在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Speckle targeted PIP5K1A-regulated poly (A) polymerase (TUT1), partial

Recombinant Human Speckle targeted PIP5K1A-regulated poly (A) polymerase (TUT1), partial

  • 中文名稱：
    人TUT1重組蛋白
  • 貨號：
    CSB-YP884477HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人TUT1重組蛋白
  • 貨號：
    CSB-EP884477HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人TUT1重組蛋白
  • 貨號：
    CSB-EP884477HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人TUT1重組蛋白
  • 貨號：
    CSB-BP884477HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人TUT1重組蛋白
  • 貨號：
    CSB-MP884477HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    TUT1
  • Uniprot No.：
  • 別名：
    alpha regulated poly(A) polymerase ; nuclear speckle targeted phosphatidylinositol 4 phosphate 5 kinase type I; nuclear speckle targeted PIPK1A regulated poly(A) polymerase ; PAP associated domain containing 2 ; PAPD2; poly(A) polymerase associated domain containing 2 ; RBM21; RNA binding motif protein 21 ; RNA-binding motif protein 21; RNA-binding protein 21; Speckle targeted PIP5K1A-regulated poly(A) polymerase; Star-PAP; STARPAP; STPAP_HUMAN; terminal uridylyl transferase 1; U6 snRNA specific ; TUT1; TUTase; U6 snRNA specific terminal uridylyltransferase 1; U6 snRNA-specific terminal uridylyltransferase 1; U6 TUTase; U6-TUTase; URLC6
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication-dependent histone mRNA degradation.
  • 基因功能參考文獻：
    1. Crystallographic and biochemical studies of TUT1 revealed the molecular mechanism underlying the specific oligo-uridylylation of the 3'-end of U6 snRNA by TUT1. PMID: 28589955
    2. Star-PAP possesses tumor-suppressing activity. PMID: 28151486
    3. Star-PAP-specific polyadenylation sites usage regulates the expression of the eukaryotic translation initiation factor EIF4A1, the tumor suppressor gene PTEN and the long non-coding RNA NEAT1. PMID: 28911096
    4. Star-PAP recognises a unique nucleotide motif on its target mRNA.CstF-64 and 3'-UTR cis-element determine Star-PAP specificity for target mRNA selection by excluding poly A polymerase. PMID: 26496945
    5. Nucleotidyl transferase TUT1 inhibits lipogenesis in osteosarcoma cells through regulation of microRNA-24 and microRNA-29a. PMID: 25142229
    6. Star-PAP controls E6 mRNA polyadenylation and expression and modulates wild-type p53 levels. PMID: 23416977
    7. The human TUT1 nucleotidyl transferase is a global regulator of microRNA abundance. PMID: 23874977
    8. Star-PAP and its regulatory molecules form a signaling nexus at the 3'-end of target mRNAs to control the expression of select group of genes including the ones involved in stress responses. (Review) PMID: 23306079
    9. PIPKIalpha, PI4,5P(2), and PKCdelta regulate Star-PAP control of BIK expression and induction of apoptosis. PMID: 22244330
    10. The data support a model where Star-PAP binds to the pre-mRNA, recruits the CPSF complex to the 3'-end of pre-mRNA and then defines cleavage by CPSF 73 and subsequent polyadenylation of its target mRNAs. PMID: 21102410
    11. PIPKIalpha co-localizes at nuclear speckles and interacts with a newly identified non-canonical poly(A) polymerase, Star-PAP; the activity of Star-PAP can be specifically regulated by PtdIns4,5P2 PMID: 18288197
    12. These data indicate that CKIalpha, PIPKIalpha, and Star-PAP function together to modulate the production of specific Star-PAP messages. PMID: 18305108

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus, nucleolus. Nucleus speckle.
  • 蛋白家族：
    DNA polymerase type-B-like family
  • 組織特異性：
    Widely expressed.
  • 數據庫鏈接：

    HGNC: 26184

    OMIM: 610641

    KEGG: hsa:64852

    STRING: 9606.ENSP00000308000

    UniGene: Hs.728983



主站蜘蛛池模板： 国产情侣草莓视频在线| 美女视频黄是免费| 欧美艳星nikki激情办公室| 亚洲精品久久一区二区三区四区| 亚洲 欧美精品suv| 亚洲a无码综合a国产av中文| 国产女主播白浆在线观看| 国产精品一区二区av蜜芽| 国产午夜高清高清在线观看| 亚洲毛片αv无线播放一区| 好男人社区资源| 成 人 色综合 综合网站| 欧美性大战xxxxx久久久√| 亚洲国产精品成人久久蜜臀| 精品国产不卡一区二区三区 | 男女裸交免费无遮挡全过程| 日产日韩亚洲欧美综合下载| 亚洲精品久久av无码麻| 国产农村老太xxxxhdxx| 黄瓜视频在线观看| 亚洲a综合一区二区三区| 亚洲乱码伦小说区| 99久久免费精品高清特色大片 | 精品少妇人妻av一区二区三区 | 亚州少妇无套内射激情视频| 欧美精品九九久久久久久久久 | 思思99热久久精品在线6| 99视频偷窥在线精品国自产拍| 国产亚洲精品久久久久小| 日本免费人成在线观看网站| 天天综合网天天综合色| av人摸人人人澡人人超碰小说| 欧美亚洲色aⅴ大片| 少妇又色又紧又爽又刺激视频| 亚洲人成色7777在线观看| 伊人精品一本久久综合| 精品国产高清毛片a片看| 久久精品国产色蜜蜜麻豆| 国产成人综合色视频精品| 国产色情又大又粗又黄的电影| 中文字幕无码乱人伦|