在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Serine racemase (SRR)

Recombinant Human Serine racemase (SRR)

  • 中文名稱：
    人SRR重組蛋白
  • 貨號：
    CSB-YP022691HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SRR重組蛋白
  • 貨號：
    CSB-EP022691HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SRR重組蛋白
  • 貨號：
    CSB-BP022691HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SRR重組蛋白
  • 貨號：
    CSB-MP022691HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SRR
  • Uniprot No.：
  • 別名：
    D serine ammonia lyase; D serine dehydratase; D-serine ammonia-lyase; D-serine dehydratase; ILV1; ISO1; L serine ammonia lyase; L serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase; Serine racemase; srr; SRR_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-340
  • 氨基酸序列
    MCAQYCISFA DVEKAHINIR DSIHLTPVLT SSILNQLTGR NLFFKCELFQ KTGSFKIRGA LNAVRSLVPD ALERKPKAVV THSSGNHGQA LTYAAKLEGI PAYIVVPQTA PDCKKLAIQA YGASIVYCEP SDESRENVAK RVTEETEGIM VHPNQEPAVI AGQGTIALEV LNQVPLVDAL VVPVGGGGML AGIAITVKAL KPSVKVYAAE PSNADDCYQS KLKGKLMPNL YPPETIADGV KSSIGLNTWP IIRDLVDDIF TVTEDEIKCA TQLVWERMKL LIEPTAGVGV AAVLSQHFQT VSPEVKNICI VLSGGNVDLT SSITWVKQAE RPASYQSVSV
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.
  • 基因功能參考文獻：
    1. SRR was identified as a type 2 diabetes susceptibility gene. SRR plays a role in insulin secretion in vitro. PMID: 28580277
    2. rs391300 SNP, located on the serine racemase (SRR) gene and linked to increased susceptibility to type 2 diabetes, was associated with progression from mild cognitive impairment to probable Alzheimer's disease. PMID: 29338921
    3. Study found an inverse association between the genetic risk off schizophrenia based on 108 genome-wide significantly associated SNPs and the prevalence for treated migraine in a general population sample. This association was primary linked to SNPs associated with genes encoding proteins involved in glutamatergic neurotransmission and could be attributed to the single intronic variant rs4523957 in SRR. PMID: 27394076
    4. Data suggest that Ser-84 and Arg-135 are important in catalysis and substrate specificity of SRR. PMID: 28696262
    5. Magnesium and calcium ions differentially affect human serine racemase activity and modulate its quaternary equilibrium toward a tetrameric form PMID: 28089597
    6. MiR-193a-3p and miR-193a-5p play important roles in osteosarcoma metastasis through down-regulation of the Rab27B and SRR genes and therefore may serve as useful biomarkers for the diagnosis of osteosarcoma PMID: 26913720
    7. Loss-of-function mutation of the gene encoding serine racemase significantly attenuates excitotoxicity in retina. PMID: 26485193
    8. Serine racemase activity and dynamics are regulated by halides, ATP and malonate. PMID: 25331425
    9. In serine racemase, similarly to the related enzyme alanine racemase, the unprotonated pyridoxal-5'-phosphate -substrate intermediate is stabilized mostly due to solvation effects contributed by water molecules and active-site residues. PMID: 25493718
    10. FBXO22 protein is required for optimal synthesis of NMDA receptor coagonist D-serine by interacting with serine racemase, activating it, and preventing its targeting to membranes. PMID: 25336657
    11. cross-talk between allosteric and active sites, leading to the stabilization of two alternative protein conformations with ATP affinities of ~ 10 muM and 1.8 mm PMID: 23992455
    12. S84A serine racemase mutant behaved like serine dehydratase, whereas A65S serine dehydratase mutant acquired an additional function of using D-serine as a substrate. PMID: 23112234
    13. The structural characteristics of SR obtained from live cells suggest that SR is sensitive to oxidation in vivo, perhaps consistent with a scenario in which such modification plays a role in feedback or other forms of regulation. PMID: 22151352
    14. Serine racemase and D-serine are involved in both pre-symptomatic and progressive phases of amyotrophic lateral sclerosis, demonstrating a link between mutant superoxide dismutase (SOD)1 and a glial-derived toxic mediator in transgenic mice. PMID: 22117694
    15. The SRR mRNA is elevated in people death with suicide. PMID: 20385472
    16. The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding PMID: 20106978
    17. Data report on the isolation of a cDNA encoding a human serine racemase (SRR) from a human neuronal like cell line. PMID: 15193426
    18. D-serine is synthesized in human placenta by the racemization of L-serine by serine racemase. PMID: 15219883
    19. serine racemase catalyzes the degradation of cellular D-serine itself, through the alpha,beta-elimination of water PMID: 15536068
    20. The frequency of the genotypes showed that 5'-G/C serine racemase is not a major risk factor for schizophrenia. PMID: 16446740
    21. Expression of serine racemaseusing Western blot analysis in postmortem hippocampus and cortex in schizophrenia and a comparison group. PMID: 16837850
    22. Not associated with schizophrenia in a Gefman case-control study. PMID: 17413455
    23. Not associated with bipolar disorder in a German case-control study. PMID: 17413456
    24. observed activation of serine racemase by divalent cations has been assumed to be a side-effect associated with ATP binding, which is known to form a complex with Mg(2+) ions PMID: 17697119
    25. serine racemase and D-amino acid oxidase are expressed in human brain and demonstrate aberrant D-serine metabolism in schizophrenia PMID: 17880399
    26. Analysis of SRR genetic variants in humans identified a robust association with schizophrenia. PMID: 19483194

