在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Secretogranin-1 (CHGB)

Recombinant Human Secretogranin-1 (CHGB)

  • 中文名稱：
    Recombinant Human Secretogranin-1(CHGB)
  • 貨號：
    CSB-YP005345HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Secretogranin-1(CHGB)
  • 貨號：
    CSB-EP005345HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Secretogranin-1(CHGB)
  • 貨號：
    CSB-EP005345HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Secretogranin-1(CHGB)
  • 貨號：
    CSB-BP005345HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Secretogranin-1(CHGB)
  • 貨號：
    CSB-MP005345HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    CHGB
  • Uniprot No.：
  • 別名：
    CCB peptide; Cg B; CgB; Chgb; Chromogranin-B; ChromograninB; SCG1; SCG1_HUMAN; Secretogranin 1; Secretogranin B; Secretogranin I; SgI
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    21-677
  • 氨基酸序列
    MPVDNRNHNE GMVTRCIIEV LSNALSKSSA PPITPECRQV LKTSRKDVKD KETTENENTK FEVRLLRDPA DASEAHESSS RGEAGAPGEE DIQGPTKADT EKWAEGGGHS RERADEPQWS LYPSDSQVSE EVKTRHSEKS QREDEEEEEG ENYQKGERGE DSSEEKHLEE PGETQNAFLN ERKQASAIKK EELVARSETH AAGHSQEKTH SREKSSQESG EETGSQENHP QESKGQPRSQ EESEEGEEDA TSEVDKRRTR PRHHHGRSRP DRSSQGGSLP SEEKGHPQEE SEESNVSMAS LGEKRDHHST HYRASEEEPE YGEEIKGYPG VQAPEDLEWE RYRGRGSEEY RAPRPQSEES WDEEDKRNYP SLELDKMAHG YGEESEEERG LEPGKGRHHR GRGGEPRAYF MSDTREEKRF LGEGHHRVQE NQMDKARRHP QGAWKELDRN YLNYGEEGAP GKWQQQGDLQ DTKENREEAR FQDKQYSSHH TAEKRKRLGE LFNPYYDPLQ WKSSHFERRD NMNDNFLEGE EENELTLNEK NFFPEYNYDW WEKKPFSEDV NWGYEKRNLA RVPKLDLKRQ YDRVAQLDQL LHYRKKSAEF PDFYDSEEPV STHQEAENEK DRADQTVLTE DEKKELENLA AMDLELQKIA EKFSQRG
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.
  • 基因功能參考文獻：
    1. evidence suggests that the P413L variant of chromogranin B is not associated with amyotrophic lateral sclerosis (ALS) risk or age at ALS onset (meta-analysis). PMID: 28795874
    2. Data suggest that chromogranin B (CGB) is a promising emerging biomarker in heart failure (HF) patients with unique potential to integrate information from myocardial stress and neuro-endocrine activation. PMID: 29098879
    3. Circulating chromogranin B (CgB) levels measured on Intensive Care Unit (ICU) admission provided additional prognostic information to established risk indices in acute respiratory failure (ARF) patients. PMID: 28049363
    4. results presented here suggest that CHGB variant alleles, the rare CHGB-L413 and common CHGB-P413, may act as modifiers of ALS disease dependent on their expression levels which is higher in females because of a sex-determining region Y element in the CHGB gene promoter. PMID: 28175304
    5. our results suggest that genetic variants of CHGB may have sex-specific effects on the risk of schizophrenia and provide useful preliminary information for further study. PMID: 28332369
    6. intracellular calcium binding protein Sg1 is increased in early multiple sclerosis (MS) patients compared to relapsing-remitting MS and neurological controls. PMID: 26152395
    7. The polymorphism P413L in the CHGB gene was not associated with sporadic amyotrophic lateral sclerosis in a group of Italian patients. PMID: 26003296
    8. A heterogeneous response to short- and long-term physical activities among circulating granin proteins, particularly chromogranin B. PMID: 23816467
    9. Results do not support the 413L variant of chromogranin B as a risk factor for sporadic amyotrophic lateral sclerosis in the French population. PMID: 20932227
    10. common polymorphism in the 3'-UTR (C+84A) of CHGB, which disrupts an A/U-rich messenger ribonucleic acid stability element, associates with not only CHGB secretion but also excretion of isoprostane PMID: 20888525
    11. The common CHGB promoter variants A-296C and A-261T, and their consequent haplotypes, alter binding of specific transcription factors to influence gene expression in cella as well as BP in vivo PMID: 20359597
    12. Genetic variation at the CHGB locus, in the proximal promoter, influences CHGB expression as well as catecholamine secretion and later the early heritable responses to environmental stress, and resting/basal Blood Pressure in the population. PMID: 20011129
    13. finding that CHGB may act as a susceptibility gene and modifier of onset in ALS is consistent with the emerging view that dysfunction of the secretory pathway may contribute to increased vulnerability of motor neurons PMID: 20007371
    14. Chromogranin B was selected as a candidate gene for schizophrenia. We systematically screened all the promoter and exon regions of the gene and detected 15 single nucleotide polymorphisms in a Chinese population. PMID: 11959426
    15. CgB may play some role in the early phase of neoplastic progression PMID: 12165659
    16. there are four different types of chromogranin B in pancreatic islets as demonstrated by region-specific antibodies PMID: 12438147
    17. 5 CgB fragments were measured in plasma: CgB1-16, CgB312-331, CgB439-451, CgB568-577, & CgB647-657. Substantial heritability, as measured by h2r, was observed for 3 of the fragment concentrations, CgB312-331, CgB439-451, and CgB568-577. PMID: 15138309
    18. 10 microsatellite markers were analyzed, and an association of schizophrenia was found with D20S882 and D20S905 that flank D20S95. The chromogranin B gene is 30 kb from D20S905. PMID: 15219467
    19. Overall, our results suggest that at least one locus in or close to the CHGB gene confers risk of the disorder and strengthen the evidence that CHGB is a promising susceptibility gene for schizophrenia in Chinese population. PMID: 17143778
    20. Locally infused tyramine produced dose-dependent pressor responses, predicted by family history of hypertension, sex, and genetic variants at loci, particularly CHGB, that encode the biosynthesis, storage, and metabolism of catecholamines. PMID: 18180394
    21. semiquantitative immunocytochemistry for chromogranin B in amyotrophic lateral sclerosis PMID: 18721831

