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  4. Recombinant Human Serine/arginine-rich splicing factor 6 (SRSF6)

Recombinant Human Serine/arginine-rich splicing factor 6 (SRSF6)

  • 中文名稱：
    人SRSF6重組蛋白
  • 貨號：
    CSB-YP623793HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SRSF6重組蛋白
  • 貨號：
    CSB-EP623793HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SRSF6重組蛋白
  • 貨號：
    CSB-EP623793HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SRSF6重組蛋白
  • 貨號：
    CSB-BP623793HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SRSF6重組蛋白
  • 貨號：
    CSB-MP623793HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SRSF6
  • Uniprot No.：
  • 別名：
    arginine/serine-rich 6; B52; Epididymis secretory protein Li 91; fc17h09; HEL S 91; MGC128807 ; MGC5045; Pre mRNA splicing factor SRP55; Pre-mRNA-splicing factor SRP55; Serine/arginine-rich splicing factor 6; SFRS6; Splicing factor; Splicing factor arginine/serine rich 55 kDa; Splicing factor arginine/serine rich 6; SR splicing factor 6; SRP55; SRSF6; SRSF6_HUMAN; wu:faa54g02; wu:fc17h09; zgc:103497
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-344
  • 氨基酸序列
    MPRVYIGRLS YNVREKDIQR FFSGYGRLLE VDLKNGYGFV EFEDSRDADD AVYELNGKEL CGERVIVEHA RGPRRDRDGY SYGSRSGGGG YSSRRTSGRD KYGPPVRTEY RLIVENLSSR CSWQDLKDFM RQAGEVTYAD AHKERTNEGV IEFRSYSDMK RALDKLDGTE INGRNIRLIE DKPRTSHRRS YSGSRSRSRS RRRSRSRSRR SSRSRSRSIS KSRSRSRSRS KGRSRSRSKG RKSRSKSKSK PKSDRGSHSH SRSRSKDEYE KSRSRSRSRS PKENGKGDIK SKSRSRSQSR SNSPLPVPPS KARSVSPPPK RATSRSRSRS RSKSRSRSRS SSRD
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing.
  • 基因功能參考文獻：
    1. Data suggest that regulation of pancreatic beta-cell function and survival/apoptosis involves alternative splicing modulated by key splicing regulator SRP55; SRP55-regulated alternative splicing includes modulation of function of pro-apoptotic proteins (BIM, BAX), JNK signaling, and endoplasmic reticulum stress. (BIM = BCL-2 interacting protein BIM; BAX = apoptosis regulator BAX) PMID: 29246973
    2. The recent studies suggest that correcting the SRSF6-driven missplicing and/or microtubule-associated imbalance might be of therapeutic value in Huntington's disease. PMID: 27529534
    3. LINC01133 inhibits epithelial mesenchymal transformation and metastasis in colorectal neoplasms by directly binding to SRSF6 as a target mimic. PMID: 27443606
    4. SRSF6 is a regulator of wound healing and tissue homeostasis in skin. PMID: 24440982
    5. Zinc inhibits the activity of SRSF6 and promotes elimination of exon 4, leading to preferential generation of BimS. PMID: 23648111
    6. The splicing factor SRSF6 is an oncoprotein that regulates the proliferation and survival of lung and colon cancer cells. PMID: 23132731
    7. Phosphorylation of SRp55 by Dyrk1A suppressed its ability to promote Tau exon 10 inclusion. PMID: 22767602
    8. Report upregulation of Bim and the splicing factor SRp55 in melanoma cells from patients treated with selective BRAF inhibitors. PMID: 22516966
    9. SRp55 aids in the generation of partially spliced and unspliced HIV-1 mRNAs. PMID: 21345357
    10. interacts with calcitonin/CGRP exon 4 exonic splice enhancer(ESE); binding of SRp55 to an ESE required for calcitonin mRNA splicing suggests that the different levels of SRp55 in different cell types may regulate calcitonin/CGRP alternative splicing PMID: 12531473
    11. SRp55 binding to a suboptimal RNA binding site in the calcitonin/CGRP pre-mRNA exonic splice enhancer, or increasing the amount of SRp55 in cells, is required for calcitonin mRNA production. PMID: 12549914
    12. Higher relative expression of SR55 protein in breast tumors was associated with altered pattern of CD44 variants incorporating exon v7 PMID: 12779084
    13. These findings show that modulation of splicing activity in p53-deficient cells during the early response to sub-lethal DNA damage results in a change in the splicing of target genes, thus modifying the cellular response to genotoxic agents. PMID: 18571879

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  • 亞細胞定位：
    Nucleus. Nucleus speckle.
  • 蛋白家族：
    Splicing factor SR family
  • 數據庫鏈接：

    HGNC: 10788

    OMIM: 601944

    KEGG: hsa:6431

    STRING: 9606.ENSP00000244020

    UniGene: Hs.684950



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