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Recombinant Human Stereocilin (STRC), partial

  • 中文名稱:
    人STRC重組蛋白
  • 貨號:
    CSB-YP022878HU
  • 說明書:
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人STRC重組蛋白
  • 貨號:
    CSB-EP022878HU
  • 說明書:
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人STRC重組蛋白
  • 貨號:
    CSB-EP022878HU-B
  • 說明書:
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人STRC重組蛋白
  • 貨號:
    CSB-BP022878HU
  • 說明書:
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人STRC重組蛋白
  • 貨號:
    CSB-MP022878HU
  • 說明書:
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    STRC
  • Uniprot No.:
  • 別名:
    DFNB16; Stereocilin; STRC; STRC_HUMAN
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Essential to the formation of horizontal top connectors between outer hair cell stereocilia.
  • 基因功能參考文獻:
    1. results provide strong evidence that STRC gene mutations are an important cause of nonsyndromic hearing loss-autosomal recessive in Czech hearing loss patients. PMID: 29425068
    2. STRC was the second most frequently mutated gene in patients from the Czech Republic with hearing loss PMID: 28984810
    3. Three probands with progressive mild to moderate hearing loss were found among 40 subjects with autosomal recessive non-syndromic hearing loss to segregate homozygous STRC deletions and gene to pseudogene conversion. PMID: 27469136
    4. we hypothesized that the p.Q1353X variation in the STRC gene is the causative mutation for hearing loss. PMID: 26746617
    5. STRC is a major contributor to DFNB16 congenital hearing impairment. PMID: 26011646
    6. The data suggest that STRC may be a common contributor to NBSNHI among GJB2 mutation negative probands, especially in those with mild to moderate hearing impairment. PMID: 22147502

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  • 相關疾病:
    Deafness, autosomal recessive, 16 (DFNB16); Deafness-infertility syndrome (DIS)
  • 亞細胞定位:
    Cell surface. Cell projection, kinocilium. Cell projection, stereocilium.
  • 蛋白家族:
    Stereocilin family
  • 數據庫鏈接:

    HGNC: 16035

    OMIM: 603720

    KEGG: hsa:161497

    STRING: 9606.ENSP00000401513

    UniGene: Hs.657395



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