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted. Note=Neuroendocrine and endocrine secretory granules.
  • 蛋白家族：
    Chromogranin/secretogranin protein family
  • 組織特異性：
    Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver.
  • 數據庫鏈接：

    HGNC: 1930

    OMIM: 118920

    KEGG: hsa:1114

    STRING: 9606.ENSP00000368244

    UniGene: Hs.516874



主站蜘蛛池模板： 性一交一乱一伦一| 欧美性猛交xxxx乱大交| 色哟哟精品视频在线观看| 欧美牲交a欧美牲交aⅴ免费真| 欧美老人巨大xxxx做受视频 | 亚洲成a人片在线观看天堂| 蜜臀avwww国产天堂| 亚洲成av人片不卡无码| 色婷婷综合久久久久中文字幕 | 新区乱码无人区二精东| 亚洲一区在线日韩在线尤物| 国产精品久久久久久不卡盗摄| 在线 | 一区二区三区四区| 香蕉久久久久久av成人| 77777五月色婷婷丁香视频| 国产成人精品a∨一区二区| 国产成人无码av一区二区| 苍井空张开腿实干12次| 国产-第1页-浮力影院| 亚洲国产成人精品无码区在线秒播| 宅男午夜成年影视在线观看| 男女做爰无遮挡性视频| 艳妇荡女欲乱双飞两中年熟妇 | 亚洲娇小与黑人巨大交| 无码中文字幕日韩专区视频| 国产二级一片内射视频播放| 国产精品乱子伦xxxx裸| 人妻无码av中文系列久| 亚洲人成网线在线播放va蜜芽| 丰满岳跪趴高撅肥臀尤物在线观看| 久久香综合精品久久伊人| 亚洲国产成人久久精品99| 日本va在线视频播放| 欧美性生 活18~19| 人妻人人澡人人添人人爽人人玩| 国产在线观看免费人成视频| 久久不见久久见免费影院www| 国产成人精品a视频一区| 国产成人a区在线观看| 99久热国产精品视频尤物| 性开放的女人aaa片|