在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Signal peptide peptidase-like 2B (SPPL2B), partial

Recombinant Human Signal peptide peptidase-like 2B (SPPL2B), partial

  • 中文名稱：
    人SPPL2B重組蛋白
  • 貨號：
    CSB-YP823457HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SPPL2B重組蛋白
  • 貨號：
    CSB-EP823457HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SPPL2B重組蛋白
  • 貨號：
    CSB-EP823457HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SPPL2B重組蛋白
  • 貨號：
    CSB-BP823457HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SPPL2B重組蛋白
  • 貨號：
    CSB-MP823457HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SPPL2B
  • Uniprot No.：
  • 別名：
    SPPL2B; IMP4; KIAA1532; PSL1; Signal peptide peptidase-like 2B; SPP-like 2B; SPPL2b; EC 3.4.23.-; Intramembrane protease 4; IMP-4; Presenilin homologous protein 4; PSH4; Presenilin-like protein 1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity. Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis.
  • 基因功能參考文獻：
    1. TfR1 N-terminal fragment is a substrate for intramembrane proteolysis by SPPL2b. PMID: 23384347
    2. The alpha-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b). PMID: 22194595
    3. SPP, SPPL2a, -2b, -2c, and -3 probably cleave type II-oriented substrate peptides as shown by consensus analysis PMID: 15385547
    4. SPPL2b is targeted through the secretory pathway to endosomes/lysosomes, whereas SPP and SPPL3 are restricted to the ER. PMID: 15998642
    5. Results demonstrate that SPPL2b utilizes multiple intramembrane cleavages to liberate the intracellular domain of tumor necrosis factor alpha into the cytosol. PMID: 16829951
    6. SPPL2a and SPPL2b mediate the intramembrane cleavage, whereas neither SPP nor SPPL3 is capable of processing the Bri2 N-terminal fragment. PMID: 17965014
    7. Alzheimer disease-like mutant SPPL2b slowed intramembrane proteolysis of tumor necrosis factor alpha and caused a relative increase of longer intracellular cleavage products. PMID: 18768471

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein; Lumenal side.
  • 蛋白家族：
    Peptidase A22B family
  • 組織特異性：
    Expressed predominantly in adrenal cortex and mammary gland.
  • 數據庫鏈接：

    HGNC: 30627

    OMIM: 608239

    KEGG: hsa:56928

    UniGene: Hs.744026



主站蜘蛛池模板： 小宝贝荡货啊用力水湿aⅴ视频 | 国产精品午夜成人免费观看 | 综合自拍亚洲综合图区欧美| 国产成人av综合久久视色| 国产午夜无码片在线观看| 亚洲综合久久成人a片| 天美麻花果冻视频大全英文版 | 影音先锋无码a∨男人资源站| 久久精品www人人做人人爽| 狠狠色狠狠色综合网| 无码av免费精品一区二区三区| 少妇高清精品毛片在线视频| 西西444www大胆无码视频| 日韩人妻少妇一区二区三区| 中文字幕乱码免费| 97人人模人人爽人人少妇| 天堂俺去俺来也www色官网| 国产在线码观看超清无码视频| 亚洲欧美综合精品成人网站| 国产精品无码无片在线观看| 三叶草欧洲码在线| 熟睡中被义子侵犯在线播放| 国产欧美日韩视频一区二区三区| 亚洲性无码av在线dvd| 亚洲熟女乱色综合亚洲小说| 国产麻豆9l精品三级站| 欧洲极品无码一区二区三区| 亚洲加勒比少妇无码av| 人妻换人妻a片爽麻豆| 國产一二三内射在线看片| 国产又爽又黄又不遮挡视频| 亚洲精品宾馆在线精品酒店| 97国产色伦在色在线播放| 97碰碰碰人妻无码视频 | 永久黄网站免费视频性色| 国内精品自线在拍2020不卡| 国产成人精品日本亚洲网站| 中文字幕aⅴ人妻一区二区| 人妻少妇-嫩草影院| 正在播放熟妇群老熟妇456| 无码丰满少妇2在线观看|