在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Serpin B4 (SERPINB4)

Recombinant Human Serpin B4 (SERPINB4)

  • 中文名稱：
    人SERPINB4重組蛋白
  • 貨號：
    CSB-YP021072HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SERPINB4重組蛋白
  • 貨號：
    CSB-EP021072HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SERPINB4重組蛋白
  • 貨號：
    CSB-BP021072HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SERPINB4重組蛋白
  • 貨號：
    CSB-MP021072HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SERPINB4
  • Uniprot No.：
  • 別名：
    Leupin; Peptidase inhibitor 11; PI 11; PI-11; PI11; Protease inhibitor (leucine serpin); SCCA 2; SCCA-2; SCCA1; SCCA2; SCCA2/SCCA1 fusion protein; Serine (or cysteine) proteinase inhibitor; clade B (ovalbumin); member 4; Serpin B4; Serpin peptidase inhibitor; clade B (ovalbumin); member 4; SERPINB 4; SERPINB4; SPB4_HUMAN; Squamous cell carcinoma antigen 1; Squamous cell carcinoma antigen 2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達(dá)區(qū)域：
    1-390
  • 氨基酸序列
    MNSLSEANTK FMFDLFQQFR KSKENNIFYS PISITSALGM VLLGAKDNTA QQISKVLHFD QVTENTTEKA ATYHVDRSGN VHHQFQKLLT EFNKSTDAYE LKIANKLFGE KTYQFLQEYL DAIKKFYQTS VESTDFANAP EESRKKINSW VESQTNEKIK NLFPDGTIGN DTTLVLVNAI YFKGQWENKF KKENTKEEKF WPNKNTYKSV QMMRQYNSFN FALLEDVQAK VLEIPYKGKD LSMIVLLPNE IDGLQKLEEK LTAEKLMEWT SLQNMRETCV DLHLPRFKME ESYDLKDTLR TMGMVNIFNG DADLSGMTWS HGLSVSKVLH KAFVEVTEEG VEAAAATAVV VVELSSPSTN EEFCCNHPFL FFIRQNKTNS ILFYGRFSSP
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    May act as a protease inhibitor to modulate the host immune response against tumor cells.
  • 基因功能參考文獻(xiàn)：
    1. The combination of SCCA-IgM with common clinical data shows promising diagnostic performance for the detection of Non-alcoholic steato-hepatitis in hepatitis C virus patients PMID: 29712495
    2. Both periostin and SCCA may play a role in the pathogenesis of acute bronchitis due to respiratory syncytial virus PMID: 29122495
    3. Serum SCCA2 levels reflected disease severity and clinical type of atopic dermatitis. Serum SCCA2 may thus be a relevant biomarker for atopic dermatitis. PMID: 28734739
    4. Data show that oropharyngeal squamous cell carcinomas (OPSCCs) express granzyme inhibitors SERPINB1, SERPINB4 and SERPINB9 for cytotoxicity and the expression was not different between human papillomavirus (HPV)-positive and HPV-negative tumors. PMID: 26993499
    5. Pediatric CNS-PNETs evade immune recognition by downregulating cell surface MHC-I and CD1d expression. Intriguingly, expression of SERPINB9, SERPINB1, and SERPINB4 is acquired during tumorigenesis in 29%, 29%, and 57% of the tumors PMID: 26963506
    6. It is a promising serological marker for hepatocellular carcinoma. PMID: 24635038
    7. our findings established that SCCA1 contributes to tumorigenesis by promoting EMT and a UPR-dependent induction of NF-kappaB and IL6 autocrine signaling that promotes a protumorigenic inflammation. PMID: 25213322
    8. demonstrate the generation of Pso p27 from SCCA1 with extracts from psoriatic scale and even more remarkably, the generation of Pso p27 from SCCA1 in the presence of mast cell associated chymase PMID: 24560885
    9. The results show that SCCA1 has diverse effects on many of the cellular events that characterize asthma and its role extends beyond protease inhibition. PMID: 23199842
    10. The serum level of SCCA is effective for detecting inverted papilloma (IP), including recurrent IP. In contrast, the SCCA2/SCCA1 ratio is useful for detecting squamous cell carcinoma among other sinonasal diseases. PMID: 23168150
    11. High serum SCCA1 levels are associated with lymph node metastasis, advanced tumor stage and tumor recurrence in oral cavity squamous cell carcinoma. PMID: 22576068
    12. both HPV status and the SCCA2/SCCA1 mRNA ratio are independently associated with prognosis in HNSCC PMID: 22937809
    13. Serpin B4 isoform overexpression is associated with aberrant epithelial proliferation and lung cancer in idiopathic pulmonary fibrosis. PMID: 22406480
    14. Results indicate that cellular overexpression of SERPINB4 inhibits recombinant GrM-induced as well as NK cell-mediated cell death. PMID: 21857942
    15. Data suggest that SCCA1 inhibits cell death induced by lysosomal injury while, on the other hand, it sensitizes cells to ER stress by activating caspase-8 independently of the death receptor apoptotic pathway. PMID: 21576355
    16. Elevated serum SCCA1 is associated with squamous cell carcinoma in cervical cancer. PMID: 21338226
    17. Transgenic mice expressing human SCCA1 showed higher liver regenerative potential compared to wild-type mice, supporting the dual role of this serpin as an anti-apoptotic and pro-proliferative stimulus for liver cells in vivo. PMID: 19956912
    18. expression in various normal tissue types and in tumor cell lines, increase in expression induced by TNF-alpha, and role in protecting tumor cells against TNF-alpha induced apoptsis PMID: 12437110
    19. SCCA2-like serpins mediate genetic predisposition to skin cancer in a mouse model and in humans. PMID: 12702576
    20. SCCA2 acts as a cross-class serpin targeting an extrinsic cysteine proteinase from mites and may have a protective role against biological reactions caused by mites PMID: 14630915
    21. SCCA variants are overexpressed in hepatocellular carcinoma independently of tumour etiology PMID: 14970861
    22. SCCAs can alter invasive phenotype of cervical squamous cell carcinoma cells, probably by stimulating proMMP-9 production, and intact conformational structure of SCCAs is required for its stimulatory activity on proMMP-9 production PMID: 16211231
    23. Up-regulation of squamous cell carcinoma antigen-1 (SCCA1) suppresses c-Jun NH2-terminal kinase-1 (JNK1) and thus blocks UV-induced keratinocyte apoptosis. PMID: 16549498
    24. These results, in transgenic mice, suggest that SCAA1 might serve as an hepatitis B virus receptor or co-receptor and play an important role in mediating HBV entry into hepatocytes. PMID: 16820864
    25. SCCA2 regulates cell migration and invasion via E-cadherin expression, suggesting that SCCA2 may be involved in cancer behavior such as invasion or metastasis. PMID: 17016656
    26. SCCA2 may be involved in cancer behavior such as metastasis, and as such can be a useful marker in predicting lymph node metastasis. PMID: 18097581
    27. fatty acid-binding protein-5, squamous cell carcinoma antigens 2, alpha-enolase, annexin II, apolipoprotein A-I and albumin were detected at a high level in Atopic dermatitis skin lesions, but scarcely in the normal controls PMID: 19339807

