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  4. Recombinant Human Serine/threonine-protein kinase Nek1 (NEK1), partial

Recombinant Human Serine/threonine-protein kinase Nek1 (NEK1), partial

  • 中文名稱：
    人NEK1重組蛋白
  • 貨號：
    CSB-YP836281HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人NEK1重組蛋白
  • 貨號：
    CSB-EP836281HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人NEK1重組蛋白
  • 貨號：
    CSB-EP836281HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人NEK1重組蛋白
  • 貨號：
    CSB-BP836281HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人NEK1重組蛋白
  • 貨號：
    CSB-MP836281HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    NEK1
  • Uniprot No.：
  • 別名：
    DKFZp686D06121; DKFZp686K12169; kat; KIAA1901; MGC138800; MGC189817; NEK1; NEK1_HUMAN; Never in mitosis A-related kinase 1; Never in mitosis gene A-related kinase 1; NIMA (never in mitosis gene a)-related kinase 1; NIMA-related kinase 1; NimA-related protein kinase 1; NY-REN-55; OTTHUMP00000219432; OTTHUMP00000219433; OTTHUMP00000219434; OTTHUMP00000219435; Protein-serine/threonine kinase; Renal carcinoma antigen NY-REN-55; Serine/threonine-protein kinase Nek1; SRPS2; SRPS2A; SRTD6
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Involved in DNA damage checkpoint control and for proper DNA damage repair. In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death. May be implicated in the control of meiosis. Involved in cilium assembly.
  • 基因功能參考文獻：
    1. We provide novel evidence for association of NEK1 with ALS in Chinese, reporting variants in these genes not previously found in Europeans. PMID: 29149916
    2. NEK1 variants may modify disease presentation of driving mutations. PMID: 28935222
    3. Following DNA damage, addition of the TLK1 inhibitor, THD, or overexpression of NEK1-T141A mutant impaired ATR and Chk1 activation, indicating the existence of a TLK1>NEK1>ATR>Chk1 pathway. Indeed, overexpression of the NEK1-T141A mutant resulted in an altered cell cycle response after exposure of cells to oxidative stress, including bypass of G1 arrest and implementation of an intra S-phase checkpoint. PMID: 28426283
    4. This study shown that the NEK1 is a novel in patient with familial amyotrophic lateral sclerosis. PMID: 26945885
    5. Mutation in NEK1 gene is associated with amyotrophic lateral sclerosis. PMID: 27455347
    6. Nek1 phosphorylates Rad54 and regulates Rad51 removal to orchestrate homologous recombination and replication fork stability. PMID: 27264870
    7. Compound heterozygous variants in NEK1 were identified in two brothers with Mohr syndrome. The nonsense variant c.1226G>A, p.(Trp409*), results in nonsense-associated alternative splicing. Ciliation in patient fibroblasts is drastically reduced. PMID: 27530628
    8. The skeletal phenotype of our patient was milder than those of previously reported cases with NEK1 mutations and those with axial SMD harboring C21orf2 mutations. Phenotypes associated with NEK1 mutations are variable and the phenotype-genotype corelation in skeletal ciliopathies is challenging PMID: 28123176
    9. Nek1 overexpression in gliomas was correlated with the proliferation marker (Ki-67), tumor grade, Karnofsky performance scale (KPS) and more importantly, patients' poor survival. Further studies showed that Nek1 expression level was also increased in multiple glioma cell lines (U251-MG, U87-MG, U118, H4 and U373). PMID: 27251576
    10. C21ORF2 functions in the same pathway as NEK1 in DNA damage repair. PMID: 26290490
    11. Nek1 may facilitate S-phase progression by interacting with Ku80 and regulating chromatin loading of replication factors. PMID: 23851348
    12. Nek1 may suppress cilia by phosphorylating pVHL, which is critical to microtubule stabilization and ciliary stability. PMID: 23255108
    13. as an ATR-associated kinase, Nek1 enhances the stability and activity of ATR-ATRIP before DNA damage, priming ATR-ATRIP for a robust DNA damage response PMID: 23345434
    14. The present case provides evidence for a correlation of NEK1 mutation with short rib-polydactyly syndrome type II (Majewski. PMID: 22482978
    15. This study confirms that NEK1 is one gene causing SRP type II but also reports mutations in DYNC2H1, expanding the phenotypic spectrum of DYNC2H1 mutations. PMID: 22499340
    16. results demonstrate that Nek1 is important for proper checkpoint control and characterize for the first time a DNA damage response that does not directly involve one of the known upstream mediator kinases, ATM or ATR PMID: 21301226
    17. absence of functional full-length NEK1 severely reduces cilia number and alters ciliar morphology in vivo. PMID: 21211617
    18. Nek1 is involved in the beginning of the cellular response to genotoxic stress and plays an important role in preventing cell death induced by DNA damage. PMID: 20501547
    19. Data report that NEK1 and CLASP2 colocalize with FEZ1 in a perinuclear region in mammalian cells, and observed that coiled-coil interactions occur between FEZ1/CLASP2 and FEZ1/NEK1 in vitro. PMID: 19924516
    20. these data provide a mechanism to explain how Nek1 regulates cell death by affecting the opening and closing of VDAC1. PMID: 20230784
    21. Mapping studies of NEK1 regulatory domain indicate interaction with most of the proteins known to take part in etiology of polycystic kidney disease, in double-strand DNA break repair at the G2/M cell-cycle transition phase, or in neural cell development. PMID: 14690447
    22. Nek1 may function as a kinase early in the DNA damage response pathway. PMID: 15604234
    23. These data show that Nek1 is important for efficient DNA damage checkpoint control and for proper DNA damage repair. PMID: 18843199

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  • 相關疾病：
    Short-rib thoracic dysplasia 6 with or without polydactyly (SRTD6)
  • 亞細胞定位：
    Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm.
  • 蛋白家族：
    Protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily
  • 組織特異性：
    High fetal expression in the brain and kidney.
  • 數據庫鏈接：

    HGNC: 7744

    OMIM: 263520

    KEGG: hsa:4750

    STRING: 9606.ENSP00000424757

    UniGene: Hs.481181



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