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  4. Recombinant Human Schlafen family member 14 (SLFN14), partial

Recombinant Human Schlafen family member 14 (SLFN14), partial

  • 中文名稱：
    人SLFN14重組蛋白
  • 貨號(hào)：
    CSB-YP021764HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SLFN14重組蛋白
  • 貨號(hào)：
    CSB-EP021764HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SLFN14重組蛋白
  • 貨號(hào)：
    CSB-EP021764HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SLFN14重組蛋白
  • 貨號(hào)：
    CSB-BP021764HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SLFN14重組蛋白
  • 貨號(hào)：
    CSB-MP021764HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SLFN14
  • Uniprot No.：
  • 別名：
    Schlafen family member 14; SLFN14; SLN14_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Shows no ribosome-associated and endoribonuclease activities.; Displays polysome-associated endoribonuclease activity towards mRNAs and rRNAs. May play a role in RNA surveillance pathways by recognizing stalled ribosomes and triggering endonucleolytic cleavage of aberrant mRNAs. Cleaves different types of rRNAs and mRNAs in a magnesium- and manganese-dependent and ATP-independent manner. Involved in correct maturation of megakaryocytes and especially important for proplatelet extension.
  • 基因功能參考文獻(xiàn)：
    1. SLFN14 colocalizes with ribosomes and causes the endoribonucleolytic degradation of rRNA in cells. PMID: 29678925
    2. these data suggest that SLFN14 is a novel antiviral factor for both DNA and RNA viruses PMID: 28734654
    3. In a family with three affected individuals we found the c.667C>T variant in SLFN14 predicted to result in the p.Arg223Trp substitution within the ATPase- AAA-4 domain of SLFN14. The variant segregated with macrothrombocytopenia within the pedigree. PMID: 26769223
    4. These results identify SLFN14 mutations as cause for an inherited thrombocytopenia with excessive bleeding, outlining a fundamental role for SLFN14 in platelet formation and function. PMID: 26280575
  • 相關(guān)疾病：
    Bleeding disorder, platelet-type 20 (BDPLT20)
  • 亞細(xì)胞定位：
    [Protein SLFN14]: Nucleus.
  • 蛋白家族：
    Schlafen family
  • 組織特異性：
    Expressed in megakaryocytes and platelets (at protein level). Weakly expressed in melanocytes and malignant melanoma cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 32689

    OMIM: 614958

    KEGG: hsa:342618

    UniGene: Hs.591193



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