Recombinant Human Sodium/hydrogen exchanger 8 (SLC9A8 KIAA0939 NHE8)

中文名稱：
貨號：

CSB-YP021739HU
規(guī)格：
來源：

Yeast
其他：

中文名稱：
貨號：

CSB-EP021739HU
規(guī)格：
來源：

E.coli
其他：

中文名稱：
貨號：

CSB-EP021739HU-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：
貨號：

CSB-BP021739HU
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：
貨號：

CSB-MP021739HU
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
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靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

SL9A8
Uniprot No.：

Q9Y2E8
別名：

Sodium/hydrogen exchanger 8; Na(+/H(+; exchanger 8; NHE-8; Solute carrier family 9 member 8; SLC9A8 KIAA0939 NHE8
種屬：

Homo sapiens (Human)
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
基因功能參考文獻：
1. work has uncovered a crucial role of NHE8 in acrosome biogenesis and suggests that some forms of human globozoospermia might be caused by a loss of function of this Na(+)/H(+) exchanger. PMID: 28476888
2. NHE8 is expressed in goblet cells, and the inflammatory cytokine TNF-alpha downregulates NHE8 expression by a transcriptional mechanism. PMID: 26564720
3. Exonic mutations in NHE8 cannot account for congenital sodium diarrhea. PMID: 21666503
4. These data point to a role for the ion exchange activity of NHE8 being required to maintain endosome morphology. PMID: 20719963
5. EGF inhibits intestinal NHE8 gene expression by reducing its basal transcription. PMID: 20375273
6. NHE8 is expressed along the gastrointestinal tract and NHE8 is a functional Na(+)/H(+) exchanger with kinetic characteristics that differ from other apically expressed NHE isoforms. PMID: 18209477
7. Tumor necrosis factor-alpha downregulates intestinal NHE8 expression by reducing basal promoter activity. PMID: 19109523
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亞細胞定位：

Golgi apparatus membrane; Multi-pass membrane protein.
蛋白家族：

Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
組織特異性：

Ubiquitous. Strongly expressed in skeletal muscle and kidney.
數(shù)據(jù)庫鏈接：

HGNC: 20728

OMIM: 612730

KEGG: hsa:23315

STRING: 9606.ENSP00000354966

UniGene: Hs.444202