在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Sphingomyelin phosphodiesterase 2 (SMPD2), partial

  • 中文名稱:
    人SMPD2重組蛋白
  • 貨號:
    CSB-YP021846HU1
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人SMPD2重組蛋白
  • 貨號:
    CSB-EP021846HU1
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人SMPD2重組蛋白
  • 貨號:
    CSB-EP021846HU1-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人SMPD2重組蛋白
  • 貨號:
    CSB-BP021846HU1
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人SMPD2重組蛋白
  • 貨號:
    CSB-MP021846HU1
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    SMPD2
  • Uniprot No.:
  • 別名:
    SMPD2; Sphingomyelin phosphodiesterase 2; Lyso-platelet-activating factor-phospholipase C; Lyso-PAF-PLC; Neutral sphingomyelinase; N-SMase; nSMase; nSMase1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Hydrolyze 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor).
  • 基因功能參考文獻:
    1. Interestingly, neutral but not acid sphingomyelinase was mandatory for PorBIA -mediated Neisseria gonorrhoeae invasion into host cells. PMID: 25224994
    2. nSMase1 (sphingomyelin phosphodiesterase 2, SMPD2)has a common central role in ceramide signaling during the stress and cytokine responses and apoptosis. PMID: 25168245
    3. These data suggest that Ox-LDL activates N-SMase-ceramide signaling pathway, and stimulates phosphorylation of p38 MAPK, leading to apoptosis in vascular smooth muscle cells, which initiates VSMC calcification. PMID: 24358176
    4. NSM2 plays a key role in the cellular response to hyperosmolar stress, and its activity regulates both cytokine secretion and lipid droplet formation. PMID: 22899568
    5. nSMase2 has a role in ceramide generation, aberrant apoptosis, and lung injury under cigarette smoke exposure PMID: 20448054
    6. N-SMase at the cytofacial plasma membrane is an essential element for the proper orientation of PMNs in FMLP gradients, at least in part by polarizing the distribution of Rac 1/2 and RhoA GTPases. PMID: 20378749
    7. Results demonstrate that WithaD enhance the ceramide accumulation by activating N-SMase 2, modulate phosphorylation of the JNK and p38MAPK and induced apoptosis in both myeloid and lymphoid cells along with primary cells derived from leukemia patients. PMID: 20836852
    8. Data show DA remarkably increased the NSMase2 message and protein, whereas little change in NSMase1 and NSMase3 mRNAs. PMID: 19698806
    9. nSMase2 functions as a growth suppressor in MCF7 cells, linking confluence to the G(0)/G(1) cell cycle check point. PMID: 15051724
    10. identification of 15 polymorphisms, including 9 novel SNPs, in the SMPD2 gene; one haplotype showed associations with the extrinsic type of atopic dermatitis subgroup PMID: 17212982
    11. The catalytic region of neutral sphingomyelinase 2 where palmitoylation occurs is found to be localized at the inner leaflet of the plasma membrane. PMID: 17272284
    12. This study underlines the importance of neutral sphingomyelinase-ceramide pathway in mediating oxidative stress-induced apoptosis and cell death of human primary oligodendrocytes. PMID: 18040843

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Neutral sphingomyelinase family
  • 數據庫鏈接:

    HGNC: 11121

    OMIM: 603498

    KEGG: hsa:6610

    STRING: 9606.ENSP00000258052

    UniGene: Hs.55235



主站蜘蛛池模板: 国产精品人妻久久毛片| 免费网站看v片在线18禁无码| 日本熟妇hdsex视频| 欧美性猛少妇xxxxx免费| 日韩精品一卡2卡3卡4卡新区视频| 热99re久久精品这里都是精品免费 | 激情综合婷婷丁香五月| 在厨房拨开内裤进入毛片| 久久婷婷五月综合色国产香蕉| 亚洲国产成人久久综合人| 在线观看的av免费网站| a毛片终身免费观看网站| 亚洲欧美在线观看| 狂野欧美性猛交免费视频| 人人鲁人人莫人人爱精品| 国产精品亚洲二区在线播放| 日本少妇xxxx做受| 精品熟女少妇av免费久久| 久久国产劲爆∧v内射| 国产福利在线视频蜜芽tv| 亚洲综合无码一区二区三区不卡| 大胆日本熟妇xxxx| 亚洲成a人v欧美综合天堂麻豆| 极品熟妇大蝴蝶20p| 麻豆精品一卡二卡三卡| 国产未成女一区二区| 国产精品视频在线观看| 波多野结衣av无码久久一区| 校园春色~综合网| 亚洲高清无码加勒比| 在线精品视频一区二区三四| 欧美性猛交久久久乱大交小说| 国产色视频一区二区三区| 日韩精品一卡2卡三卡4卡| 久拍国产在线观看| 最近最新中文字幕高清免费| 中文字幕人成乱码在线观看| 特级无码毛片免费视频播放▽| 日产精品卡1卡2卡三卡在线| 在线看免费无码av天堂的| 亚洲多毛妓女毛茸茸的|