在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Serine protease inhibitor Kazal-type 6 (SPINK6)

  • 中文名稱:
    Recombinant Human Serine protease inhibitor Kazal-type 6 (SPINK6)
  • 貨號:
    CSB-EP744263HU
  • 規格:
    ¥1536
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater?than?85%?as?determined?by?SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
    SPINK6
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    E.coli
  • 分子量:
    41.2 kDa
  • 表達區域:
    24-80aa
  • 氨基酸序列
    QGGQVDCGEFQDPKVYCTRESNPHCGSDGQTYGNKCAFCKAIVKSGGKISLKHPGKC
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-GST-tagged and C-terminal Myc-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8.
  • 基因功能參考文獻:
    1. Study showed that the expression of SPINK6 is specifically suppressed in liver tumor tissues. The suppression could be even detected in the early stage tumors. As SPINK6 is a secretory protein, the extracellular protein level may be decreased because of tumor development. These results support that SPINK6 is an important tumor suppressor in liver. PMID: 27999203
    2. our results identified a novel EGFR-activating mechanism in which SPINK6 has a critical role in promoting nasopharyngeal carcinoma metastasis PMID: 27671677
    3. a significant fraction of SPINK6-sensitive proteases in healthy saliva and confirmed the ability of gingipains to inactivate SPINK6 under ex vivo conditions PMID: 27354280
    4. KLKs. Thereby, beside the conserved binding mode, we identified an alternate binding mode which has so far not been observed for SPINK inhibitors. PMID: 26828269
    5. Our study indicates that Spink6 is a potent inhibitor of kallikrein related peptidases and involved in skin barrier function. PMID: 24352040
    6. Cross-linked SPINK6 might protect specific substrates such as fibronectin from kallikrein-related peptidases cleavage and contribute to the regulation of proteases in the epidermis. PMID: 23303447
    7. Serine protease of Kazal-type (SPINK6) expressed in normal human skin is a potent natural inhibitor of Kallikrein-related peptidases, KLK12 and KLK13. PMID: 21439340
    8. Data suggest that SPINK6 plays a role in modulating the activity of kallikreins in human skin. PMID: 20667819

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 數據庫鏈接:

    HGNC: 29486

    OMIM: 615868

    KEGG: hsa:404203

    STRING: 9606.ENSP00000324870

    UniGene: Hs.334274



主站蜘蛛池模板: 成人精品一区二区三区电影| 成人精品一区二区三区在线观看| 国产人妻人伦精品1国产盗摄| 午夜免费啪视频| 一本久久a久久精品综合| 9999国产精品欧美久久久久久| 亚洲精品无码鲁网中文电影| 性欧美vr高清极品| 无遮挡又爽又刺激的视频| 国产亚洲一卡2卡3卡4卡网站| 一边啪啪一边呻吟av夜夜嗨 | 欧洲美熟女乱又伦av影片| 野花在线无码视频在线播放| 亚洲性无码av在线dvd| 人妻 色综合网站| 男女免费观看做爰视频在线观看 | 久久欧美一区二区三区性生奴| 香蕉人妻av久久久久天天| 偷窥国产亚洲免费视频| 日韩人妻ol丝袜av一二区| 国产精品人妻一区二区三区四| 东京热人妻无码一区二区av| 久热这里在线精品| 欧美黑人又粗又大久久久| 97超级碰碰人妻中文字幕| 日韩卡1卡2 卡三卡免费| 亚洲中国精品精华液| 男女一边摸一边做爽爽| 在线中文字幕乱码英文字幕正常| 超caopor在线公开视频| 国产亚洲精品美女久久久| 免费视频欧美无人区码| 末发育女av片一区二区| 四虎成人精品永久在线视频| 少妇被粗大猛进进出出s小说 | 熟妇人妻久久中文字幕| 五月综合色婷婷在线观看| 亚洲精品亚洲人成在线下载| 欧美自拍嘿咻内射在线观看| 色综合 图片区 小说区| 日韩中文字幕在线专区|