在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁(yè)
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human SRA stem-loop-interacting RNA-binding protein, mitochondrial (SLIRP), partial

Recombinant Human SRA stem-loop-interacting RNA-binding protein, mitochondrial (SLIRP), partial

  • 中文名稱：
    人SLIRP重組蛋白
  • 貨號(hào)：
    CSB-YP867111HU
  • 說(shuō)明書：
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    人SLIRP重組蛋白
  • 貨號(hào)：
    CSB-EP867111HU
  • 說(shuō)明書：
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    人SLIRP重組蛋白
  • 貨號(hào)：
    CSB-EP867111HU-B
  • 說(shuō)明書：
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SLIRP重組蛋白
  • 貨號(hào)：
    CSB-BP867111HU
  • 說(shuō)明書：
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SLIRP重組蛋白
  • 貨號(hào)：
    CSB-MP867111HU
  • 說(shuō)明書：
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SLIRP
  • Uniprot No.：
  • 別名：
    SLIRP; C14orf156; DC23; DC50; PD04872; SRA stem-loop-interacting RNA-binding protein; mitochondrial
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Partial
  • 表達(dá)區(qū)域：
    -
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation.
  • 基因功能參考文獻(xiàn)：
    1. Study demonstrated that the LRPPRC-SLIRP complex is a global RNA chaperone that stabilizes RNA structures to expose the required sites for translation, stabilization, and polyadenylation. PMID: 29146908
    2. assessed, by using CRISPR-Cas9-introduced affinity tag and ChIP-Seq analysis, the genome-wide occupancy of SLIRP, and showed that the protein binds preferentially to G-rich DNA sequences that can fold into G4 structures PMID: 28859475
    3. LRPPRC displays a broad and strong RNA binding capacity in vitro in contrast to SLIRP that associates only weakly with RNA. PMID: 27353330
    4. Although SLIRP is not involved in mediating bcl-2 ability to protect from apoptosis and oxidative damage, bcl-2 binds and stabilizes SLIRP protein and regulates mitochondrial mRNA levels. The BH4 domain of bcl-2 has a role in maintaining this binding. PMID: 26866271
    5. The LRPPRC/SLIRP complex suppressed 3' exonucleolytic mRNA degradation mediated by PNPase and SUV3. PMID: 22661577
    6. LRPPRC exists in a high-molecular-weight complex, and it coimmunoprecipitates with SLIRP, a stem-loop RNA-binding protein. PMID: 20200222
    7. Our data demonstrate that SLIRP modulates NR transactivation, suggest it may regulate mitochondrial function, and provide mechanistic insight into interactions between SRA, SLIRP, SRC-1, and NCoR. PMID: 16762838
    8. SLIRP plays an essential role in maintaining mitochondrial-localized mRNA transcripts that encode OxPhos protein subunits. PMID: 19680543

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Mitochondrion. Nucleus. Note=Predominantly mitochondrial. Some fraction is nuclear. In the nucleus, it is recruited to nuclear receptor target promoters.
  • 組織特異性：
    Ubiquitously expressed, with highest level in heart, liver, skeletal muscle and testis.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 20495

    OMIM: 610211

    KEGG: hsa:81892

    STRING: 9606.ENSP00000450909

    UniGene: Hs.655105



主站蜘蛛池模板： 欧美亚洲人成网站在线观看| 全球av集中精品导航福利| 激情综合色综合久久综合| 亚洲人成人无码www| 图片区小说区另类春色| 中文乱码免费一区二区三区| 欧美成人aaa片一区国产精品| 国内精品美女视频免费直播| 67194熟妇人妻欧美日韩| 亚洲精品黑牛一区二区三区| 中文字幕乱码中文乱码777| av网站免费线看精品| 日本护士xxxxhd少妇| 内射合集对白在线| 菠萝蜜视频在线观看入口| 白丝乳交内射一二三区| 亚洲性av网站| 国产精品久久久久9999高清| 99国产欧美久久久精品蜜芽| 国产美女a做受大片观看| 伊人久久大香线蕉av五月天| 99re久久精品国产| 亚洲中文字幕精品久久| 亚欧洲精品在线视频免费观看| 无码人妻精品丰满熟妇区| 多人伦交性欧美| 日本熟妇浓毛hdsex| 亚洲日韩av无码一区二区三区人 | 国产乱视频在线观看| 中文 在线 日韩 亚洲 欧美| 久久天天躁狠狠躁夜夜96流白浆| 成 人 免费观看网站| 欧美精品中文字幕亚洲专区| 国产福利萌白酱精品一区| 亚洲成a人片在线观看天堂无码| 久久精品人妻一区二区蜜桃| 日韩精品无码一区二区三区视频| 亚洲伊人久久精品酒店| 欧美又大又色又爽aaaa片| 中文在线а√在线天堂中文| 亚洲国产精品自在拍在线播放蜜臀|