在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Soluble calcium-activated nucleotidase 1 (CANT1), partial

In Stock
  • 中文名稱:
    Recombinant Human Soluble calcium-activated nucleotidase 1 (CANT1), partial
  • 貨號:
    CSB-EP848824HUc7
  • 規格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
    CANT1
  • Uniprot No.:
  • 別名:
    SCAN-1;Apyrase homolog;Putative MAPK-activating protein PM09;Putative NF-kappa-B-activating protein 107
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    42.3 kDa
  • 表達區域:
    80-397aa
  • 氨基酸序列
    GQAPANWYNDTYPLSPPQRTPAGIRYRIAVIADLDTESRAQEENTWFSYLKKGYLTLSDSGDKVAVEWDKDHGVLESHLAEKGRGMELSDLIVFNGKLYSVDDRTGVVYQIEGSKAVPWVILSDGDGTVEKGFKAEWLAVKDERLYVGGLGKEWTTTTGDVVNENPEWVKVVGYKGSVDHENWVSNYNALRAAAGIQPPGYLIHESACWSDTLQRWFFLPRRASQERYSEKDDERKGANLLLSASPDFGDIAVSHVGAVVPTHGFSSFKFIPNTDDQIIVALKSEEDSGRVASYIMAFTLDGRFLLPETKIGSVKYEG
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis.
  • 基因功能參考文獻:
    1. CANT1 long non-coding RNA triggers efficient therapeutic efficacy by correcting aberrant long non-coding cascade in malignant uveal melanoma. PMID: 28330694
    2. The Multiple Epiphyseal Dysplasia (MED)phenotype is thus allelic to the more severe Desbuquois dysplasia phenotype and the results identify CANT1 as a second locus for recessively inherited MED PMID: 28742282
    3. a novel mutation of CANT1, c.467C>T (p.Ser156Phe) in 3 Indian patients with Desbuquois dysplasia, Kim type from 2 families PMID: 25486376
    4. Data studied proteoglycan synthesis in CANT1 mutated patient fibroblasts, and found significant reduced GAG synthesis in presence of beta-D-xyloside, suggesting that CANT1 plays a role in proteoglycan metabolism. PMID: 22539336
    5. Novel mutations in the CANT1 gene are reported in three cases of Desbuquois dysplasia type I and fetal hydrops. PMID: 21654728
    6. estimated the age of the founder mutation as approximately 1420 years PMID: 21412251
    7. CANT1 is commonly overexpressed in the vast majority of primary prostate carcinomas and in the precursor lesion PIN and may represent a novel prognostic biomarker PMID: 21435463
    8. The clinical-radiographic spectrum produced by CANT1 mutations must be extended to include Desbuquois dysplasia type 2 and Kim variant. PMID: 21037275
    9. Cloning, expression, and characterization of this calcium-acdtivated enzyme, a human enzyme belonging to a new family of extracellular nucleotidases. PMID: 12234496
    10. This soluble apyrase is a calcium-binding protein, as evident from saturable Ca2+-dependent changes in intrinsic tryptophan fluorescence, UV difference absorption spectra, and Ca2+-triggered transition from enzymatically inactive form to active enzyme. PMID: 12600208
    11. The importance of the dimeric state for enzymatic activity and biological function in this nucleotidase by mutating isoleucine 170, is investigated. PMID: 18067325
    12. human soluble calcium-activated nucleotidase inhibits coagulation in vitro and thrombosis in vivo PMID: 18222531
    13. The two novel ETV4 fusion partners possess as predominant common characteristics androgen-induction and prostate-specific expression. PMID: 18451133
    14. Mutations in CANT1 in Desbuquois dysplasia are identified. PMID: 19853239

    顯示更多

    收起更多

  • 相關疾病:
    Desbuquois dysplasia 1 (DBQD1); Epiphyseal dysplasia, multiple, 7 (EDM7)
  • 亞細胞定位:
    Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Cell membrane. Note=Processed form: Secreted.
  • 蛋白家族:
    Apyrase family
  • 組織特異性:
    Widely expressed.
  • 數據庫鏈接:

    HGNC: 19721

    OMIM: 251450

    KEGG: hsa:124583

    STRING: 9606.ENSP00000307674

    UniGene: Hs.8859



主站蜘蛛池模板: 国产成人三级一区二区在线观看一| 三级全黄的视频在线观看| 色综合久久久无码中文字幕波多| 真实的国产乱xxxx在线| 久久久久国产精品| 日韩69永久免费视频| 三级特黄60分钟在线观看| 亚洲国产精品成人久久| 国产精品高潮呻吟av久久无吗| 怀孕挺大肚子疯狂高潮av毛片| 亚洲欧洲日韩综合久久| 国产日韩一区二区三免费高清| 四虎国产精品永久免费网址| 内射小寡妇无码| 亚洲精品乱码久久久久久自慰| 成熟丰满熟妇av无码区| 日韩理论午夜无码| 成人女人黄网站免费视频| 少妇裸交aa大片| 天天做天天爱夜夜爽毛片毛片| 欧美又大粗又爽又黄大片视频| 内射巨臀欧美在线视频| 成人免费无码视频在线网站| 成人久久久久久久久久久| 精品国产黑色丝袜高跟鞋| 国产在线看片免费视频| 亚洲熟妇av一区| 国产成人久久精品77777综合| 国产麻豆精品av在线观看| 国产又色又爽又黄的视频在线观看 | 亚洲一区av无码专区在线观看 | 成人麻豆日韩在无码视频| 台湾无码av一区二区三区| 午夜福利92国语| 无码一区二区三区| 国产精品无打码在线播放| 欧美乱码卡一卡二卡三新区| 精品人妻av一区二区三区| 大香线蕉伊人超碰| 亚洲成aⅴ人片在线观| 毛片免费视频肛交颜射免费视频|