在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SPPL2B Antibody, Biotin conjugated

SPPL2B Antibody, Biotin conjugated

  • 中文名稱：
    SPPL2B兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA823457LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SPPL2B Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SPPL2B
  • 別名：
    SPPL2B antibody; IMP4 antibody; KIAA1532 antibody; PSL1 antibody; Signal peptide peptidase-like 2B antibody; SPP-like 2B antibody; SPPL2b antibody; EC 3.4.23.- antibody; Intramembrane protease 4 antibody; IMP-4 antibody; Presenilin homologous protein 4 antibody; PSH4 antibody; Presenilin-like protein 1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Signal peptide peptidase-like 2B protein (492-592AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity. Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis.
  • 基因功能參考文獻：
    1. TfR1 N-terminal fragment is a substrate for intramembrane proteolysis by SPPL2b. PMID: 23384347
    2. The alpha-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b). PMID: 22194595
    3. SPP, SPPL2a, -2b, -2c, and -3 probably cleave type II-oriented substrate peptides as shown by consensus analysis PMID: 15385547
    4. SPPL2b is targeted through the secretory pathway to endosomes/lysosomes, whereas SPP and SPPL3 are restricted to the ER. PMID: 15998642
    5. Results demonstrate that SPPL2b utilizes multiple intramembrane cleavages to liberate the intracellular domain of tumor necrosis factor alpha into the cytosol. PMID: 16829951
    6. SPPL2a and SPPL2b mediate the intramembrane cleavage, whereas neither SPP nor SPPL3 is capable of processing the Bri2 N-terminal fragment. PMID: 17965014
    7. Alzheimer disease-like mutant SPPL2b slowed intramembrane proteolysis of tumor necrosis factor alpha and caused a relative increase of longer intracellular cleavage products. PMID: 18768471

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein; Lumenal side.
  • 蛋白家族：
    Peptidase A22B family
  • 組織特異性：
    Expressed predominantly in adrenal cortex and mammary gland.
  • 數據庫鏈接：

    HGNC: 30627

    OMIM: 608239

    KEGG: hsa:56928

    UniGene: Hs.744026



主站蜘蛛池模板： 少妇内射高潮福利炮| 在线成人a毛片免费播放| 久爱无码精品免费视频在线观看| 东京热毛片无码dvd一二三区| 亚洲国产精品无码久久秋霞| 婷婷丁香六月激情综合啪| 日韩电影一区二区三区| 鲁大师影院在线观看| 日本高清无卡码一区二区久久| 97国产精品麻豆性色aⅴ人妻波| 国产av久久久久精东av| 国产福利永久在线视频无毒不卡 | 99热门精品一区二区三区无码| 国产日产欧产精品精品免费| 日本肉体裸xxxxbbbb| 性欧美大战久久久久久久| 久久久久久久久久久国产| 香蕉欧美成人精品a∨在线观看| 国产未成女一区二区| 国产一区二区三区不卡av| 50岁退休熟女露脸高潮| 亚洲欧美偷国产日韩| 欧美黑人激情性久久| 51国偷自产一区二区三区| 久久免费午夜福利院| 麻豆成人久久精品二区三区免费 | 国产精品亚洲专区无码破解版| 国产精品白丝喷水在线观看| 国产又色又爽无遮挡免费| 亚洲大色堂人在线无码| 2021最新国产精品网站| 色噜噜av男人的天堂| 人妻丝袜中文无码av影音先锋专区| 热99re久久精品国产首页免费| 131美女爱做视频国产福利| 亚洲人成网站在线观看69影院| 99久久国语露脸精品国产| 国产激情综合在线看| 丰满少妇呻吟高潮经历| 黑人玩弄出轨人妻松雪| 久久亚洲精品国产亚洲老地址|