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Human secretogranin-1 (chromogranin-B)(CHGB/SCG1)ELISA kit

  • 中文名稱:
    人分泌粒蛋白1(嗜鉻粒蛋白B)(CHGB/SCG1)酶聯免疫試劑盒
  • 貨號:
    CSB-E17547h
  • 規格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產品詳情

  • 產品描述:
    人分泌粒蛋白1(嗜鉻粒蛋白B)(CHGB/SCG1)酶聯免疫試劑盒(CSB-E17547h)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿.樣本中的CHGB含量。試劑盒檢測范圍為1.56 ng/ml- 100 ng/ml,靈敏度為0.39 ng/ml。該產品可為神經內分泌系統功能研究、疾病模型構建、藥物作用機制探索等科研場景提供數據支持,例如評估實驗條件下CHGB的分泌動態或病理組織中蛋白表達差異本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    CCB peptide ELISA Kit; Cg B ELISA Kit; CgB ELISA Kit; Chgb ELISA Kit; Chromogranin-B ELISA Kit; ChromograninB ELISA Kit; SCG1 ELISA Kit; SCG1_HUMAN ELISA Kit; Secretogranin 1 ELISA Kit; Secretogranin B ELISA Kit; Secretogranin I ELISA Kit; SgI ELISA Kit
  • 縮寫:
    CHGB
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 樣本類型:
    serum, plasma, tissue homogenates
  • 檢測范圍:
    1.56 ng/ml-100 ng/ml
  • 靈敏度:
    0.39 ng/ml
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Neuroscience
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 精密度:

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

  • 線性度:

    To assess the linearity of the assay, samples were spiked with high concentrations of human CHGB/SCG1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

     

    Sample

    Serum(n=4)

    1:1

    Average %

    91

    Range %

    85-97

    1:2

    Average %

    96

    Range %

    92-102

    1:4

    Average %

    102

    Range %

    95-109

    1:8

    Average %

    88

    Range %

    86-90

  • 回收率:

    The recovery of human CHGB/SCG1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

    Sample Type

    Average % Recovery

    Range

    Serum (n=5)

    91

    86-96

    EDTA plasma (n=4)

    98

    94-102

  • 標準曲線:

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

    ng/ml

    OD1

    OD2

    Average

    Corrected

    100

    2.364

    2.560

    2.462

    2.317

    50

    1.901

    1.986

    1.944

    1.799

    25

    1.413

    1.522

    1.468

    1.323

    12.5

    0.972

    1.052

    1.012

    0.867

    6.25

    0.625

    0.624

    0.625

    0.480

    3.125

    0.379

    0.359

    0.369

    0.224

    1.56

    0.264

    0.267

    0.266

    0.121

    0

    0.142

    0.147

    0.145

     

  • 數據處理:
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 功能:
    Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.
  • 基因功能參考文獻:
    1. evidence suggests that the P413L variant of chromogranin B is not associated with amyotrophic lateral sclerosis (ALS) risk or age at ALS onset (meta-analysis). PMID: 28795874
    2. Data suggest that chromogranin B (CGB) is a promising emerging biomarker in heart failure (HF) patients with unique potential to integrate information from myocardial stress and neuro-endocrine activation. PMID: 29098879
    3. Circulating chromogranin B (CgB) levels measured on Intensive Care Unit (ICU) admission provided additional prognostic information to established risk indices in acute respiratory failure (ARF) patients. PMID: 28049363
    4. results presented here suggest that CHGB variant alleles, the rare CHGB-L413 and common CHGB-P413, may act as modifiers of ALS disease dependent on their expression levels which is higher in females because of a sex-determining region Y element in the CHGB gene promoter. PMID: 28175304
    5. our results suggest that genetic variants of CHGB may have sex-specific effects on the risk of schizophrenia and provide useful preliminary information for further study. PMID: 28332369
    6. intracellular calcium binding protein Sg1 is increased in early multiple sclerosis (MS) patients compared to relapsing-remitting MS and neurological controls. PMID: 26152395
    7. The polymorphism P413L in the CHGB gene was not associated with sporadic amyotrophic lateral sclerosis in a group of Italian patients. PMID: 26003296
    8. A heterogeneous response to short- and long-term physical activities among circulating granin proteins, particularly chromogranin B. PMID: 23816467
    9. Results do not support the 413L variant of chromogranin B as a risk factor for sporadic amyotrophic lateral sclerosis in the French population. PMID: 20932227
    10. common polymorphism in the 3'-UTR (C+84A) of CHGB, which disrupts an A/U-rich messenger ribonucleic acid stability element, associates with not only CHGB secretion but also excretion of isoprostane PMID: 20888525
    11. The common CHGB promoter variants A-296C and A-261T, and their consequent haplotypes, alter binding of specific transcription factors to influence gene expression in cella as well as BP in vivo PMID: 20359597
    12. Genetic variation at the CHGB locus, in the proximal promoter, influences CHGB expression as well as catecholamine secretion and later the early heritable responses to environmental stress, and resting/basal Blood Pressure in the population. PMID: 20011129
    13. finding that CHGB may act as a susceptibility gene and modifier of onset in ALS is consistent with the emerging view that dysfunction of the secretory pathway may contribute to increased vulnerability of motor neurons PMID: 20007371
    14. Chromogranin B was selected as a candidate gene for schizophrenia. We systematically screened all the promoter and exon regions of the gene and detected 15 single nucleotide polymorphisms in a Chinese population. PMID: 11959426
    15. CgB may play some role in the early phase of neoplastic progression PMID: 12165659
    16. there are four different types of chromogranin B in pancreatic islets as demonstrated by region-specific antibodies PMID: 12438147
    17. 5 CgB fragments were measured in plasma: CgB1-16, CgB312-331, CgB439-451, CgB568-577, & CgB647-657. Substantial heritability, as measured by h2r, was observed for 3 of the fragment concentrations, CgB312-331, CgB439-451, and CgB568-577. PMID: 15138309
    18. 10 microsatellite markers were analyzed, and an association of schizophrenia was found with D20S882 and D20S905 that flank D20S95. The chromogranin B gene is 30 kb from D20S905. PMID: 15219467
    19. Overall, our results suggest that at least one locus in or close to the CHGB gene confers risk of the disorder and strengthen the evidence that CHGB is a promising susceptibility gene for schizophrenia in Chinese population. PMID: 17143778
    20. Locally infused tyramine produced dose-dependent pressor responses, predicted by family history of hypertension, sex, and genetic variants at loci, particularly CHGB, that encode the biosynthesis, storage, and metabolism of catecholamines. PMID: 18180394
    21. semiquantitative immunocytochemistry for chromogranin B in amyotrophic lateral sclerosis PMID: 18721831

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  • 亞細胞定位:
    Secreted. Note=Neuroendocrine and endocrine secretory granules.
  • 蛋白家族:
    Chromogranin/secretogranin protein family
  • 組織特異性:
    Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver.
  • 數據庫鏈接:

    HGNC: 1930

    OMIM: 118920

    KEGG: hsa:1114

    STRING: 9606.ENSP00000368244

    UniGene: Hs.516874



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