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  4. SPPL2B Antibody, Biotin conjugated

SPPL2B Antibody, Biotin conjugated

  • 中文名稱：
    SPPL2B兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA823457LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SPPL2B Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SPPL2B
  • 別名：
    SPPL2B antibody; IMP4 antibody; KIAA1532 antibody; PSL1 antibody; Signal peptide peptidase-like 2B antibody; SPP-like 2B antibody; SPPL2b antibody; EC 3.4.23.- antibody; Intramembrane protease 4 antibody; IMP-4 antibody; Presenilin homologous protein 4 antibody; PSH4 antibody; Presenilin-like protein 1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Signal peptide peptidase-like 2B protein (492-592AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity. Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis.
  • 基因功能參考文獻：
    1. TfR1 N-terminal fragment is a substrate for intramembrane proteolysis by SPPL2b. PMID: 23384347
    2. The alpha-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b). PMID: 22194595
    3. SPP, SPPL2a, -2b, -2c, and -3 probably cleave type II-oriented substrate peptides as shown by consensus analysis PMID: 15385547
    4. SPPL2b is targeted through the secretory pathway to endosomes/lysosomes, whereas SPP and SPPL3 are restricted to the ER. PMID: 15998642
    5. Results demonstrate that SPPL2b utilizes multiple intramembrane cleavages to liberate the intracellular domain of tumor necrosis factor alpha into the cytosol. PMID: 16829951
    6. SPPL2a and SPPL2b mediate the intramembrane cleavage, whereas neither SPP nor SPPL3 is capable of processing the Bri2 N-terminal fragment. PMID: 17965014
    7. Alzheimer disease-like mutant SPPL2b slowed intramembrane proteolysis of tumor necrosis factor alpha and caused a relative increase of longer intracellular cleavage products. PMID: 18768471

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein; Lumenal side.
  • 蛋白家族：
    Peptidase A22B family
  • 組織特異性：
    Expressed predominantly in adrenal cortex and mammary gland.
  • 數據庫鏈接：

    HGNC: 30627

    OMIM: 608239

    KEGG: hsa:56928

    UniGene: Hs.744026



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