在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Serine/threonine-protein phosphatase PGAM5,mitochondrial (PGAM5), partial

  • 中文名稱:
    人PGAM5重組蛋白
  • 貨號:
    CSB-EP839338HU
  • 規(guī)格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
  • Uniprot No.:
  • 別名:
    Bcl-XL-binding protein v68;Phosphoglycerate mutase family member 5
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    56.8 kDa
  • 表達區(qū)域:
    30-289aa
  • 氨基酸序列
    KPRAGGDAEPRPAEPPAWAGGARPGPGVWDPNWDRREPLSLINVRKRNVESGEEELASKLDHYKAKATRHIFLIRHSQYHVDGSLEKDRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIISRHLPGVCKVSTDLLREGAPIEPDPPVSHWKPEAVQYYEDGARIEAAFRNYIHRADARQEEDSYEIFICHANVIRYIVCRALQFPPEGWLRLSLNNGSITHLVIRPNGRVALRTLGDTGFMPPDKITRS
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal GST-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore.
  • 基因功能參考文獻:
    1. An intact complex of PGAM5-KEAP1-Nrf2 preserves mitochondrial motility by suppressing dominant-negative KEAP1 activity. PMID: 28839075
    2. PGAM5 regulates histidine phosphorylation to control TCR activation of CD4-positive T cells. PMID: 27453048
    3. Results indicate that a multiprotein complex including PGAM5, Bax and Drp1 proteins specifically formed during intrinsic apoptosis induction. PMID: 26356820
    4. Results identify a crucial role for RIPK3-PGAM5-Drp1/NFAT signalling in NKT cell activation, and further suggest that RIPK3-PGAM5 signalling may mediate crosstalk between mitochondrial function and immune signalling. PMID: 26381214
    5. Dephosphorylation of FUNDC1 by PGAM5 induces mitophagy. PMID: 24746696
    6. PGAM5 is proteolytically processed, accumulates in the cytosol during apoptosis, and sensitizes cells to death. PMID: 23201124
    7. Experimental data indicate that the two splice variants of the mitochondrial protein phosphatase PGAM5 are at the convergent point of multiple necrosis pathways. PMID: 22265414
    8. The N terminus of the PGAM5 protein contains a conserved NXESGE motif that binds to the substrate binding pocket in the Kelch domain of Keap1. PMID: 17046835
    9. Results suggest that this member of the PGAM family has crossed over from small molecules to protein substrates and been adapted to serve as a specialized activator of ASK1. PMID: 19590015

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion outer membrane; Single-pass membrane protein. Note=Isoform 2 overexpression results in the formation of disconnected punctuate mitochondria distributed throughout the cytoplasm. Isoform 1 overexpression results in the clustering of mitochondria around the nucleus.
  • 蛋白家族:
    Phosphoglycerate mutase family, BPG-dependent PGAM subfamily
  • 數(shù)據(jù)庫鏈接:

    HGNC: 28763

    OMIM: 614939

    KEGG: hsa:192111

    STRING: 9606.ENSP00000438465

    UniGene: Hs.102558



主站蜘蛛池模板: 国产成人精品成人a在线观看| 久久精品亚洲精品无码| 精品亚洲国产成人av在线小说 | 欧洲熟妇色xxxx欧美老妇多毛| 午夜dv内射一区区| 亚洲欧美精品suv| 女人高潮抽搐潮喷视频开腿| 99精品全国免费观看视频| 无码人妻一区二区三区免费手机| 日日橹狠狠爱欧美超碰 | 亚洲最新无码成av人| 黑人强伦姧人妻久久| 小13箩利洗澡无码视频网站| 色鬼7777久久| 国产亚洲精品久久久久久小舞| 国产精品久久久久久tv| 色诱视频在线观看| 欧美人妻aⅴ中文字幕| 熟女丰满老熟女熟妇| 天天看片天天av免费观看| 99精品国产高清一区二区麻豆| 色诱视频在线观看| 一区二区三区人妻无码| 欧美激情一区二区成人| 人妻无码熟妇乱又伦精品视频| 亚洲毛片αv无线播放一区 | 久久久久久无码精品人妻a片软件 999久久久精品国产消防器材 | 天天躁日日躁狠狠躁av中文| 99久久综合狠狠综合久久| 国产老熟女老女人老人| 国产女人叫床高潮大片| 手机福利视频| 国产性猛交╳xxx乱大交| 久久亚洲精品成人无码网站夜色| 大胆日本熟妇xxxx| 麻豆亚洲一区| 真人做受试看120分钟小视频| 男女啪啦啦超猛烈动态图| 国产午夜福利短视频| 欧美熟妇性开放| 中文人妻av大区中文不卡|