在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Sorbin and SH3 domain-containing protein 2 (SORBS2), partial

Recombinant Human Sorbin and SH3 domain-containing protein 2 (SORBS2), partial

  • 中文名稱：
    人SORBS2重組蛋白
  • 貨號：
    CSB-YP022405HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SORBS2重組蛋白
  • 貨號：
    CSB-EP022405HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SORBS2重組蛋白
  • 貨號：
    CSB-BP022405HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SORBS2重組蛋白
  • 貨號：
    CSB-MP022405HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SORBS2
  • Uniprot No.：
  • 別名：
    Arg binding protein 2; Arg-binding protein 2; Arg/Abl interacting protein 2; Arg/Abl interacting protein; Arg/Abl-interacting protein 2; ArgBP2; KIAA0777; PRO0618; sorbin and SH3 domain containing 2; Sorbin and SH3 domain-containing protein 2; Sorbin; Sorbs2; SRBS2_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder.
  • 基因功能參考文獻：
    1. By enhancing the stability of gene transcripts, SORBS2 suppresses ovarian cancer invasiveness and affects monocyte to myeloid-derived suppressor cell and M2-like macrophage polarization, eliciting a tumor-suppressive immune microenvironment. PMID: 29548303
    2. results thus contribute to the knowledge of the regulatory mechanism of HSF1 in down-regulating ArgBP2, providing new insight into the HSF1&MORC2-PRC2-ArgBP2 signaling pathway and a better understanding of their functions in gastric cancer cells. PMID: 29339121
    3. In spite of our finding that SORBS2 is clearly a component of the apical junction complex, it does not appear to be required for either normal tight- or adherens junction assembly, structure or function or for growth factor-mediated changes in tight junction dynamics PMID: 28961272
    4. SORBS2 transcription is activated by telomere position effect-over long distance upon telomere shortening in muscle cells from patients with facioscapulohumeral dystrophy PMID: 26359233
    5. ArgBP2 inhibits proliferation, migration, and invasion of gastric cancer cells.MORC2 down-regulates the ArgBP2 via histone methylation in gastric cancer cells. PMID: 26476214
    6. This study confirmed that SORBS2 as genetic modifiers of age at onset of Alzheimer disease. PMID: 26214276
    7. ArgBP2 interaction with alpha-actinin and actin stress fibers inhibits cell migration PMID: 25429109
    8. Tyrosine phosphorylation of ARGBP2 interferes with a SH3 mediated self-interaction, thereby controlling its panel of interacting partners and related functions. PMID: 24475245
    9. SORBS2 and TLR3 induce premature senescence in primary human fibroblasts and keratinocytes. PMID: 24165198
    10. Sarcoplasmic sorbin and SH3 domain-containing protein 2 is released from damaged cardiac tissue into the bloodstream upon lethal acute myocardial infarction. PMID: 24342996
    11. the expression and localization of hArgBP2 in osteosarcoma MG-63 cells PMID: 22394629
    12. In epithelial NMuMG cells, immunofluorescence analyses revealed localization of ArgBP2 at tight junctions and mutation analyses found a second SH3 domain to be important for ArgBP2 localization to the cell-cell contact sites. PMID: 22431180
    13. A co-localization of SORBS2 and eEF1A was evidenced at level of plasma membrane, thus suggesting the involvement of eEF1A1 in novel key signal transduction complexes. PMID: 21689717
    14. Reconstitution of SORBS2 expression resulted significant reduction in cell proliferation, colony formation and anchorage-independent growth in CaSki, HPKII and HaCaT cells, whereby anchorage-independent growth could only be investigated for CaSki cells PMID: 21602178
    15. Results indicate that ArgBP2 may play an important role in the assembly and maintenance of myofibrils in cardiomyocytes. PMID: 20886612
    16. CIP4 is a new ArgBP2 interacting protein that modulates the ArgBP2 mediated control of WAVE1 phosphorylation and cancer cell migration. PMID: 19631450
    17. complexation with Cbl mediates ubiquitination and degradation of c-Abl PMID: 12475393
    18. regulates cytoskeletal organization and signal transduction--review PMID: 12510380
    19. The sorbin N- and C-termini were localized in the human ArgBP2 gene locus; they are spliced to the 5' and 3' ends of the 95% homologous region; thus, a revised human sorbin nucleotide sequence is proposed. PMID: 15949647
    20. Loss of ArgBP2 is associated with pancreatic cancer. PMID: 18559503

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, perinuclear region. Apical cell membrane. Cell junction, focal adhesion. Cell projection, lamellipodium.
  • 組織特異性：
    Abundantly expressed in heart. In cardiac muscle cells, located in the Z-disks of sarcomere. Also found, but to a lower extent, in small and large intestine, pancreas, thymus, colon, spleen, prostate, testis, brain, ovary and epithelial cells. In the panc
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24098

    OMIM: 616349

    KEGG: hsa:8470

    STRING: 9606.ENSP00000284776

    UniGene: Hs.481342



主站蜘蛛池模板： 网友自拍区视频精品| 无套中出极品少妇白浆| 久久免费的精品国产v∧| 亚洲一卡一卡二新区无人区| 国色天香网www在线观看| 丝袜无码专区人妻视频| 亚洲色偷偷偷网站色偷一区 | 亚洲精品第一国产综合精品| 性一交一乱一伦一| 久久不见久久见免费视频下载| 天天做天天爱夜夜夜爽毛片| 双腿张开被9个黑人调教影片 | 国产欧美丝袜在线二区| 人妻av中文字幕无码专区| 国产舌乚八伦偷品w中| 亚洲日韩一区二区一无码| 精品无码乱码av| 日本久久久久久久久久加勒比| 国产99视频精品免费视频6| 国产情侣一区二区| 亚洲成av人在线视| 欧美成人精品福利视频| 国产精品人成视频免费国产| 丝袜美腿一区二区三区| 无尺码精品产品视频| 日产精品卡1卡2卡三卡在线| 日韩国产综合精选| 伊人色综合一区二区三区| 国产成人亚洲综合精品| 人人妻人人爽人人添夜夜欢视频 | 国产成人午夜福利免费无码r| 99国产精品久久久久久久成人热| 亚洲中文字幕无码一久久区| 精品久久国产综合婷婷五月| 久久国产av影片| 亚洲婷婷五月综合狠狠爱| 亚洲 综合 欧美在线视频| 国产99在线 | 中国| 日韩一欧美内射在线观看| 国内精品视这里只有精品| 亚洲一区二区色情苍井空|