在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Sclerostin domain-containing protein 1 (SOSTDC1)

  • 中文名稱:
    人SOSTDC1重組蛋白
  • 貨號(hào):
    CSB-MP022416HU
  • 規(guī)格:
    ¥2376
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
  • Uniprot No.:
  • 別名:
    Ectodermal BMP inhibitor ;EctodinUterine sensitization-associated gene 1 protein ;USAG-1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度:
    Full Length of Mature Protein
  • 來(lái)源:
    Mammalian cell
  • 分子量:
    49.7 kDa
  • 表達(dá)區(qū)域:
    24-206aa
  • 氨基酸序列
    FKNDATEILYSHVVKPVPAHPSSNSTLNQARNGGRHFSNTGLDRNTRVQVGCRELRSTKYISDGQCTSISPLKELVCAGECLPLPVLPNWIGGGYGTKYWSRRSSQEWRCVNDKTRTQRIQLQCQDGSTRTYKITVVTACKCKRYTRQHNESSHNFESMSPAKPVQHHRERKRASKSSKHSMS
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    C-terminal hFc1-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling. Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner.
  • 基因功能參考文獻(xiàn):
    1. findings provide insight into the role of SOSTDC1 as a novel functional tumor suppressor in follicular thyroid cancer through modulating the activities of PI3K/Akt and MAPK/Erk signaling pathways. PMID: 28551845
    2. Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2. PMID: 26378658
    3. Results conclude that the transcriptional repressor E4BP4 plays a role in repressing epigenetically regulated SOSTDC1 expression in breast cancer cells, which can be reverted by E4BP4 silencing. PMID: 25338303
    4. Epigenetic silencing of SOSTDC1 through methylation is increased in prostate cancer and is associated with accelerated disease progression in patients with prostate cancer PMID: 25858146
    5. Unliganded VDR upregulates the expression of hairless, the gene product of which acts as a downstream comodulator to feedback-repress DKKL1 and SOSTDC1. PMID: 24190897
    6. DNA methylation is involved in the down-regulation of SOSTDC1 expression in gastric cancer. PMID: 23830730
    7. SOSTDC1 is expressed in normal breast tissue and this expression is reduced in breast cancer. PMID: 21113658
    8. Results indicate for the first time that the genetic polymorphisms in SOSTDC1 have an effect on attainment and maintenance of peak bone mass in Chinese women. PMID: 21221677
    9. genetic aberrations near SOSTDC1 are not uncommon in renal cancer, and occur in adult as well as pediatric renal tumors. PMID: 21080955
    10. Data suggest that ectodin is a novel bone morphogenetic protein (BMP) inhibitor which integrates BMP signaling with the SHH and FGF signal pathways PMID: 14623234
    11. USAG1 is expressed in the kidney and functions as a bone morphogenetic protein antagonist. PMID: 15020244
    12. This screen identified a bone morphogenetic protein (BMP) antagonist, SOSTDC1 (sclerostin domain-containing-1) as down-regulated in kidney tumors. PMID: 18032587
    13. Loss of SOSTDC1 gene is associated with Wilms tumor. PMID: 19760604

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Secreted.
  • 蛋白家族:
    Sclerostin family
  • 組織特異性:
    Highly expressed in kidney and weakly in lung.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 21748

    OMIM: 609675

    KEGG: hsa:25928

    STRING: 9606.ENSP00000304930

    UniGene: Hs.648106



主站蜘蛛池模板: 久久综合色一综合色88| 色欲色香天天天综合网www | 夜夜爱夜鲁夜鲁很鲁| 亚洲精品一区二区三区四区乱码| 国产另类ts人妖一区二区| 国产精品自在线拍国产| 97久久婷婷五月综合色d啪蜜芽| 亚洲日本乱码在线观看| 国产在线拍揄自揄拍无码视频| 国自产偷精品不卡在线| 亚洲精品动漫免费二区| 狠狠做深爱婷婷丁香综合| 伊人久久大香线蕉精品| 国产成人精品av| 免费看少妇作爱视频| 国产手机在线国内精品| 亚洲国产成av人天堂无码| 国产亚洲精品a片久久久| 一本大道无码人妻精品专区| 免费观看全黄做爰的视频| 人妻少妇乱子伦精品| 欧美丰满老熟妇乱叫| 大陆国语对白国产av片| 香蕉久久久久久av成人| 玖玖玖国产精品视频| 无码视频免费一区二区三区| 久久无码人妻一区二区三区午夜 | 亚洲色欲www综合网| 国产高清视频在线观看97| 欧美三级午夜理伦三级| 午夜片无码区私人影院| 51妺嘿嘿午夜福利| 国产成人亚洲日韩欧美| 少妇被多人c夜夜爽爽| 亚洲五月综合缴情在线| 国产区精品系列在线观看| 亚洲国产精品成人影片久久| 午夜免费男女aaaa片| 无码国产精品一区二区免费虚拟vr| 女人被狂c到高潮视频网站| 在线看片国产日韩欧美亚洲|