Recombinant Human Signal transducer and activator of transcription 6 (STAT6), partial

中文名稱：

Recombinant Human Signal transducer and activator of transcription 6 (STAT6), partial
品名簡稱：

Recombinant Human STAT6 protein, partial
貨號：

CSB-MP022816HU2
說明書：

MSDS Datasheet
規(guī)格：

￥1536
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

Greater than 85% as determined by SDS-PAGE.
生物活性：

Not Test
基因名：

STAT6
Uniprot No.：

P42226
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
來源：

Mammalian cell
分子量：

88.8 kDa
表達(dá)區(qū)域：

123-658aa
氨基酸序列

WKQEELKFKTGLRRLQHRVGEIHLLREALQKGAEAGQVSLHSLIETPANGTGPSEALAMLLQETTGELEAAKALVLKRIQIWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGGELEPKTRASLTGRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGLRFLGAPAKPPLVRADMVTEKQARELSVPQGPGAGAESTGEIINNTVPLENSIPGNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPT
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

C-terminal hFc1-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

Carries out a dual signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.
基因功能參考文獻(xiàn)：
1. is a dependable marker to differentiate solitary fibrous tumors and myofibromas PMID: 28689369
2. Inhibition of STAT6/Anoctamin-1 activation decreased proliferation, migration, or invasion of gastric cancer cells. PMID: 29466035
3. Results of our structure-function studies on STAT6 shed light on mechanism of DNA recognition by STATs in general and explain the reasons underlying STAT6's preference for N4 site DNA over N3. PMID: 27803324
4. There was no significant relationship between rs324011 and rs3024974 SNPs and psoriasis in the present study or in other studies, indicating that STAT6 is not a candidate gene for psoriasis susceptibility PMID: 28420002
5. these results showed that allergy responses further accelerated the IL-4-induced inhibition of tumor development through the activation of STAT6 pathways. PMID: 28587956
6. In this study, significant lower level of miR-214-3p and higher level of STAT6 in the intestinal mucosa of active UC patients compared with the health controls were confirmed by quantitative real-time PCR. PMID: 28752100
7. IL-13, IL-13Ralpha1, STAT6 and ZEB1 have roles in promoting epithelial-mesenchymal transition and aggressiveness of colorectal cancer cells PMID: 27533463
8. N4 DNA recognition by STAT6: structural and functional implications. PMID: 28220394
9. Data suggest that STAT6 and RANKL are involved in regulation of apoptosis, gene expression, and cell proliferation in hepatocellular carcinoma cell lines; depletion of STAT6 using RNA interference increases apoptosis; this mechanism involves down-regulation of expression of RANKL. (STAT6 = signal transducer and activator of transcription 6; RANKL = receptor activator of nuclear factor kappa B ligand) PMID: 28525794
10. The results showed that SARS coronavirus papain-like protease (PLPro) stimulated TGF-beta1-dependent expression of Type I collagen via activating STAT6 pathway. PMID: 28414040
11. High STAT6 expression is associated with melanoma. PMID: 26993600
12. Report a variant of t(14;18) negative nodal diffuse follicular lymphoma with CD23 expression, 1p36/TNFRSF14 abnormalities, and STAT6 mutations. PMID: 26965583
13. Our data indicate that hypoxic inhibition of JMJD3 activity reduces demethylation of H3K27me3, nucleosome removal, and hence induction of the STAT6 target gene CCL18, while induction of other STAT6-inducible genes such as SPINT2 remained unaffected by JMJD3. PMID: 27737800
14. The results suggest that nuclear localization and cleavage of STAT6 is important for modulating the viral latency and pathogenesis of Kaposi's sarcoma-associated herpesvirus (KSHV). PMID: 28099521
15. PVT1-derived miR-1207-5p promotes the proliferation of breast cancer cells by targeting STAT6. PMID: 28235236
16. STAT6 single-nucleotide polymorphism is associated with migraine. PMID: 27322543
17. STAT6 phosphorylation (p-STAT6) was significantly increased in TECs from both Grave's disease patients and experimental autoimmune Graves' disease mice. PMID: 27906181
18. Here, we demonstrate that pulmonary adenofibromas are neoplastic lesions harbouring NAB2-STAT6 fusion genes ,the molecular hallmark of solitary fibrous tumours. PMID: 28072477
19. STAT6 and ALDH1 immunohistochemistry can be used in the differential diagnosis of solitary fibrous tumor versus prostate-specific stromal neoplasms. PMID: 27068523
20. Our results represented that meningeal solitary fibrous tumor/hemangiopericytoma were in a single biological spectrum with NAB2-STAT6 gene fusion as was nonmeningeal solitary fibrous tumor PMID: 26927892
21. STAT6-TMEM16A-ERK1/2 signal pathway and TMEM16A channel activity are required for the IL-13-induced TMEM16A mediated mucus production PMID: 27588910
