在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SMPD2 Antibody, Biotin conjugated

  • 中文名稱:
    SMPD2兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA021846LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) SMPD2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SMPD2
  • 別名:
    SMPD2; Sphingomyelin phosphodiesterase 2; Lyso-platelet-activating factor-phospholipase C; Lyso-PAF-PLC; Neutral sphingomyelinase; N-SMase; nSMase; nSMase1
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Sphingomyelin phosphodiesterase 2 protein (199-301AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Hydrolyze 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor).
  • 基因功能參考文獻(xiàn):
    1. Interestingly, neutral but not acid sphingomyelinase was mandatory for PorBIA -mediated Neisseria gonorrhoeae invasion into host cells. PMID: 25224994
    2. nSMase1 (sphingomyelin phosphodiesterase 2, SMPD2)has a common central role in ceramide signaling during the stress and cytokine responses and apoptosis. PMID: 25168245
    3. These data suggest that Ox-LDL activates N-SMase-ceramide signaling pathway, and stimulates phosphorylation of p38 MAPK, leading to apoptosis in vascular smooth muscle cells, which initiates VSMC calcification. PMID: 24358176
    4. NSM2 plays a key role in the cellular response to hyperosmolar stress, and its activity regulates both cytokine secretion and lipid droplet formation. PMID: 22899568
    5. nSMase2 has a role in ceramide generation, aberrant apoptosis, and lung injury under cigarette smoke exposure PMID: 20448054
    6. N-SMase at the cytofacial plasma membrane is an essential element for the proper orientation of PMNs in FMLP gradients, at least in part by polarizing the distribution of Rac 1/2 and RhoA GTPases. PMID: 20378749
    7. Results demonstrate that WithaD enhance the ceramide accumulation by activating N-SMase 2, modulate phosphorylation of the JNK and p38MAPK and induced apoptosis in both myeloid and lymphoid cells along with primary cells derived from leukemia patients. PMID: 20836852
    8. Data show DA remarkably increased the NSMase2 message and protein, whereas little change in NSMase1 and NSMase3 mRNAs. PMID: 19698806
    9. nSMase2 functions as a growth suppressor in MCF7 cells, linking confluence to the G(0)/G(1) cell cycle check point. PMID: 15051724
    10. identification of 15 polymorphisms, including 9 novel SNPs, in the SMPD2 gene; one haplotype showed associations with the extrinsic type of atopic dermatitis subgroup PMID: 17212982
    11. The catalytic region of neutral sphingomyelinase 2 where palmitoylation occurs is found to be localized at the inner leaflet of the plasma membrane. PMID: 17272284
    12. This study underlines the importance of neutral sphingomyelinase-ceramide pathway in mediating oxidative stress-induced apoptosis and cell death of human primary oligodendrocytes. PMID: 18040843

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Neutral sphingomyelinase family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 11121

    OMIM: 603498

    KEGG: hsa:6610

    STRING: 9606.ENSP00000258052

    UniGene: Hs.55235



主站蜘蛛池模板: 欧美人与动人物牲交免费观看| 大肉大捧一进一出视频| 欧美成年视频在线观看| 欧美熟妇性开放| 欧美亚洲日韩国产综合电影| 亚洲aⅴ天堂av天堂无码app| 国产剧情无码播放在线看| 国产成人精品视频ⅴa片软件竹菊| 日本乱人伦在线观看| 怡春院国产精品视频| 欧美亚洲另类 丝袜综合网| 2022一本久道久久综合狂躁| 成人艳情一二三区| 影音先锋男人站| 日韩成人无码v清免费| 97se色综合一区二区二区| 国产精品特级露脸av毛片| 99er国产这里只有精品视频免费| 中文字幕av伊人av无码av狼人 | 蜜桃av无码免费看永久| 乱码精品一区二区三区| 毛片内射久久久一区| 国产精品视频白浆免费视频| 国产精品国产三级国av| 久久综合给合久久97色| 中文字幕亚洲无线码在线一区| 无码专区 人妻系列 在线| 国产福利无码一区在线| 欧美一区二区三区红桃小说| 无码专区男人本色| 国产在线看片免费视频| 国产99视频精品免费视看6| 久久久久成人精品免费播放动漫 | 久久这里有精品国产电影网| 激情内射日本一区二区三区| 国产寡妇偷人在线观看| 亚洲国产成人在人网站天堂| 亚洲国产av一区二区三区| 国产av人人夜夜澡人人爽| 中国凸偷窥xxxx自由视频| 精品久久无码中文字幕 |