在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Secretogranin-1 (CHGB)

Recombinant Human Secretogranin-1 (CHGB)

  • 中文名稱：
    Recombinant Human Secretogranin-1(CHGB)
  • 貨號：
    CSB-YP005345HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Secretogranin-1(CHGB)
  • 貨號：
    CSB-EP005345HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Secretogranin-1(CHGB)
  • 貨號：
    CSB-EP005345HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Secretogranin-1(CHGB)
  • 貨號：
    CSB-BP005345HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Secretogranin-1(CHGB)
  • 貨號：
    CSB-MP005345HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CHGB
  • Uniprot No.：
  • 別名：
    CCB peptide; Cg B; CgB; Chgb; Chromogranin-B; ChromograninB; SCG1; SCG1_HUMAN; Secretogranin 1; Secretogranin B; Secretogranin I; SgI
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    21-677
  • 氨基酸序列
    MPVDNRNHNE GMVTRCIIEV LSNALSKSSA PPITPECRQV LKTSRKDVKD KETTENENTK FEVRLLRDPA DASEAHESSS RGEAGAPGEE DIQGPTKADT EKWAEGGGHS RERADEPQWS LYPSDSQVSE EVKTRHSEKS QREDEEEEEG ENYQKGERGE DSSEEKHLEE PGETQNAFLN ERKQASAIKK EELVARSETH AAGHSQEKTH SREKSSQESG EETGSQENHP QESKGQPRSQ EESEEGEEDA TSEVDKRRTR PRHHHGRSRP DRSSQGGSLP SEEKGHPQEE SEESNVSMAS LGEKRDHHST HYRASEEEPE YGEEIKGYPG VQAPEDLEWE RYRGRGSEEY RAPRPQSEES WDEEDKRNYP SLELDKMAHG YGEESEEERG LEPGKGRHHR GRGGEPRAYF MSDTREEKRF LGEGHHRVQE NQMDKARRHP QGAWKELDRN YLNYGEEGAP GKWQQQGDLQ DTKENREEAR FQDKQYSSHH TAEKRKRLGE LFNPYYDPLQ WKSSHFERRD NMNDNFLEGE EENELTLNEK NFFPEYNYDW WEKKPFSEDV NWGYEKRNLA RVPKLDLKRQ YDRVAQLDQL LHYRKKSAEF PDFYDSEEPV STHQEAENEK DRADQTVLTE DEKKELENLA AMDLELQKIA EKFSQRG
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.
  • 基因功能參考文獻：
    1. evidence suggests that the P413L variant of chromogranin B is not associated with amyotrophic lateral sclerosis (ALS) risk or age at ALS onset (meta-analysis). PMID: 28795874
    2. Data suggest that chromogranin B (CGB) is a promising emerging biomarker in heart failure (HF) patients with unique potential to integrate information from myocardial stress and neuro-endocrine activation. PMID: 29098879
    3. Circulating chromogranin B (CgB) levels measured on Intensive Care Unit (ICU) admission provided additional prognostic information to established risk indices in acute respiratory failure (ARF) patients. PMID: 28049363
    4. results presented here suggest that CHGB variant alleles, the rare CHGB-L413 and common CHGB-P413, may act as modifiers of ALS disease dependent on their expression levels which is higher in females because of a sex-determining region Y element in the CHGB gene promoter. PMID: 28175304
    5. our results suggest that genetic variants of CHGB may have sex-specific effects on the risk of schizophrenia and provide useful preliminary information for further study. PMID: 28332369
    6. intracellular calcium binding protein Sg1 is increased in early multiple sclerosis (MS) patients compared to relapsing-remitting MS and neurological controls. PMID: 26152395
    7. The polymorphism P413L in the CHGB gene was not associated with sporadic amyotrophic lateral sclerosis in a group of Italian patients. PMID: 26003296
    8. A heterogeneous response to short- and long-term physical activities among circulating granin proteins, particularly chromogranin B. PMID: 23816467
    9. Results do not support the 413L variant of chromogranin B as a risk factor for sporadic amyotrophic lateral sclerosis in the French population. PMID: 20932227
    10. common polymorphism in the 3'-UTR (C+84A) of CHGB, which disrupts an A/U-rich messenger ribonucleic acid stability element, associates with not only CHGB secretion but also excretion of isoprostane PMID: 20888525
    11. The common CHGB promoter variants A-296C and A-261T, and their consequent haplotypes, alter binding of specific transcription factors to influence gene expression in cella as well as BP in vivo PMID: 20359597
    12. Genetic variation at the CHGB locus, in the proximal promoter, influences CHGB expression as well as catecholamine secretion and later the early heritable responses to environmental stress, and resting/basal Blood Pressure in the population. PMID: 20011129
    13. finding that CHGB may act as a susceptibility gene and modifier of onset in ALS is consistent with the emerging view that dysfunction of the secretory pathway may contribute to increased vulnerability of motor neurons PMID: 20007371
    14. Chromogranin B was selected as a candidate gene for schizophrenia. We systematically screened all the promoter and exon regions of the gene and detected 15 single nucleotide polymorphisms in a Chinese population. PMID: 11959426
    15. CgB may play some role in the early phase of neoplastic progression PMID: 12165659
    16. there are four different types of chromogranin B in pancreatic islets as demonstrated by region-specific antibodies PMID: 12438147
    17. 5 CgB fragments were measured in plasma: CgB1-16, CgB312-331, CgB439-451, CgB568-577, & CgB647-657. Substantial heritability, as measured by h2r, was observed for 3 of the fragment concentrations, CgB312-331, CgB439-451, and CgB568-577. PMID: 15138309
    18. 10 microsatellite markers were analyzed, and an association of schizophrenia was found with D20S882 and D20S905 that flank D20S95. The chromogranin B gene is 30 kb from D20S905. PMID: 15219467
    19. Overall, our results suggest that at least one locus in or close to the CHGB gene confers risk of the disorder and strengthen the evidence that CHGB is a promising susceptibility gene for schizophrenia in Chinese population. PMID: 17143778
    20. Locally infused tyramine produced dose-dependent pressor responses, predicted by family history of hypertension, sex, and genetic variants at loci, particularly CHGB, that encode the biosynthesis, storage, and metabolism of catecholamines. PMID: 18180394
    21. semiquantitative immunocytochemistry for chromogranin B in amyotrophic lateral sclerosis PMID: 18721831

