在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Signal transducing adapter molecule 1 (STAM)

  • 中文名稱:
    人STAM重組蛋白
  • 貨號:
    CSB-YP846097HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人STAM重組蛋白
  • 貨號:
    CSB-EP846097HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人STAM重組蛋白
  • 貨號:
    CSB-EP846097HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人STAM重組蛋白
  • 貨號:
    CSB-BP846097HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人STAM重組蛋白
  • 貨號:
    CSB-MP846097HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    DKFZp686J2352; HSE1 homolog; OTTHUMP00000019237; Signal transducing adapter molecule 1; signal transducing adaptor molecule (SH3 domain and ITAM motif) 1; STAM 1; STAM; STAM-1; STAM1_HUMAN
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    2-540
  • 氨基酸序列
    PLFATNPFD QDVEKATSEM NTAEDWGLIL DICDKVGQSR TGPKDCLRSI MRRVNHKDPH VAMQALTLLG ACVSNCGKIF HLEVCSRDFA SEVSNVLNKG HPKVCEKLKA LMVEWTDEFK NDPQLSLISA MIKNLKEQGV TFPAIGSQAA EQAKASPALV AKDPGTVANK KEEEDLAKAI ELSLKEQRQQ STTLSTLYPS TSSLLTNHQH EGRKVRAIYD FEAAEDNELT FKAGEIITVL DDSDPNWWKG ETHQGIGLFP SNFVTADLTA EPEMIKTEKK TVQFSDDVQV ETIEPEPEPA FIDEDKMDQL LQMLQSTDPS DDQPDLPELL HLEAMCHQMG PLIDEKLEDI DRKHSELSEL NVKVMEALSL YTKLMNEDPM YSMYAKLQNQ PYYMQSSGVS GSQVYAGPPP SGAYLVAGNA QMSHLQSYSL PPEQLSSLSQ AVVPPSANPA LPSQQTQAAY PNTMVSSVQG NTYPSQAPVY SPPPAATAAA ATADVTLYQN AGPNMPQVPN YNLTSSTLPQ PGGSQQPPQP QQPYSQKALL
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
  • 基因功能參考文獻:
    1. The VHS domain of STAM1 directs AMSH to cleave longer Lys63-linked ubiquitin chains PMID: 26601948
    2. Differential expression of the transcripts STAM connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes. PMID: 25884766
    3. ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation. PMID: 25296754
    4. STAM proteins function in a multivalent complex that sorts ubiquitinated proteins into the multivesicular body pathway. PMID: 12551915
    5. Interaction of TIMM8a with STAM1. PMID: 12745081
    6. Data suggested that association with hepatocyte growth factor-regulated tyrosine kinase substrate is a prerequisite for STAM1 function in early endosome. PMID: 15113837
    7. Hrs is a master molecule that controls in part the degradation of STAM1 and the accumulation of ubiquitinated proteins PMID: 15640163
    8. Analysis with phospho-specific antibodies indicates that 3 kinases generate a signal-specific, combinatorial phosphorylation profile of the Hrs-STAM complex, with the potential of diversifying tyrosine kinase receptor signalling through a common element. PMID: 15828871
    9. The cellular functions of UBPY are complex but clearly distinct from those of the Lys-63-ubiquitin-specific protease, AMSH, with which it shares a binding site on the SH3 domain of STAM PMID: 16520378
    10. STAMs function prominently in endoplasmic reticulum-to-Golgi trafficking, most likely through direct interactions with the coat protein II complex PMID: 19054391
    11. A novel ubiquitin binding site and the manner of ubiquitin recognition of the STAM1 VHS domain were proposed. PMID: 19111546

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族:
    STAM family
  • 組織特異性:
    Ubiquitously expressed.
  • 數據庫鏈接:

    HGNC: 11357

    OMIM: 601899

    KEGG: hsa:8027

    STRING: 9606.ENSP00000366746

    UniGene: Hs.335391



主站蜘蛛池模板: 国产欧美va欧美va香蕉在线观看| 亚洲国产果冻传媒av在线观看| 亚洲日韩精品欧美一区二区| 色狠狠av一区二区三区| 亚洲中文字幕av每天更新| 久久99精品国产99久久6男男| 狠狠躁夜夜躁人人爽天天天天| 日韩精品一区二区三区中文| 美女黄频视频大全免费的国内| 国产成人一区二区青青草原| 日本精品人妻无码77777| 人妻丰满熟妇无码区免费| 无码国产玉足脚交极品网站 | 久久综合婷婷丁香五月中文字幕| 欧美又大又色又爽aaaa片| 亚洲欧美日韩久久精品| a毛片免费全部播放自慰| 亚洲精品久久久久中文字幕二区| 久久久久夜夜夜精品国产| 久久国产美女精品久久| 色视频综合无码一区二区三区| 午夜日本大胆裸艺术| 亚洲精品动漫免费二区| 中国性欧美videofree精品| 影视先锋男人无码在线| 亚洲国产精品成人久久| 亚洲日韩久热中文字幕| 国产成年女人特黄特色毛片免| 美女视频黄频a美女大全| 国产99在线 | 中文| 亚洲精品无码成人片| 国产无套露脸在线观看| 国产成人精品无码专区| 成 人 色综合 综合网站| 久热在线播放中文字幕| 国产成人a亚洲精v品无码| 亚洲卡1卡2卡新区网站| 永久中文字幕免费视频网站| 人妻av中文系列| 在线天堂新版最新版在线8| 国产美熟女乱又伦av果冻传媒|