在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Solute carrier family 15 member 4 (SLC15A4), partial

Recombinant Human Solute carrier family 15 member 4 (SLC15A4), partial

  • 中文名稱：
    人SLC15A4重組蛋白
  • 貨號(hào)：
    CSB-YP843279HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SLC15A4重組蛋白
  • 貨號(hào)：
    CSB-EP843279HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SLC15A4重組蛋白
  • 貨號(hào)：
    CSB-EP843279HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SLC15A4重組蛋白
  • 貨號(hào)：
    CSB-BP843279HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SLC15A4重組蛋白
  • 貨號(hào)：
    CSB-MP843279HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    SLC15A4; PHT1; PTR4; FP12591; Solute carrier family 15 member 4; Peptide transporter 4; Peptide/histidine transporter 1; hPHT1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response. Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans. Transporter activity is pH-dependent and maximized in the acidic lysosomal environment. Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand, and L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (tri-DAP), the NOD1 ligand. Required for TLR7, TLR8 and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs). Independently of its transporter activity, also promotes the recruitment of innate immune adapter TASL to endolysosome downstream of TLR7, TLR8 and TLR9: TASL recruitment leads to the specific recruitment and activation of IRF5. Required for isotype class switch recombination to IgG2c isotype in response to TLR9 stimulation. Required for mast cell secretory-granule homeostasis by limiting mast cell functions and inflammatory responses.
  • 基因功能參考文獻(xiàn)：
    1. Targeted sequencing of two candidate genes, SLC20A1 and SLC15A4, of the solute carrier membrane transport protein family in 200 additional patients demonstrated two further variants predicted as damaging for combined hormone deficiency. PMID: 29261175
    2. Under a dominant model the rs1385374 (TT+CT) SNP carried a higher risk of Systemic Lupus Erythematosus (SLE) than (CC). Under a codominant model the genotype frequencies of rs3765108 AG and rs7308691 AT were significantly higher in the SLE group than the control group. One SLC15A4 haplotype (TA), which consists of 2 SNPs (rs959989 and rs983492), was associated with SLE PMID: 27362648
    3. Mutations in SLC15A4,a peptide transporter in NFkB signaling pathway, have been implicated in Systemic Lupus Erythematosus development in susceptible individuals. PMID: 25034154
    4. Report role of SLC15A4 genetic variants in confering risk of systemic lupus erythematosus in Chinese population. PMID: 24091983
    5. LNCaP expresses high levels of PEPT2 and PHT1.PC-3 demonstrates strong expression of PEPT1 and PHT1. PMID: 22950754
    6. PEPT1,PEPT2, PHT1, and PHT2 are expressed in human nasal epithelium. PMID: 21366347
    7. Significant associations were found for the single nucleotide polymorphism rs10847697 of SLC15A4 with discoid rash in patients with systemic lupus erythematosus PMID: 20516000

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Lysosome membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    PTR2/POT transporter (TC 2.A.17) family
  • 組織特異性：
    Highly expressed in skeletal muscle. Moderately expressed in kidney, liver, and heart. Weakly expressed in colon and brain. Expressed in low levels throughout the gastrointestinal tract and in Caco-2 cells. Expressed in retinal fragment epithelium (RPE) a
  • 數(shù)據(jù)庫鏈接：

    HGNC: 23090

    OMIM: 615806

    KEGG: hsa:121260

    STRING: 9606.ENSP00000266771

    UniGene: Hs.507260



主站蜘蛛池模板： 2021麻豆剧传媒一二三区| 免费人成视频在线观看视频| 2020精品自拍视频曝光| 色老头精品午夜福利视频| 粗大的内捧猛烈进出视频| 色先锋av资源中文字幕| 久久人人爽人人爽人人片dvd| 女被啪到深处喷水gif动态图| 国产 av 仑乱内谢| 日韩精品 中文字幕 视频在线| 夜夜躁日日躁狠狠久久av| 午夜时刻免费入口| 欧美综合自拍亚洲图久青草| 欧美白丰满老太aaa片| 欧美牲交a欧牲交aⅴ久久| 国产成人a人亚洲精品无码| 国产精品欧美成人片| 男ji大巴进入女人的直播| 亚洲色大成网站www| 动漫精品专区一区二区三区不卡| 日韩欧美亚洲综合久久影院ds| 97精品超碰一区二区三区| 999国内精品永久免费视频| 婷婷五月深爱憿情网| 亚洲国产成人久久综合碰碰| 国产在线国偷精品产拍| 毛色毛片免费观看| 天天躁夜夜躁狠狠躁2021| 免免费国产aaaaa片| 久9re热视频这里只有精品| 亚洲αⅴ无码乱码在线观看性色| 国产福利萌白酱精品一区| 中文无码日韩欧| 无码专区aaaaaa免费视频| 国产制服丝袜亚洲高清| 国产98在线 | 欧美| 十八18禁国产精品www| 五月色丁香婷婷网蜜臀av| 精品免费看国产一区二区| 欧美成人免费一区二区| 精品国产三级a在线观看|