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  4. Recombinant Human Sodium/potassium/calcium exchanger 1 (SLC24A1), partial

Recombinant Human Sodium/potassium/calcium exchanger 1 (SLC24A1), partial

  • 中文名稱：
    人SLC24A1重組蛋白
  • 貨號：
    CSB-YP021469HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SLC24A1重組蛋白
  • 貨號：
    CSB-EP021469HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SLC24A1重組蛋白
  • 貨號：
    CSB-EP021469HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SLC24A1重組蛋白
  • 貨號：
    CSB-BP021469HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SLC24A1重組蛋白
  • 貨號：
    CSB-MP021469HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SLC24A1
  • Uniprot No.：
  • 別名：
    CSNB1D; HsT17412; KIAA0702; Na(+)/K(+)/Ca(2+) exchange protein 1; Na(+)/K(+)/Ca(2+)-exchange protein 1; NCKX; NCKX1; NCKX1_HUMAN; Retinal rod Na Ca+K exchanger; Retinal rod Na+/Ca+/K+ exchanger; Retinal rod Na-Ca+K exchanger; RODX; Slc24a1; Sodium/potassium/calcium exchanger 1; Solute carrier family 24 (sodium/potassium/calcium exchanger) member 1; Solute carrier family 24 member 1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).
  • 基因功能參考文獻：
    1. We report the association of many previously unreported variants with retinal disease, as well as new disease phenotypes associated with known genes, including the first association of the SLC24A1 gene with retinitis pigmentosa PMID: 27624628
    2. The index patient and his affected brother carry a homozygous single-nucleotide variants (SNVs) in sodium-calcium, potassium exchanger (SLC24A1) (c.2401G > T). PMID: 26822852
    3. A mutation in SLC24A1 is implicated in autosomal-recessive congenital stationary night blindness. PMID: 20850105
  • 相關疾病：
    Night blindness, congenital stationary, 1D (CSNB1D)
  • 亞細胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family, SLC24A subfamily
  • 組織特異性：
    Expressed in the retina, particularly in the inner segment, outer and inner nuclear layers, and ganglion cell layer.
  • 數據庫鏈接：

    HGNC: 10975

    OMIM: 603617

    KEGG: hsa:9187

    STRING: 9606.ENSP00000261892

    UniGene: Hs.173092



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