    顯示更多

    收起更多

  • 蛋白家族：
    Serine/threonine dehydratase family
  • 組織特異性：
    Brain: expressed at high levels in hippocampus and corpus callosum, intermediate levels in substantia nigra and caudate, and low levels in amygdala, thalamus, and subthalamic nuclei. Expressed in heart, skeletal muscle, kidney and liver.
  • 數據庫鏈接：

    HGNC: 14398

    OMIM: 606477

    KEGG: hsa:63826

    STRING: 9606.ENSP00000339435

    UniGene: Hs.461954



主站蜘蛛池模板： 日韩欧美中文字幕在线三区| 后入内射国产一区二区| 国产精品沙发午睡系列990531| 久久久亚洲精品无码| 国产偷久久久精品专区| 亚洲日韩欧美在线成人| 少妇性bbb搡bbb爽爽爽欧美| 国产青草视频在线观看| 国产亚洲精品久久久久久入口| 久久精品99久久香蕉国产| 澳门永久av免费网站| 无码精品人妻一区二区三区人妻斩 | 久精品视频在线观看免费| 丰满熟女人妻一区二区三| 热re99久久精品国产66热| av无码电影一区二区三区| 久久精品青青草原伊人| 国产成人精品999在线观看| 日韩丰满少妇无吗视频激情内射| 欧美高潮喷水大叫| av无码不卡一区二区三区| 人妻少妇中文字幕久久| 国产好爽…又高潮了毛片| 国产成人啪精品视频免费视频| 欧美日本日韩| 最新中文字幕av无码专区| 在线岛国片免费无码av| 亚洲综合欧美在线一区在线播放| 熟女人妻水多爽中文字幕| 亚洲人成影院在线无码按摩店| 伦理片无码电影在线看| 国产肉体xxxx裸体784大胆| 日韩精品无码一区二区三区| 日韩少妇白浆无码系列| 亚洲中文在线精品国产| 亚洲精品无码不卡在线播he| 国产蝌蚪视频一区二区三区| 18禁无遮挡无码国产免费网站| 人妻无码第一区二区三区| 男人女人午夜视频免费| 性色av一二三天美传媒|