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SLC24A1 Antibody

  • 中文名稱：
    SLC24A1兔多克隆抗體
  • 貨號：
    CSB-PA021469ESR1HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA021469ESR1HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SLC24A1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SLC24A1
  • 別名：
    CSNB1D antibody; HsT17412 antibody; KIAA0702 antibody; Na(+)/K(+)/Ca(2+) exchange protein 1 antibody; Na(+)/K(+)/Ca(2+)-exchange protein 1 antibody; NCKX antibody; NCKX1 antibody; NCKX1_HUMAN antibody; Retinal rod Na Ca+K exchanger antibody; Retinal rod Na+/Ca+/K+ exchanger antibody; Retinal rod Na-Ca+K exchanger antibody; RODX antibody; Slc24a1 antibody; Sodium/potassium/calcium exchanger 1 antibody; Solute carrier family 24 (sodium/potassium/calcium exchanger) member 1 antibody; Solute carrier family 24 member 1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Sodium/potassium/calcium exchanger 1 protein (330-452AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).
  • 基因功能參考文獻：
    1. We report the association of many previously unreported variants with retinal disease, as well as new disease phenotypes associated with known genes, including the first association of the SLC24A1 gene with retinitis pigmentosa PMID: 27624628
    2. The index patient and his affected brother carry a homozygous single-nucleotide variants (SNVs) in sodium-calcium, potassium exchanger (SLC24A1) (c.2401G > T). PMID: 26822852
    3. A mutation in SLC24A1 is implicated in autosomal-recessive congenital stationary night blindness. PMID: 20850105
  • 相關疾病：
    Night blindness, congenital stationary, 1D (CSNB1D)
  • 亞細胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family, SLC24A subfamily
  • 組織特異性：
    Expressed in the retina, particularly in the inner segment, outer and inner nuclear layers, and ganglion cell layer.
  • 數據庫鏈接：

    HGNC: 10975

    OMIM: 603617

    KEGG: hsa:9187

    STRING: 9606.ENSP00000261892

    UniGene: Hs.173092



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