 24496149
    30. Data show that forkhead transcription factor 4 (FoxO4) interacts with sterol regulatory element binding protein (SREBP)2 and hypoxia inducible factor (HIF)2alpha to modulate lanosterol 14alpha demethylase (CYP51) promoter activity. PMID: 24353279
    31. Rating SREBF2 polymorphism did not reveal a relationship to the occurrence of ischemic heart disease in patients with obstructive sleep apnea, both in the whole group as well as separate subgroups. PMID: 24868893
    32. A single nucleotide polymorphism that tags both the XRCC6 and SREBF2 genes strongly modifies the association between bladder cancer risk and smoking PMID: 24382701
    33. SREBP cleavage regulates Golgi-to-endoplasmic reticulum recycling of SREBP cleavage-activating protein (SCAP) PMID: 24478315
    34. These results suggest that SREBP-2 negatively regulates the FXR-mediated transcriptional activation of the FGF19 gene in human intestinal cells. PMID: 24321096
    35. Results suggested that interaction of SREBP-2 gene polymorphisms and the relationship between the polymorphisms and clinical phenotype of IGFBP-3 were closely related to increased ANFH risk in the Chinese population. PMID: 23158139
    36. Atheroprone flow induces NLRP3 inflammasome in endothelium through SREBP2 activation. PMID: 23838163
    37. Data indicate that SREBP-2 and Scap are regulated by factors driving prostate growth, and suggest exploring this observation further could shed light on prostate carcinogenesis. PMID: 23454642
    38. Starvation regulates endothelial lipase expression via SREBP-2. PMID: 23102786
    39. RNAi-mediated inhibition of SREBP2 expression significantly ameliorated the cholesterol accumulation induced by inflammatory cytokines in HepG2 cells. PMID: 23044239
    40. Results demonstrated, for the first time, the association of SREBP-2 with osteoarthritis pathogenesis and provided evidence on the molecular mechanism involved. PMID: 22662110
    41. Endoplasmic reticulum stress-induced SREBP-2 activation contributes to renal proximal tubule cell injury by dysregulating lipid homeostasis. PMID: 22573382
    42. SREBP-2 is directly linked as a target of amyloid-beta protein in cholesterol homeostasis impairment. PMID: 22573671
    43. SREBP-2 1784 G/C polymorphism is associated with non-alcoholic fatty liver disease in Asian Indians in north India. PMID: 22182810
    44. Linalool reduces the expression of 3-hydroxy-3-methylglutaryl CoA reductase via sterol regulatory element binding protein-2- and ubiquitin-dependent mechanisms. PMID: 21944868
    45. A combination oral contraceptive maintained a high-profile expression of LDLR through the stimulation of its transcription factor SREBP2 in primary placental trophoblasts and Jar cell line. PMID: 21757058
    46. could not identify any association between SREBF-2 1784G > C or SCAP 2386A > G SNPs and premature coronary artery disease or extent of coronary lesions in a Chinese population. PMID: 20111910
    47. results demonstrate for the first time that HIV-1 transcription in T cells is linked to cholesterol homeostasis through control of TFII-I expression by SREBP2 PMID: 21613400
    48. hepatic NPC1L1 in the liver from Chinese female gallstone patients may be mediated by SREBP2 PMID: 20144195
    49. miR-33 expression from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation PMID: 20732877
    50. Data show that miR-33 is encoded within SREBP-2 and that both mRNAs are coexpressed. PMID: 20566875

    顯示更多

    收起更多

  • 亞細胞定位：
    [Sterol regulatory element-binding protein 2]: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein.; [Processed sterol regulatory element-binding protein 2]: Nucleus.
  • 蛋白家族：
    SREBP family
  • 組織特異性：
    Ubiquitously expressed in adult and fetal tissues.
  • 數據庫鏈接：

    HGNC: 11290

    OMIM: 600481

    KEGG: hsa:6721

    STRING: 9606.ENSP00000354476

    UniGene: Hs.443258



主站蜘蛛池模板： 2020精品国产自在现线官网| 激情内射人妻1区2区3区 | 高清偷自拍第1页| 国产后进白嫩翘臀在线播放| 青青草国产精品欧美成人| 青青草国产精品久久久久| 中文字幕中文乱码www| 色婷婷综合久色aⅴ五区最新| 精品夜夜爽欧美毛片视频| 久久婷婷五月综合色精品| 无码专区—va亚洲v天堂麻豆| 国产三级视频在线播放线观看| 在线看片福利无码网址| 亚洲午夜国产精品无码老牛影视| 久久人人爽人人爽人人av东京热 | 最新精品国偷自产在线| 久久99精品国产自在现线小黄鸭| 亚洲kkk4444在线观看 | 久久久久久久久无码精品亚洲日韩 | 久久久久国产精品无码免费看| 狠狠色噜噜狠狠狠777米奇小说 | av无码av在线a∨天堂app| 欧美性猛交久久久乱大交小说| 亚洲成在人线视av| 亚洲日韩av片在线观看| 亚洲妇女自偷自偷图片| 欧美人与动牲猛交a欧美精品| 全黄激性性视频| 国产成人8x人网站视频| 久久精品日韩av无码| 亚洲欧美另类久久久精品| а√天堂资源中文在线官网| 国产高清japanese在线播放e| 久久精品成人免费国产片小草 | 国产精品扒开腿做爽爽爽a片唱戏| 国产午夜成人免费看片| 久久视频这里只精品| 欧美伊人色综合久久天天| 国产精品老热丝在线观看| 国内大量揄拍人妻精品視頻| 女狠狠噜天天噜日日噜|