在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SLC15A4 Antibody

SLC15A4 Antibody

  • 中文名稱：
    SLC15A4兔多克隆抗體
  • 貨號：
    CSB-PA843279LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA843279LA01HU diluted at 1:200 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA843279LA01HU diluted at 1:200 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of HepG2 cells with CSB-PA843279LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SLC15A4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    SLC15A4 antibody; PHT1 antibody; PTR4 antibody; FP12591 antibody; Solute carrier family 15 member 4 antibody; Peptide transporter 4 antibody; Peptide/histidine transporter 1 antibody; hPHT1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Solute carrier family 15 member 4 protein (243-317AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，SLC15A4 Antibody (CSB-PA843279LA01HU)，的標記方式是Non-conjugated。對于SLC15A4 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA843279LB01HU SLC15A4 Antibody, HRP conjugated ELISA
    FITC CSB-PA843279LC01HU SLC15A4 Antibody, FITC conjugated
    Biotin CSB-PA843279LD01HU SLC15A4 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response. Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans. Transporter activity is pH-dependent and maximized in the acidic lysosomal environment. Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand, and L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (tri-DAP), the NOD1 ligand. Required for TLR7, TLR8 and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs). Independently of its transporter activity, also promotes the recruitment of innate immune adapter TASL to endolysosome downstream of TLR7, TLR8 and TLR9: TASL recruitment leads to the specific recruitment and activation of IRF5. Required for isotype class switch recombination to IgG2c isotype in response to TLR9 stimulation. Required for mast cell secretory-granule homeostasis by limiting mast cell functions and inflammatory responses.
  • 基因功能參考文獻：
    1. Targeted sequencing of two candidate genes, SLC20A1 and SLC15A4, of the solute carrier membrane transport protein family in 200 additional patients demonstrated two further variants predicted as damaging for combined hormone deficiency. PMID: 29261175
    2. Under a dominant model the rs1385374 (TT+CT) SNP carried a higher risk of Systemic Lupus Erythematosus (SLE) than (CC). Under a codominant model the genotype frequencies of rs3765108 AG and rs7308691 AT were significantly higher in the SLE group than the control group. One SLC15A4 haplotype (TA), which consists of 2 SNPs (rs959989 and rs983492), was associated with SLE PMID: 27362648
    3. Mutations in SLC15A4,a peptide transporter in NFkB signaling pathway, have been implicated in Systemic Lupus Erythematosus development in susceptible individuals. PMID: 25034154
    4. Report role of SLC15A4 genetic variants in confering risk of systemic lupus erythematosus in Chinese population. PMID: 24091983
    5. LNCaP expresses high levels of PEPT2 and PHT1.PC-3 demonstrates strong expression of PEPT1 and PHT1. PMID: 22950754
    6. PEPT1,PEPT2, PHT1, and PHT2 are expressed in human nasal epithelium. PMID: 21366347
    7. Significant associations were found for the single nucleotide polymorphism rs10847697 of SLC15A4 with discoid rash in patients with systemic lupus erythematosus PMID: 20516000

    顯示更多

    收起更多

  • 亞細胞定位：
    Lysosome membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    PTR2/POT transporter (TC 2.A.17) family
  • 組織特異性：
    Highly expressed in skeletal muscle. Moderately expressed in kidney, liver, and heart. Weakly expressed in colon and brain. Expressed in low levels throughout the gastrointestinal tract and in Caco-2 cells. Expressed in retinal fragment epithelium (RPE) a
  • 數據庫鏈接：

    HGNC: 23090

    OMIM: 615806

    KEGG: hsa:121260

    STRING: 9606.ENSP00000266771

    UniGene: Hs.507260



主站蜘蛛池模板： 香港三级日本三级a视频| 小荡货好紧好爽奶头大视频| 任我撸在线视频| 无码人妻丰满熟妇啪啪7774| 女性自慰网站免费观看w | 四虎永久在线精品视频免费观看| 亚洲精品午夜一区人人爽| 大色综合色综合网站| 国产97在线 | 亚洲| 97成人精品国语自产拍| 狂野欧美激情性xxxx在线观看| 国产色无码精品视频免费| 狠狠躁夜夜躁人人爽天天天天97| 久久tv中文字幕首页| 综合欧美日韩国产成人| 精品人妻少妇一区二区| 免费观看全黄做爰的视频| 日本护士毛茸茸xx| 国产 日韩 中文字幕 制服| 欧美老熟妇乱子伦视频| 日本牲交大片免费观看| 麻豆日产精品卡2卡3卡4卡5卡| 亚洲成a人无码| 西西人体www大胆高清| 久久精品国产精品久久久| av边做边流奶水无码免费| 久久99精品久久只有精品| 少妇精品导航| 午夜男女无遮掩免费视频| 欧美性潮喷xxxxx免费视频看| 亚洲国产精品无码久久久久高潮| 无遮挡午夜男女xx00动态| 国产啪精品视频网站免费尤物| 亚洲电影在线观看| 在线看片免费人成视频福利 | 99久久精品6在线播放| 西欧free性满足hd老熟妇| 青青青国产免a在线观看| 国产成+人欧美+综合在线观看| 亲嘴扒胸摸屁股激烈网站| 情欲少妇人妻100篇|