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SNRPN Antibody

  • 中文名稱:
    SNRPN兔多克隆抗體
  • 貨號:
    CSB-PA011056
  • 規(guī)格:
    ¥1090
  • 圖片:
    • Western Blot analysis of HeLa cells using SNRPN Polyclonal Antibody.
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    SNRPN
  • 別名:
    HCERN3 antibody; PWCR antibody; RSMN_HUMAN antibody; RT LI antibody; RTLI antibody; SM D antibody; Sm N antibody; Sm protein D antibody; Sm protein N antibody; Sm-D antibody; Sm-N antibody; Small nuclear ribonucleoprotein associated protein N antibody; Small nuclear ribonucleoprotein polypeptide N antibody; Small nuclear ribonucleoprotein-associated protein N antibody; SMD antibody; SmN antibody; SNRNP N antibody; snRNP-N antibody; SNRNPN antibody; SNRPN antibody; SNURF SNRPN antibody; Tissue specific splicing protein antibody; Tissue-specific-splicing protein antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human SNRPN.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    May be involved in tissue-specific alternative RNA processing events.
  • 基因功能參考文獻:
    1. The first study reporting an association between variability in the SNRPN gene and the risk of being obese. PMID: 28387446
    2. we have confirmed that SNRPN methylation increases with age, which raises further questions regarding the role of SNRPN expression during the aging process. PMID: 26535694
    3. the cases with partial loss of methylation in KCNQ1OT1 and SNRPN present clinical features different to those associated with the corresponding imprinting syndromes PMID: 26106604
    4. Knockdown of SNRPN was demonstrated to significantly inhibit medulloblastoma cell growth and induce G2/M phase arrest in vitro. PMID: 25571951
    5. Data indicate that Sm nuclear antigen SmD-specific clonotypic IgGs showed extensive V- region hypermutation. PMID: 25577500
    6. indicate that SmN expression reduces the level of mature U2 snRNP, leading to alternative splicing PMID: 25238490
    7. The methylation patterns of the promoters of MTHFR and SNRPN are associated with changes in sperm motility and morphology, which could lead to male infertility. PMID: 24365028
    8. Human amniotic fluid mesenchymal stem cells contain a unique epigenetic signature during in vitro cell culture. H19 and KCNQ1OT1 possessed a substantial degree of hypermethylation status, and variable DNA methylation patterns of SNRPN was observed. PMID: 23040914
    9. In the skeletal muscle of neonate pigs, both NECD and SNRPN were maternally imprinted, while UBE3A was not imprinted. PMID: 22711311
    10. genetic association studies using 1,000 white subjects from Midwestern United States: Three copy number variations (CNV) in PWCR are associated with body fat mass, with a higher copy number (CN) associated with an increase of in body fat mass. PMID: 21233802
    11. Differences between genetic subtypes were also statistically significant in Prader Willi syndrome PMID: 21227640
    12. Variable methylation of the imprinted gene, SNRPN, supports a relationship between intracranial germ cell tumours and neural stem cells. PMID: 20582452
    13. SNRPN gene is imprinted, with monoallelic expression from the paternal allele in fetal brain and heart, and in adult brain. PMID: 7512861
    14. MEG3 and SNRPN genes are abnormally methylated in AML and MDS patients, and methylation of MEG3, but not SNRPN, confers worse overall prognosis. PMID: 19595458
    15. Methylation imprints of the imprint control region of the SPRPN-gene were studied in gametes and preimplantation embryos. ametes PMID: 14500540
    16. SMB and CD2BP2-GYF interact in the spliceosome PMID: 15105431
    17. Identification of cis- and trans-acting regulatory elements within the endogenous SNRPN 5' region. PMID: 16116039
    18. a possibly inactivating mutation in the SNRPN minimal promoter region was identified in Prader-Willi syndrome PMID: 17262171
    19. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 18361419
    20. A mouse model for Prader-Willi syndrome. Deletion of Snrpn gene and putative imprinting-centre is associated with absent expression of the imprinted genes Zfp127, Ndn and Ipw, and phenotypes similar to those found in Prader-Willi infants. PMID: 9590284

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  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    SnRNP SmB/SmN family
  • 組織特異性:
    Expressed in brain and lymphoblasts.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 11164

    OMIM: 182279

    KEGG: hsa:6638

    STRING: 9606.ENSP00000306223

    UniGene: Hs.564847



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