在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SPINK6 Antibody

  • 中文名稱:
    SPINK6兔多克隆抗體
  • 貨號:
    CSB-PA579657
  • 規格:
    ¥2024
  • 圖片:
    • Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using SPINK6 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SPINK6 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SPINK6
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from internal of Human SPINK6.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:50-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8.
  • 基因功能參考文獻:
    1. Study showed that the expression of SPINK6 is specifically suppressed in liver tumor tissues. The suppression could be even detected in the early stage tumors. As SPINK6 is a secretory protein, the extracellular protein level may be decreased because of tumor development. These results support that SPINK6 is an important tumor suppressor in liver. PMID: 27999203
    2. our results identified a novel EGFR-activating mechanism in which SPINK6 has a critical role in promoting nasopharyngeal carcinoma metastasis PMID: 27671677
    3. a significant fraction of SPINK6-sensitive proteases in healthy saliva and confirmed the ability of gingipains to inactivate SPINK6 under ex vivo conditions PMID: 27354280
    4. KLKs. Thereby, beside the conserved binding mode, we identified an alternate binding mode which has so far not been observed for SPINK inhibitors. PMID: 26828269
    5. Our study indicates that Spink6 is a potent inhibitor of kallikrein related peptidases and involved in skin barrier function. PMID: 24352040
    6. Cross-linked SPINK6 might protect specific substrates such as fibronectin from kallikrein-related peptidases cleavage and contribute to the regulation of proteases in the epidermis. PMID: 23303447
    7. Serine protease of Kazal-type (SPINK6) expressed in normal human skin is a potent natural inhibitor of Kallikrein-related peptidases, KLK12 and KLK13. PMID: 21439340
    8. Data suggest that SPINK6 plays a role in modulating the activity of kallikreins in human skin. PMID: 20667819

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 數據庫鏈接:

    HGNC: 29486

    OMIM: 615868

    KEGG: hsa:404203

    STRING: 9606.ENSP00000324870

    UniGene: Hs.334274



主站蜘蛛池模板: 688欧美人禽杂交狂配| 琪琪女色窝窝777777| 中文乱码免费一区二区| 成 人 免 费 黄 色| 久久久精品94久久精品| 最近免费中文字幕mv在线视频3| 亚洲中文字幕无码一久久区| 日韩精品无码一区二区三区视频 | 亚洲老妈激情一区二区三区| 国产精品美女久久久免费| 国产精品色无码av在线观看| 少妇被又大又粗下爽a片| 日本熟妇中文字幕三级| 亚洲欧美丝袜精品久久| 国产一二三四区乱码免费| 一区二区三区国产精华液| а√在线中文网新版地址在线| 小嫩妇好紧好爽再快视频| 国产在线精品一区二区三区直播| 少妇精品揄拍高潮少妇| 亚洲成a∨人片在线观看不卡| 又黄又爽又色的视频| 国产精品嫩草影院免费观看| 中文字幕av一区| 性生交大全免费看| 伊人精品一本久久综合| 动漫精品视频一区二区三区| 国产免费艾彩sm调教视频| 特黄特级毛片免费视频| 国产亚洲精品国产福利你懂的| 国产香蕉97碰碰久久人人| 无码专区aaaaaa免费视频| 亚洲国产精品嫩草影院永久 | 四川少妇大战4黑人| 香蕉精品亚洲二区在线观看| 体内射精日本视频免费看| 国产精品久久久久久超碰| 国产精品igao视频网| 亚洲国产精品va在线观看麻豆| 久久久久99精品成人片试看| 国产 一二三四五六|