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Note=Seems to also be secreted in plasma by cancerous cells but at a low level.
  • 蛋白家族：
    Serpin family, Ov-serpin subfamily
  • 組織特異性：
    Squamous cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10570

    OMIM: 600518

    KEGG: hsa:6318

    STRING: 9606.ENSP00000343445

    UniGene: Hs.123035



主站蜘蛛池模板： 男女猛烈xx00免费视频试看| 日本xxxx丰满老妇| 精品国产电影久久九九| 一本色道久久99一综合| 欧美黑人添添高潮a片www| 国产又黄又刺激又高潮的网站| 久久99国产综合精品女同| 中文字幕精品av乱码在线| 亚洲日韩欧美国产高清αv| 国产免费丝袜调教视频| 亚洲国产激情一区二区三区| 国产 中文 制服丝袜 另类| 成人精品一区日本无码网| 少妇被粗大的猛进69视频| 精品系列无码一区二区三区| 欧美人禽zozo动人物杂交| 夫妇交换性三中文字幕| 国产精品无码素人福利| 国产片a国产片免费看视频| 在线观看特色大片免费视频 | 成人性无码专区免费视频| 亚洲综合av一区二区三区| 欧美在线看片a免费观看| 亚洲色婷婷婷婷五月基地 | 天堂中文官网在线| 成在人线av无码免费| 亚洲成年网站青青草原| 国产深夜福利视频在线 | 国产精品一线二线三线| 免费无码a片一区二三区| 国产69精品久久久久孕妇| 人妻人人做人碰人人添| 欧美破苞系列二十三| 免费乱理伦片在线观看| 亚洲伊人久久大香线蕉av| 级r片内射在线视频播放| 色欲av巨乳无码一区二区| 无码伊人66久久大杳蕉网站谷歌 | 亚洲卡一卡二乱码新区仙踪| 国产男女猛烈无遮挡免费网站 | 亚洲欧洲国产成人综合在线观看|