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted. Note=Neuroendocrine and endocrine secretory granules.
  • 蛋白家族：
    Chromogranin/secretogranin protein family
  • 組織特異性：
    Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver.
  • 數據庫鏈接：

    HGNC: 1930

    OMIM: 118920

    KEGG: hsa:1114

    STRING: 9606.ENSP00000368244

    UniGene: Hs.516874



主站蜘蛛池模板： 96亚洲精华国产精华精华液| 丰满少妇高潮惨叫久久久一| 精品毛片乱码1区2区3区 | 欧美大屁股熟妇bbbbbb| av色综合久久天堂av色综合在| 欧美精品亚洲精品日韩专区va| 少妇被粗大的猛进出69影院| 国产手机在线无码播放视频| 久久这里只有精品首页| 亚洲精品熟女国产| 亚洲男人片片在线观看| 天天做日日做天天添天天欢公交车 | 亚洲一区二区三区四区五区六区| 狠狠色噜噜狠狠狠狠av| 久久人人97超碰国产亚洲人| 99精品国产福利一区二区| 精品国产av一区二区三区| 中文字幕日本人妻久久久免费| 久久久橹橹橹久久久久高清| 日韩午夜理论片 中文字幕| 免费无码一区二区三区a片百度| 各处沟厕大尺度偷拍女厕嘘嘘| 亚洲一区波多野结衣在线| 性亚洲videofree高清| 亚洲精品乱码久久久久久金桔影视| 男人女人午夜视频免费| 伊人久久大香线蕉综合bd高清| 久久av无码精品人妻系列试探| 婷婷五月综合色视频| 女人被狂c到高潮视频网站| 2022一本久道久久综合狂躁| 国产超碰人人做人人爱ⅴa| 亚洲动漫精品无码av天堂| 精品人妻系列无码专区| 四虎影视在线影院在线观看免费视频 | 亚洲日韩v无码中文字幕| 又粗又紧又湿又爽的视频| 国产精品系列无码专区| 一本之道高清无码视频| 精品无码欧美黑人又粗又| 成码无人av片在线电影网站|