在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Ribonuclease 7 (RNASE7)

Recombinant Human Ribonuclease 7 (RNASE7)

  • 中文名稱：
    人RNASE7重組蛋白
  • 貨號：
    CSB-YP872431HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人RNASE7重組蛋白
  • 貨號：
    CSB-EP872431HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人RNASE7重組蛋白
  • 貨號：
    CSB-BP872431HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    RNASE7
  • Uniprot No.：
  • 別名：
    EC 3.1.27.-; MGC133220; Ribonuclease 7; ribonuclease, RNase A family, 7; RNAS7_HUMAN; RNase 7; RNASE7; SAP 2; SAP-2; Skin derived antimicrobial protein 2; Skin-derived antimicrobial protein 2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    29-156
  • 氨基酸序列
    KP KGMTSSQWFK IQHMQPSPQA CNSAMKNINK HTKRCKDLNT FLHEPFSSVA ATCQTPKIAC KNGDKNCHQS HGAVSLTMCK LTSGKHPNCR YKEKRQNKSY VVACKPPQKK DSQQFHLVPV HLDRVL
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium. Causes loss of bacterial membrane integrity. Probably contributes to urinary tract sterility. Bactericidal activity is independent of RNase activity.
  • 基因功能參考文獻：
    1. These data suggest that the induction of RNase 7 in response to Mycobacterium tuberculosis could have a role in anti-mycobacterial immunity. PMID: 29346642
    2. RNase 7 has immunomodulatory functions on TH2 cells and decreases the production of TH2 cytokines in the skin. PMID: 28378334
    3. Our results indicate that RNase 7 is an important factor released by keratinocytes to control the growth of P. aeruginosa on the skin surface. PMID: 27513608
    4. Insulin and PI3K/AKT signaling are essential for RNase 7 expression and increased infection risks in diabetic patients may be secondary to suppressed RNase 7 production. PMID: 27401534
    5. This article provides an overview about the role of RNase 7 in cutaneous defense with focus on the molecular mechanism of the antimicrobial activity of RNase 7, the regulation of RNase 7 expression, and the role of RNase 7 in skin diseases. [review] PMID: 27089327
    6. RNH1 bound to RNase 7 and suppressed its antimicrobial activity by blocking its ability to bind the cell wall of uropathogenic bacteria. PMID: 24107847
    7. RNase 7 is an antimicrobial protein that plays an important role in the innate immune defense system of human epithelia. PMID: 12244054
    8. Suggest that RNase 7 may function as antimicrobial peptide with a role in the differentiation and development of the primitive epidermis. PMID: 23545750
    9. the influence of STAT3 on the IL-17A/IFN-gamma -mediated RNase 7 induction PMID: 23555696
    10. RNase 7 expression is increased in the urinary tract with infection and has antibacterial activity against uropathogens at micromolar concentrations. PMID: 23302724
    11. a complex relationship between tear induction of miR-762, its modulation of innate defense genes, and P. aeruginosa internalization PMID: 23469087
    12. RNASE7 prevents staphylococcal skin infections PMID: 20668470
    13. proteases contribute indirectly to the defense function of the stratum corneum by releasing the RNase inhibitor mediated inhibition of RNase 5 and RNase 7. PMID: 19262607
    14. Using phospholipid vesicles as membrane models, RNase 3 triggers first the vesicle aggregation, while RNase 7 induces leakage well before the aggregation step. PMID: 19366593
    15. data indicate that RNase 7 contributes to the E. faecium-killing activity of skin extracts and suggest an important role for RNase 7 in the protection of human skin against E. faecium colonization PMID: 19641608
    16. These findings suggest that antimicrobial peptides found at high baseline levels in healthy skin, such as RNase 7, confer protection against Staphylococcus aureus infection of the skin. PMID: 19919305

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Pancreatic ribonuclease family
  • 組織特異性：
    Expressed in collecting ducts in kidney, and in apical uroepithelium in bladder (at protein level). Expressed in various epithelial tissues including skin, respiratory tract, genito-urinary tract and, at a low level, in the gut. Expressed in liver, kidney
  • 數據庫鏈接：

    HGNC: 19278

    OMIM: 612484

    KEGG: hsa:84659

    STRING: 9606.ENSP00000298690

    UniGene: Hs.525206



主站蜘蛛池模板： 十八禁av无码免费网站| 国产在线无码一区二区三区| 国产好吊看视频在线观看| 99c视频色欲在线| 毛片无码国产| 日日鲁鲁鲁夜夜爽爽狠狠| 亚洲欧洲国产码专区在线观看| 亚洲伦无码中文字幕另类 | 中文无码乱人伦中文视频在线| 风流老熟女一区二区三区| 国产成人无码av片在线观看不卡| 久久国产超碰女女av| 天天躁日日躁狠狠躁av中文| 日本熟妇色xxxxx日本免费看| 无码综合天天久久综合网| 中文字幕一区二区三区久久网站| 夜夜躁很很躁日日躁麻豆| 蜜臀av午夜一区二区三区| 在线观看成人年视频免费 | 中文字幕在线亚洲精品| 中文字幕日产熟女乱码| 日韩午夜理论片 中文字幕| 性少妇中国内射xxxx狠干| 国产真实乱对白精彩| 亚洲综合无码无在线观看| 欧美国产日本高清不卡| 国产成人久久精品流白浆| 久久久久国产精品人妻aⅴ院| 国产一卡2卡3卡4卡精品| 亚洲丁香五月天缴情综合| 欧美私人情侣网站| 午夜伦4480yy私人影院久久| 日本大香伊一区二区三区| 国产福利一区二区三区在线观看 | 精品视频一区二区三三区四区| 秋霞国产精品一区二区| 国产精品久久久久久久久久红粉| 人人妻人人做人人爽| 国产亚洲日韩在线aaaa| 久久亚洲熟女cc98cm| 人人做人人爽人人爱|