在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. TUT1 Antibody

TUT1 Antibody

  • 中文名稱：
    TUT1兔多克隆抗體
  • 貨號：
    CSB-PA046708
  • 規格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from 3T3 cells, using TUT1 antiobdy.
    • Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using TUT1 antibody.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) TUT1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TUT1
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human TUT1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication-dependent histone mRNA degradation.
  • 基因功能參考文獻：
    1. Crystallographic and biochemical studies of TUT1 revealed the molecular mechanism underlying the specific oligo-uridylylation of the 3'-end of U6 snRNA by TUT1. PMID: 28589955
    2. Star-PAP possesses tumor-suppressing activity. PMID: 28151486
    3. Star-PAP-specific polyadenylation sites usage regulates the expression of the eukaryotic translation initiation factor EIF4A1, the tumor suppressor gene PTEN and the long non-coding RNA NEAT1. PMID: 28911096
    4. Star-PAP recognises a unique nucleotide motif on its target mRNA.CstF-64 and 3'-UTR cis-element determine Star-PAP specificity for target mRNA selection by excluding poly A polymerase. PMID: 26496945
    5. Nucleotidyl transferase TUT1 inhibits lipogenesis in osteosarcoma cells through regulation of microRNA-24 and microRNA-29a. PMID: 25142229
    6. Star-PAP controls E6 mRNA polyadenylation and expression and modulates wild-type p53 levels. PMID: 23416977
    7. The human TUT1 nucleotidyl transferase is a global regulator of microRNA abundance. PMID: 23874977
    8. Star-PAP and its regulatory molecules form a signaling nexus at the 3'-end of target mRNAs to control the expression of select group of genes including the ones involved in stress responses. (Review) PMID: 23306079
    9. PIPKIalpha, PI4,5P(2), and PKCdelta regulate Star-PAP control of BIK expression and induction of apoptosis. PMID: 22244330
    10. The data support a model where Star-PAP binds to the pre-mRNA, recruits the CPSF complex to the 3'-end of pre-mRNA and then defines cleavage by CPSF 73 and subsequent polyadenylation of its target mRNAs. PMID: 21102410
    11. PIPKIalpha co-localizes at nuclear speckles and interacts with a newly identified non-canonical poly(A) polymerase, Star-PAP; the activity of Star-PAP can be specifically regulated by PtdIns4,5P2 PMID: 18288197
    12. These data indicate that CKIalpha, PIPKIalpha, and Star-PAP function together to modulate the production of specific Star-PAP messages. PMID: 18305108

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus, nucleolus. Nucleus speckle.
  • 蛋白家族：
    DNA polymerase type-B-like family
  • 組織特異性：
    Widely expressed.
  • 數據庫鏈接：

    HGNC: 26184

    OMIM: 610641

    KEGG: hsa:64852

    STRING: 9606.ENSP00000308000

    UniGene: Hs.728983



主站蜘蛛池模板： 国产情侣一区二区| 青青草原综合久久大伊人| 色偷偷av亚洲男人的天堂| 忍不住的亲子中文字幕| 亚洲一线二线三线写真| 午夜免费无码福利视频麻豆| 久久精品国产亚洲a片高清不卡| 最新的国产成人精品2021| 亚洲乱码一卡二卡卡3卡4卡 | 国产成人a无码短视频| 精品综合久久久久久8888| 国产精品永久在线观看| 欧美精品亚洲精品日韩传电影| 成全世界免费高清观看| 日本中文字幕人妻不卡dvd| 亚洲国产av无码综合原创国产| 上海少妇高潮狂叫喷水了| 亚洲熟女乱色一区二区三区| 国产成人精品三上悠亚| 亚洲欧洲av无码专区| 人妻丝袜无码国产一区| 亚洲第一a在线观看网站| 国产一卡2卡3卡4卡网站精品| 在厨房拨开内裤进入毛片| 无修无码h里番在线播放网站| 欧洲熟妇色xxxxx欧美| 人妻在线无码一区二区三区| 国产熟女一区二区三区五月婷| 久热国产vs视频在线观看| 麻豆自媒体 一区 二区| 肥白大屁股bbwbbwhd| 免费看一区二区三区四区| 久久不见久久见免费影院 | 青青草av一区二区三区| 国产欧美另类精品久久久| 欧美 日韩 国产 另类 图片区| 国产精品久久久久9999高清| 中文字幕在线亚洲精品| 日韩精品一区二区三区影院| 亚洲 欧美 国产 综合免费| 亚洲精品乱码久久久久久v|