在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Serine/threonine-protein phosphatase PGAM5,mitochondrial (PGAM5), partial

  • 中文名稱:
    人PGAM5重組蛋白
  • 貨號:
    CSB-EP839338HU
  • 規(guī)格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
  • Uniprot No.:
  • 別名:
    Bcl-XL-binding protein v68;Phosphoglycerate mutase family member 5
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    56.8 kDa
  • 表達區(qū)域:
    30-289aa
  • 氨基酸序列
    KPRAGGDAEPRPAEPPAWAGGARPGPGVWDPNWDRREPLSLINVRKRNVESGEEELASKLDHYKAKATRHIFLIRHSQYHVDGSLEKDRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIISRHLPGVCKVSTDLLREGAPIEPDPPVSHWKPEAVQYYEDGARIEAAFRNYIHRADARQEEDSYEIFICHANVIRYIVCRALQFPPEGWLRLSLNNGSITHLVIRPNGRVALRTLGDTGFMPPDKITRS
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal GST-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore.
  • 基因功能參考文獻:
    1. An intact complex of PGAM5-KEAP1-Nrf2 preserves mitochondrial motility by suppressing dominant-negative KEAP1 activity. PMID: 28839075
    2. PGAM5 regulates histidine phosphorylation to control TCR activation of CD4-positive T cells. PMID: 27453048
    3. Results indicate that a multiprotein complex including PGAM5, Bax and Drp1 proteins specifically formed during intrinsic apoptosis induction. PMID: 26356820
    4. Results identify a crucial role for RIPK3-PGAM5-Drp1/NFAT signalling in NKT cell activation, and further suggest that RIPK3-PGAM5 signalling may mediate crosstalk between mitochondrial function and immune signalling. PMID: 26381214
    5. Dephosphorylation of FUNDC1 by PGAM5 induces mitophagy. PMID: 24746696
    6. PGAM5 is proteolytically processed, accumulates in the cytosol during apoptosis, and sensitizes cells to death. PMID: 23201124
    7. Experimental data indicate that the two splice variants of the mitochondrial protein phosphatase PGAM5 are at the convergent point of multiple necrosis pathways. PMID: 22265414
    8. The N terminus of the PGAM5 protein contains a conserved NXESGE motif that binds to the substrate binding pocket in the Kelch domain of Keap1. PMID: 17046835
    9. Results suggest that this member of the PGAM family has crossed over from small molecules to protein substrates and been adapted to serve as a specialized activator of ASK1. PMID: 19590015

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion outer membrane; Single-pass membrane protein. Note=Isoform 2 overexpression results in the formation of disconnected punctuate mitochondria distributed throughout the cytoplasm. Isoform 1 overexpression results in the clustering of mitochondria around the nucleus.
  • 蛋白家族:
    Phosphoglycerate mutase family, BPG-dependent PGAM subfamily
  • 數(shù)據(jù)庫鏈接:

    HGNC: 28763

    OMIM: 614939

    KEGG: hsa:192111

    STRING: 9606.ENSP00000438465

    UniGene: Hs.102558



主站蜘蛛池模板: 大香线蕉伊人超碰| 18禁男女爽爽爽午夜网站免费| 无码人妻丰满熟妇啪啪网站| 亚洲欧美综合中文| 国产日韩精品视频无码| 精品久久久无码中文字幕天天| 精品一区二区三区无码视频| 亚洲最大成人综合网720p| 亚洲国产精品av在线播放| 久久久无码精品亚洲日韩啪啪网站| 日韩 欧美 动漫 国产 制服| 人妻精品国产一区二区| 国产精品亚洲玖玖玖在线观看 | 97视频热人人精品免费| 亚洲国产桃花岛一区二区| 九九视频免费精品视频| 人与禽交videos欧美| 丰满岳乱妇在线观看中字| 秋霞国产精品一区二区| 思思久久99热只有频精品66| 女人爽得直叫免费视频| 欧美片内射欧美美美妇| 亚洲中国精品精华液| 精品国产一区二区三区av性色| 久久精品人人槡人妻人| 久久www成人片免费看| 亚洲国产精品尤物yw在线观看| 最大胆裸体人体牲交| 久久97久久97精品免视看秋霞| 日本动漫瀑乳h动漫啪啪免费| 国产午夜毛片v一区二区三区| 久久er热在这里只有精品66| 成人免费网站视频www| 国产精品国产三级国快看| 少女韩国电视剧在线观看完整| 国产桃色无码视频在线观看 | 国产成人毛片在线视频软件| 最近更新中文字幕免费大全| 无码乱人伦一区二区亚洲一| 国产真实自在自线免费精品| 国内久久婷婷六月综合欲色啪|