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Human Squamous Cell Carcinoma Antigen 2,SCCAg 2 ELISA Kit

  • 中文名稱:
    人鱗狀上皮細胞癌抗原2(SCCAg-2)酶聯免疫試劑盒
  • 貨號:
    CSB-E04776h
  • 規格:
    96T/48T
  • 價格:
    ¥3200/¥2500
  • 其他:

產品詳情

  • 產品描述:
    人鱗狀上皮細胞癌抗原2(SCCAg-2)酶聯免疫試劑盒(CSB-E04776h)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿樣本中的SERPINB4含量。SERPINB4 作為一個重要靶點,它屬于絲氨酸蛋白酶抑制劑家族成員。在人體中,其表達異常與多種疾病發生發展相關。研究機制方面,主要聚焦于它對相關蛋白酶活性的調控,以及在細胞增殖、凋亡和腫瘤轉移等過程中發揮的作用。試劑盒檢測范圍為0.312 ng/ml-20 ng/ml,科研人員可將其應用于腫瘤模型構建、抗癌藥物療效評估或癌癥分子機制研究,特別適用于鱗狀上皮來源的腫瘤細胞系或動物模型中SCCAg - 2表達水平的縱向監測,為探索腫瘤微環境調控及靶向治療提供可靠數據支持。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    Leupin ELISA Kit; Peptidase inhibitor 11 ELISA Kit; PI 11 ELISA Kit; PI-11 ELISA Kit; PI11 ELISA Kit; Protease inhibitor (leucine serpin) ELISA Kit; SCCA 2 ELISA Kit; SCCA-2 ELISA Kit; SCCA1 ELISA Kit; SCCA2 ELISA Kit; SCCA2/SCCA1 fusion protein ELISA Kit; Serine (or cysteine) proteinase inhibitor; clade B (ovalbumin); member 4 ELISA Kit; Serpin B4 ELISA Kit; Serpin peptidase inhibitor; clade B (ovalbumin); member 4 ELISA Kit; SERPINB 4 ELISA Kit; SERPINB4 ELISA Kit; SPB4_HUMAN ELISA Kit; Squamous cell carcinoma antigen 1 ELISA Kit; Squamous cell carcinoma antigen 2 ELISA Kit
  • 縮寫:
    SERPINB4
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 樣本類型:
    serum, plasma
  • 檢測范圍:
    0.312 ng/ml-20 ng/ml
  • 靈敏度:
    0.078 ng/ml
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Cell Biology
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 數據處理:
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 功能:
    May act as a protease inhibitor to modulate the host immune response against tumor cells.
  • 基因功能參考文獻:
    1. The combination of SCCA-IgM with common clinical data shows promising diagnostic performance for the detection of Non-alcoholic steato-hepatitis in hepatitis C virus patients PMID: 29712495
    2. Both periostin and SCCA may play a role in the pathogenesis of acute bronchitis due to respiratory syncytial virus PMID: 29122495
    3. Serum SCCA2 levels reflected disease severity and clinical type of atopic dermatitis. Serum SCCA2 may thus be a relevant biomarker for atopic dermatitis. PMID: 28734739
    4. Data show that oropharyngeal squamous cell carcinomas (OPSCCs) express granzyme inhibitors SERPINB1, SERPINB4 and SERPINB9 for cytotoxicity and the expression was not different between human papillomavirus (HPV)-positive and HPV-negative tumors. PMID: 26993499
    5. Pediatric CNS-PNETs evade immune recognition by downregulating cell surface MHC-I and CD1d expression. Intriguingly, expression of SERPINB9, SERPINB1, and SERPINB4 is acquired during tumorigenesis in 29%, 29%, and 57% of the tumors PMID: 26963506
    6. It is a promising serological marker for hepatocellular carcinoma. PMID: 24635038
    7. our findings established that SCCA1 contributes to tumorigenesis by promoting EMT and a UPR-dependent induction of NF-kappaB and IL6 autocrine signaling that promotes a protumorigenic inflammation. PMID: 25213322
    8. demonstrate the generation of Pso p27 from SCCA1 with extracts from psoriatic scale and even more remarkably, the generation of Pso p27 from SCCA1 in the presence of mast cell associated chymase PMID: 24560885
    9. The results show that SCCA1 has diverse effects on many of the cellular events that characterize asthma and its role extends beyond protease inhibition. PMID: 23199842
    10. The serum level of SCCA is effective for detecting inverted papilloma (IP), including recurrent IP. In contrast, the SCCA2/SCCA1 ratio is useful for detecting squamous cell carcinoma among other sinonasal diseases. PMID: 23168150
