在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human SH3 domain-binding protein 1 (SH3BP1)

  • 中文名稱:
  • 貨號:
    CSB-YP2306HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-EP2306HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-EP2306HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-BP2306HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
  • 貨號:
    CSB-MP2306HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    3BP1
  • Uniprot No.:
  • 別名:
    SH3 domain-binding protein 1 SH3BP1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration. Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions. Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment. It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells.
  • 基因功能參考文獻:
    1. Study demonstrated a high SH3BP1 expression in cervical cancer tissues and correlated with a shorter overall survival. Its expression is even higher in cisplatin resistant cervical neoplasm tissues compared to that of the cisplatin-sensitive ones. Furthermore, SH3BP1 plays an important role in the regulation of cervical cancer cell invasion, migration, and chemoresistance through Rac1/Wav2. PMID: 28786507
    2. Splicing of SH3BP1 and CIN gene loci produces the novel brain specific splice variant BGIN. PMID: 23223568
    3. Epithelial junction formation and morphogenesis require a dual activity complex, containing SH3BP1 and CapZ, that is recruited to sites of active membrane remodeling to guide Cdc42 signaling and cytoskeletal dynamics. PMID: 22891260
  • 亞細胞定位:
    Cell projection. Cell junction, tight junction. Cell junction, adherens junction. Cell projection, phagocytic cup. Nucleus. Cytoplasm, cytosol.
  • 數據庫鏈接:

    HGNC: 10824

    OMIM: 617368

    KEGG: hsa:23616

    STRING: 9606.ENSP00000350018

    UniGene: Hs.601143



主站蜘蛛池模板: 久久99精品久久久久久水蜜桃| 亚洲日本乱码一区二区产线一∨| 好紧好湿好黄的视频| 在线视频网站www色| 欧美真人性野外做爰| 97久久婷婷五月综合色d啪蜜芽| 国产av亚洲精品久久久久久小说| 上司人妻互换中文字幕| 大香伊蕉在人线国产免费| 国产午夜成人无码免费看不卡| 国产av国片精品有毛| 天天爽夜夜爽人人爽曰| 97久久精品无码一区二区| 欧美黑人巨大videos精品男男| 丰满的少妇hd高清中文字幕| 亚洲综合另类小说色区一| 乱码午夜-极品国产内射| 狠狠色噜噜狠狠狠888777米奇| 亚洲熟妇无码av不卡在线播放| 美女裸体视频永久免费| 亚洲性色av一区二区三区| 国产成+人+综合+亚洲欧美| 人与性动交aaaabbbb| 欧美深性狂猛ⅹxxx深喉| 精品午夜国产福利观看| 亚洲丰满熟妇在线播放电影全集| 国产亚洲精品一区二区三区| 在线欧美日韩制服国产| 欧美极品色午夜在线视频| 真人无码作爱免费视频| 国产精品亚洲专区无码web| 亚洲日韩欧美国产另类综合| 激情综合丁香五月| 中文字幕人成无码人妻 | 亚洲卡一卡二乱码新区仙踪| 国产免费又爽又色又粗视频| 国产女人与公拘交在线播放| 九九久久精品国产免费看小说| 国产午夜手机精彩视频| 无码人妻精品一区二| 久久www成人片免费看|