在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SH3BP1 Antibody

  • 中文名稱:
    SH3BP1兔多克隆抗體
  • 貨號:
    CSB-PA021223GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    SH3BP1
  • 別名:
    3BP 1 antibody; 3BP-1 antibody; 3BP1_HUMAN antibody; ARHGAP43 antibody; dJ37E16 antibody; FLJ21318 antibody; OTTHUMP00000028981 antibody; SH3 domain binding protein 1 antibody; SH3 domain-binding protein 1 antibody; Sh3bp1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Human SH3BP1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration. Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions. Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment. It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells.
  • 基因功能參考文獻:
    1. Study demonstrated a high SH3BP1 expression in cervical cancer tissues and correlated with a shorter overall survival. Its expression is even higher in cisplatin resistant cervical neoplasm tissues compared to that of the cisplatin-sensitive ones. Furthermore, SH3BP1 plays an important role in the regulation of cervical cancer cell invasion, migration, and chemoresistance through Rac1/Wav2. PMID: 28786507
    2. Splicing of SH3BP1 and CIN gene loci produces the novel brain specific splice variant BGIN. PMID: 23223568
    3. Epithelial junction formation and morphogenesis require a dual activity complex, containing SH3BP1 and CapZ, that is recruited to sites of active membrane remodeling to guide Cdc42 signaling and cytoskeletal dynamics. PMID: 22891260
  • 亞細胞定位:
    Cell projection. Cell junction, tight junction. Cell junction, adherens junction. Cell projection, phagocytic cup. Nucleus. Cytoplasm, cytosol.
  • 數據庫鏈接:

    HGNC: 10824

    OMIM: 617368

    KEGG: hsa:23616

    STRING: 9606.ENSP00000350018

    UniGene: Hs.601143



主站蜘蛛池模板: 十八禁视频在线观看免费无码无遮挡骂过| 精品性高朝久久久久久久| 国产熟妇疯狂4p交在线播放| 欧美日韩人成视频在线播放| 国产精品久久久久久影视不卡| 99国内精品久久久久久久| 国产精品自在线拍国产| 另类亚洲综合区图片小说区| 久久www免费人成_看片中文| 97在线观看永久免费视频| 欧美日韩在线亚洲综合国产人| 免费观看18禁无遮挡真人网站| 国内无遮挡18禁无码网站免费| 精品一区二区三区在线播放视频| 亚洲 欧美 日韩 国产综合 在线| 亚洲乱码国产乱码精品精大量| 熟妇丰满大屁股在线播放| 亚洲熟妇无码av不卡在线播放| 午夜dj在线观看免费视频| 日韩精品无码视频一区二区蜜桃| 免费人成在线视频无码| 两性色午夜视频免费无码| 小sao货水好多真紧h视频| 男人扒开女人双腿猛进视频| 日本黄漫动漫在线观看视频| 国产亚洲精品久久久久丝瓜| 看曰本女人大战黑人视频| 性欧美疯狂xxxxbbbb| 永久免费精品成人网站| 亚洲人成网站在小说| 欧美男生射精高潮视频网站 | 国产国拍精品av在线观看| 国产果冻豆传媒麻婆| 夜夜躁很很躁日日躁麻豆| 国产高清av在线播放| 免费无码作爱视频| 国产久久精品| 国产精品无码专区av在线播放 | 亚洲欧美韩国综合色| 亚洲男人成人性天堂网站| 天堂资源最新在线|