22. The detection of nuclear relocation of STAT6 with immunohistochemistry is a characteristic of solitary fibrous tumours (SFTs), and may serve as a diagnostic marker that indicates NAB2-STAT6 fusion and helps to discriminate SFTs from histological mimics. PMID: 24702701
23. The role of Th2 cytokines (IL-4, IL-13) and STAT6 in Th1/Th2 imbalance. PMID: 26781462
24. STAT6 gene (G2964) polymorphism may play a role in development of eczema among Saudi children PMID: 27018548
25. Variants of the NAB2-STAT6 fusion gene are found in solitary fibrous tumors of the meninges. PMID: 27271270
26. It is a diagnostic tumor marker for Papillary' solitary fibrous tumor/hemangiopericytoma. PMID: 26746203
27. nuclear immunohistochemistry staining can be used as a diagnostic criteria for unconventional fat-forming solitary fibrous tumors PMID: 25517867
28. the majority of intrathoracic SFTs exhibited STAT6 nuclear staining, and NAB2ex4-STAT6ex2/3 was the predominant fusion type. PMID: 26686340
29. Case Report: NAB2-STAT6 fusion in glioblastoma. PMID: 26817999
30. A constitutively activated form of STAT6 is able to bypass IL-4 upstream signalling and instruct dendritic-cell-specific functional DNA methylation changes PMID: 26758199
31. interleukin-4 regulates hematopoietic lineage choice by activating the JAK3-STAT6 pathway, which causes dendritic-cell-specific DNA demethylation PMID: 26829670
32. Immunohistochemistry results indicate that combination with ALDH1 and STAT6 can improve the diagnostic value of CD34 for solitary fibrous tumors. PMID: 26617768
33. T allele of rs324011 in STAT6 would increase the risk of atopic dermatitis (AD) occurrence in children. Haplotypes of rs324011/rs167769 were also significantly associated with childhood AD in Taiwanese population. PMID: 26048407
34. We delineate the common and rare NAB2-STAT6 fusion variants in solitary fibrous tumors PMID: 26226844
35. STAT6 is a direct target of miR-361-5p and promotes Bcl-xL expression. PMID: 26461141
36. This study confirms that meningeal Meningeal solitary fibrous tumor and hemangiopericytoma represent a histopathologic continuum linked by STAT6 nuclear expression and NAB2-STAT6 fusion similar to their soft tissue counterparts. PMID: 26883114
37. It is associated with local recurrence and late distance metastasis of brain tumors to extracranial sites. PMID: 25893823
38. bovine milk activates STAT6 in a p44/42 and p38-dependent manner in skin cells PMID: 26134630
39. IL13Ralpha2 knockdown and IL-13 treatment cooperatively upregulated the metastasis suppressor tumor protein 63 (TP63) in a STAT6-dependent manner. PMID: 26208975
40. Igepsilon gene transcription is regulated by histone modifications in the IL-4/STAT6 pathway. PMID: 25952120
41. Solitary fibrous tumor occurring in the ocular adnexa (OA) as orbital mass with proptosis. In the OA, solitary fibrous tumor demonstrates STAT6 nuclear expression. PMID: 25761539
42. Immunostaining and semiquantitative analysis revealed increased presence of phosphor-STAT6 in the pulmonary vasculature of patients with connective tissue disease-associated PAH and Schistosoma-PAH compared with normal control subjects. PMID: 26192556
43. IL-13/STAT6 signaling is modulated by Kaposi's sarcoma-associated herpesvirus to promote host cell proliferation and viral pathogenesis. PMID: 26246572
44. Eosinophilic esophagitis was associate with increased expression of STAT6. PMID: 25407941
45. This study validated the existence of the NAB2-STAT6 fusion gene in solitary fibrous tumors and examined its relation with pathological features. PMID: 25554652
46. also identified NAB2-STAT6 fusions in two hemangiopericytomas diagnosed in the past with a common variant of NAB2ex6-STAT6ex16/17 PMID: 26136329
47. results show that Cbl-b suppresses human ORMDL3 expression through STAT6 PMID: 26112603
48. TRAIL induces RANKL expression through a STAT-6 dependent transcriptional regulatory mechanism in bone marrow stromal/preosteoblast cells. PMID: 25445452
49. Strong nuclear STAT6 is largely specific for solitary fibrous tumors (SFTs). Physiologic low-level cytoplasmic/nuclear expression is common in mesenchymal neoplasia and is of uncertain significance. PMID: 25873501
50. There was no association between solitary fibrous tumors with either NAB2 exon 4-STAT6 exon 2 or 3 fusion and tumors with other fusions regarding the frequency of mutations in the examined genes (P = .201). PMID: 25582503
顯示更多

收起更多
亞細(xì)胞定位：

Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
蛋白家族：

Transcription factor STAT family
數(shù)據(jù)庫鏈接：

HGNC: 11368

OMIM: 601512

KEGG: hsa:6778

STRING: 9606.ENSP00000300134

UniGene: Hs.524518