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  4. SLC9A8 Antibody

SLC9A8 Antibody

  • 中文名稱：
    SLC9A8兔多克隆抗體
  • 貨號：
    CSB-PA008354
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of Jurkat cells using NHE-8 Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    SLC9A8
  • 別名：
    Na(+)/H(+) exchanger 8 antibody; NHE 8 antibody; NHE-8 antibody; NHE8 antibody; SL9A8_HUMAN antibody; Slc9a8 antibody; Sodium/ hydrogen exchanger 8 antibody; Sodium/hydrogen exchanger 8 antibody; solute carrier family 9 (sodium/hydrogen exchanger); member 8 antibody; Solute carrier family 9 member 8 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human NHE-8.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IHC 1:200-1:1000
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
  • 基因功能參考文獻：
    1. work has uncovered a crucial role of NHE8 in acrosome biogenesis and suggests that some forms of human globozoospermia might be caused by a loss of function of this Na(+)/H(+) exchanger. PMID: 28476888
    2. NHE8 is expressed in goblet cells, and the inflammatory cytokine TNF-alpha downregulates NHE8 expression by a transcriptional mechanism. PMID: 26564720
    3. Exonic mutations in NHE8 cannot account for congenital sodium diarrhea. PMID: 21666503
    4. These data point to a role for the ion exchange activity of NHE8 being required to maintain endosome morphology. PMID: 20719963
    5. EGF inhibits intestinal NHE8 gene expression by reducing its basal transcription. PMID: 20375273
    6. NHE8 is expressed along the gastrointestinal tract and NHE8 is a functional Na(+)/H(+) exchanger with kinetic characteristics that differ from other apically expressed NHE isoforms. PMID: 18209477
    7. Tumor necrosis factor-alpha downregulates intestinal NHE8 expression by reducing basal promoter activity. PMID: 19109523

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  • 亞細胞定位：
    Golgi apparatus membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
  • 組織特異性：
    Ubiquitous. Strongly expressed in skeletal muscle and kidney.
  • 數據庫鏈接：

    HGNC: 20728

    OMIM: 612730

    KEGG: hsa:23315

    STRING: 9606.ENSP00000354966

    UniGene: Hs.444202



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