在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁(yè)
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human SRA stem-loop-interacting RNA-binding protein, mitochondrial (SLIRP), partial

Recombinant Human SRA stem-loop-interacting RNA-binding protein, mitochondrial (SLIRP), partial

  • 中文名稱：
    人SLIRP重組蛋白
  • 貨號(hào)：
    CSB-YP867111HU
  • 說(shuō)明書：
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    人SLIRP重組蛋白
  • 貨號(hào)：
    CSB-EP867111HU
  • 說(shuō)明書：
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    人SLIRP重組蛋白
  • 貨號(hào)：
    CSB-EP867111HU-B
  • 說(shuō)明書：
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SLIRP重組蛋白
  • 貨號(hào)：
    CSB-BP867111HU
  • 說(shuō)明書：
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SLIRP重組蛋白
  • 貨號(hào)：
    CSB-MP867111HU
  • 說(shuō)明書：
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SLIRP
  • Uniprot No.：
  • 別名：
    SLIRP; C14orf156; DC23; DC50; PD04872; SRA stem-loop-interacting RNA-binding protein; mitochondrial
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Partial
  • 表達(dá)區(qū)域：
    -
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation.
  • 基因功能參考文獻(xiàn)：
    1. Study demonstrated that the LRPPRC-SLIRP complex is a global RNA chaperone that stabilizes RNA structures to expose the required sites for translation, stabilization, and polyadenylation. PMID: 29146908
    2. assessed, by using CRISPR-Cas9-introduced affinity tag and ChIP-Seq analysis, the genome-wide occupancy of SLIRP, and showed that the protein binds preferentially to G-rich DNA sequences that can fold into G4 structures PMID: 28859475
    3. LRPPRC displays a broad and strong RNA binding capacity in vitro in contrast to SLIRP that associates only weakly with RNA. PMID: 27353330
    4. Although SLIRP is not involved in mediating bcl-2 ability to protect from apoptosis and oxidative damage, bcl-2 binds and stabilizes SLIRP protein and regulates mitochondrial mRNA levels. The BH4 domain of bcl-2 has a role in maintaining this binding. PMID: 26866271
    5. The LRPPRC/SLIRP complex suppressed 3' exonucleolytic mRNA degradation mediated by PNPase and SUV3. PMID: 22661577
    6. LRPPRC exists in a high-molecular-weight complex, and it coimmunoprecipitates with SLIRP, a stem-loop RNA-binding protein. PMID: 20200222
    7. Our data demonstrate that SLIRP modulates NR transactivation, suggest it may regulate mitochondrial function, and provide mechanistic insight into interactions between SRA, SLIRP, SRC-1, and NCoR. PMID: 16762838
    8. SLIRP plays an essential role in maintaining mitochondrial-localized mRNA transcripts that encode OxPhos protein subunits. PMID: 19680543

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Mitochondrion. Nucleus. Note=Predominantly mitochondrial. Some fraction is nuclear. In the nucleus, it is recruited to nuclear receptor target promoters.
  • 組織特異性：
    Ubiquitously expressed, with highest level in heart, liver, skeletal muscle and testis.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 20495

    OMIM: 610211

    KEGG: hsa:81892

    STRING: 9606.ENSP00000450909

    UniGene: Hs.655105



主站蜘蛛池模板： 国产亚洲精品综合一区| 成人欧美一区二区三区黑人| 好爽毛片一区二区三区四| 性一交一无一伦一精一品| 在线播放十八禁视频无遮挡| 国产明星裸体xxxx视频| 国产女人18毛片水真多18精品| 欧美精品久久久久久久自慰| 亚洲成年网站青青草原| 亚洲成在人网站无码天堂| 亚洲va韩国va欧美va| 色播久久人人爽人人爽人人片av | 免费人成视频19674不收费| 日本强好片久久久久久aaa | 久久性色av亚洲电影| 亚洲国产精品久久精品| 国产精品videossex久久发布 | 天堂俺去俺来也www色官网| 日本亲子乱子伦xxxx50路| 国产在线精品一区在线观看| 任我撸在线视频| 亚洲国产成人精品无码区在线秒播 | 国产成人免费无码视频在线观看 | 国产成人亚洲精品无码电影| 精品成人毛片一区二区| 好吊色欧美一区二区三区四区| 国产精品96久久久久久| 亚洲一码二码三码精华液| 亚洲一区二区三区中文字幕在线| 亚洲日本韩国| 免费无码a片一区二三区| 免费乱理伦片在线观看八戒| 国产毛片久久久久久国产毛片 | 四虎永久免费地址入口| 偷拍农村老熟妇xxxxx7视频| 亚洲 中文字幕 日韩 无码| 日日噜噜夜夜狠狠久久丁香五月| 国产美女久久精品香蕉| 无码国产精品久久一区免费| 欧美性生交大片免费看| 免费人成网站视频在线观看国内|