    11. High serum SCCA1 levels are associated with lymph node metastasis, advanced tumor stage and tumor recurrence in oral cavity squamous cell carcinoma. PMID: 22576068
    12. both HPV status and the SCCA2/SCCA1 mRNA ratio are independently associated with prognosis in HNSCC PMID: 22937809
    13. Serpin B4 isoform overexpression is associated with aberrant epithelial proliferation and lung cancer in idiopathic pulmonary fibrosis. PMID: 22406480
    14. Results indicate that cellular overexpression of SERPINB4 inhibits recombinant GrM-induced as well as NK cell-mediated cell death. PMID: 21857942
    15. Data suggest that SCCA1 inhibits cell death induced by lysosomal injury while, on the other hand, it sensitizes cells to ER stress by activating caspase-8 independently of the death receptor apoptotic pathway. PMID: 21576355
    16. Elevated serum SCCA1 is associated with squamous cell carcinoma in cervical cancer. PMID: 21338226
    17. Transgenic mice expressing human SCCA1 showed higher liver regenerative potential compared to wild-type mice, supporting the dual role of this serpin as an anti-apoptotic and pro-proliferative stimulus for liver cells in vivo. PMID: 19956912
    18. expression in various normal tissue types and in tumor cell lines, increase in expression induced by TNF-alpha, and role in protecting tumor cells against TNF-alpha induced apoptsis PMID: 12437110
    19. SCCA2-like serpins mediate genetic predisposition to skin cancer in a mouse model and in humans. PMID: 12702576
    20. SCCA2 acts as a cross-class serpin targeting an extrinsic cysteine proteinase from mites and may have a protective role against biological reactions caused by mites PMID: 14630915
    21. SCCA variants are overexpressed in hepatocellular carcinoma independently of tumour etiology PMID: 14970861
    22. SCCAs can alter invasive phenotype of cervical squamous cell carcinoma cells, probably by stimulating proMMP-9 production, and intact conformational structure of SCCAs is required for its stimulatory activity on proMMP-9 production PMID: 16211231
    23. Up-regulation of squamous cell carcinoma antigen-1 (SCCA1) suppresses c-Jun NH2-terminal kinase-1 (JNK1) and thus blocks UV-induced keratinocyte apoptosis. PMID: 16549498
    24. These results, in transgenic mice, suggest that SCAA1 might serve as an hepatitis B virus receptor or co-receptor and play an important role in mediating HBV entry into hepatocytes. PMID: 16820864
    25. SCCA2 regulates cell migration and invasion via E-cadherin expression, suggesting that SCCA2 may be involved in cancer behavior such as invasion or metastasis. PMID: 17016656
    26. SCCA2 may be involved in cancer behavior such as metastasis, and as such can be a useful marker in predicting lymph node metastasis. PMID: 18097581
    27. fatty acid-binding protein-5, squamous cell carcinoma antigens 2, alpha-enolase, annexin II, apolipoprotein A-I and albumin were detected at a high level in Atopic dermatitis skin lesions, but scarcely in the normal controls PMID: 19339807

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  • 亞細胞定位:
    Cytoplasm. Note=Seems to also be secreted in plasma by cancerous cells but at a low level.
  • 蛋白家族:
    Serpin family, Ov-serpin subfamily
  • 組織特異性:
    Squamous cells.
  • 數據庫鏈接:

    HGNC: 10570

    OMIM: 600518

    KEGG: hsa:6318

    STRING: 9606.ENSP00000343445

    UniGene: Hs.123035



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