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  4. Recombinant Human Scavenger receptor class A member 3 (SCARA3), partial

Recombinant Human Scavenger receptor class A member 3 (SCARA3), partial

  • 中文名稱：
    人SCARA3重組蛋白
  • 貨號：
    CSB-YP721489HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SCARA3重組蛋白
  • 貨號：
    CSB-EP721489HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SCARA3重組蛋白
  • 貨號：
    CSB-EP721489HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SCARA3重組蛋白
  • 貨號：
    CSB-BP721489HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SCARA3重組蛋白
  • 貨號：
    CSB-MP721489HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SCARA3
  • Uniprot No.：
  • 別名：
    APC7; Cellular stress response; Cellular stress response gene protein; CSR; CSR1; Macrophage scavenger receptor-like 1; MSLR1; MSRL1; SCAR3_HUMAN; SCARA3; Scavenger receptor class A member 3
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation.
  • 基因功能參考文獻：
    1. CSR1 is SUMOylated at K582 and rapid ubiquitinated and degradated in prostate cancer cells. PMID: 29705808
    2. demonstrated that CSR1 inhibited hepatocellular carcinoma cell proliferation, migration and invasion through inactivation of hematopoietic PBX interacting protein (HPIP) and its downstream PI3K/AKT signaling pathway. PMID: 28975986
    3. Suppression of CSR1 expression is a novel mechanism critical for the oncogenic activity of miR-650. PMID: 25956032
    4. Findings regarding the interaction of NADPH-P450 reductase (NPR) with cellular stress response (CSR) indicated function of NPR in hypoxic response. PMID: 24491563
    5. Data indicate that the clinical samples showed an inverse correlation between SCARA3 gene expression, myeloma progression, and favorable clinical prognosis. PMID: 23537707
    6. The binding of CSR1 with XIAP enhanced caspase-9 and caspase-3 protease activities. PMID: 22683311
    7. The consistently high SCARA3 levels in both primary carcinomas and metastatic cells in effusions, and its up-regulation along disease progression from diagnosis to recurrence, suggest a role in ovarian cancer biology. PMID: 21855113
    8. Results demonstrate the involvement of SCARA3 and SCARA5 in the uptake of PF14-oligonucleotide nanocomplexes. PMID: 22138034
    9. Down-regulation of CSR1 protein expression by promoter methylation is associated with tumor growth and metastasis of prostate cancer PMID: 16436673
    10. CSR1 appears to induce cell death through a novel mechanism by hijacking a critical RNA processing enzyme CPSF3. PMID: 18806823

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  • 亞細胞定位：
    Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Note=Endoplasmic reticulum and/or Golgi.
  • 組織特異性：
    Expressed ubiquitously.
  • 數據庫鏈接：

    HGNC: 19000

    OMIM: 602728

    KEGG: hsa:51435

    STRING: 9606.ENSP00000301904

    UniGene: Hs.128856



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