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  4. Recombinant Human Small nuclear ribonucleoprotein-associated protein N (SNRPN)

Recombinant Human Small nuclear ribonucleoprotein-associated protein N (SNRPN)

  • 中文名稱：
    人SNRPN重組蛋白
  • 貨號：
    CSB-YP022343HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SNRPN重組蛋白
  • 貨號：
    CSB-EP022343HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SNRPN重組蛋白
  • 貨號：
    CSB-EP022343HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SNRPN重組蛋白
  • 貨號：
    CSB-BP022343HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SNRPN重組蛋白
  • 貨號：
    CSB-MP022343HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SNRPN
  • Uniprot No.：
  • 別名：
    HCERN3; PWCR; RSMN_HUMAN; RT LI; RTLI; SM D; Sm N; Sm protein D; Sm protein N; Sm-D; Sm-N; Small nuclear ribonucleoprotein associated protein N; Small nuclear ribonucleoprotein polypeptide N; Small nuclear ribonucleoprotein-associated protein N; SMD; SmN; SNRNP N; snRNP-N; SNRNPN; SNRPN; SNURF SNRPN; Tissue specific splicing protein; Tissue-specific-splicing protein
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-240
  • 氨基酸序列
    MTVGKSSKML QHIDYRMRCI LQDGRIFIGT FKAFDKHMNL ILCDCDEFRK IKPKNAKQPE REEKRVLGLV LLRGENLVSM TVEGPPPKDT GIARVPLAGA AGGPGVGRAA GRGVPAGVPI PQAPAGLAGP VRGVGGPSQQ VMTPQGRGTV AAAAVAATAS IAGAPTQYPP GRGTPPPPVG RATPPPGIMA PPPGMRPPMG PPIGLPPARG TPIGMPPPGM RPPPPGIRGP PPPGMRPPRP
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    May be involved in tissue-specific alternative RNA processing events.
  • 基因功能參考文獻：
    1. The first study reporting an association between variability in the SNRPN gene and the risk of being obese. PMID: 28387446
    2. we have confirmed that SNRPN methylation increases with age, which raises further questions regarding the role of SNRPN expression during the aging process. PMID: 26535694
    3. the cases with partial loss of methylation in KCNQ1OT1 and SNRPN present clinical features different to those associated with the corresponding imprinting syndromes PMID: 26106604
    4. Knockdown of SNRPN was demonstrated to significantly inhibit medulloblastoma cell growth and induce G2/M phase arrest in vitro. PMID: 25571951
    5. Data indicate that Sm nuclear antigen SmD-specific clonotypic IgGs showed extensive V- region hypermutation. PMID: 25577500
    6. indicate that SmN expression reduces the level of mature U2 snRNP, leading to alternative splicing PMID: 25238490
    7. The methylation patterns of the promoters of MTHFR and SNRPN are associated with changes in sperm motility and morphology, which could lead to male infertility. PMID: 24365028
    8. Human amniotic fluid mesenchymal stem cells contain a unique epigenetic signature during in vitro cell culture. H19 and KCNQ1OT1 possessed a substantial degree of hypermethylation status, and variable DNA methylation patterns of SNRPN was observed. PMID: 23040914
    9. In the skeletal muscle of neonate pigs, both NECD and SNRPN were maternally imprinted, while UBE3A was not imprinted. PMID: 22711311
    10. genetic association studies using 1,000 white subjects from Midwestern United States: Three copy number variations (CNV) in PWCR are associated with body fat mass, with a higher copy number (CN) associated with an increase of in body fat mass. PMID: 21233802
    11. Differences between genetic subtypes were also statistically significant in Prader Willi syndrome PMID: 21227640
    12. Variable methylation of the imprinted gene, SNRPN, supports a relationship between intracranial germ cell tumours and neural stem cells. PMID: 20582452
    13. SNRPN gene is imprinted, with monoallelic expression from the paternal allele in fetal brain and heart, and in adult brain. PMID: 7512861
    14. MEG3 and SNRPN genes are abnormally methylated in AML and MDS patients, and methylation of MEG3, but not SNRPN, confers worse overall prognosis. PMID: 19595458
    15. Methylation imprints of the imprint control region of the SPRPN-gene were studied in gametes and preimplantation embryos. ametes PMID: 14500540
    16. SMB and CD2BP2-GYF interact in the spliceosome PMID: 15105431
    17. Identification of cis- and trans-acting regulatory elements within the endogenous SNRPN 5' region. PMID: 16116039
    18. a possibly inactivating mutation in the SNRPN minimal promoter region was identified in Prader-Willi syndrome PMID: 17262171
    19. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 18361419
    20. A mouse model for Prader-Willi syndrome. Deletion of Snrpn gene and putative imprinting-centre is associated with absent expression of the imprinted genes Zfp127, Ndn and Ipw, and phenotypes similar to those found in Prader-Willi infants. PMID: 9590284

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    SnRNP SmB/SmN family
  • 組織特異性：
    Expressed in brain and lymphoblasts.
  • 數據庫鏈接：

    HGNC: 11164

    OMIM: 182279

    KEGG: hsa:6638

    STRING: 9606.ENSP00000306223

    UniGene: Hs.564847



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